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Sr Bernice Research Programme in Inherited Heart Diseases
Molecular Cardiology Unit,Victor Chang Cardiac Research Institute
Level 6, 384 Victoria St, Darlinghurst NSW 2010
Tel: (02) 9295 8518 Fax: (02) 9295 8501
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Molecular Mechanisms of Inherited Heart Diseases
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Project 1: Molecular genetics studies of familial atrial fibrillation
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| Introduction: Atrial Fibrillation (AF) is the most common cardiac arrhythmia and is a major risk factor for illness and death in our community. Recently, the importance of inherited gene defects in the pathogenesis of AF has been recognised. The genes involved, and the mechanisms whereby mutations in these genes cause abnormal atrial electrical activation, are poorly understood. We are studying families with AF to identify disease-causing genes. We hope that a detailed understanding of the molecular defects that cause AF will facilitate new approaches to the diagnosis and treatment of this disorder. |
| Research Topic: Gene Discovery Studies in Familial AF. This project involves mutation screening of candidate genes in DNA isolated from individuals in families with a suspected inherited cause of AF. A number of laboratory techniques will be utilised, including: determination of genomic structure of candidate genes, primer design, PCR amplification of genomic DNA, gel elctrophoresis, restriction enzyme digestion, DNA sequence analysis. In addition, interested students will have the opportunity to gain experience in bioinformatics approaches to candidate gene selection. |
| Available for 1 student |
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Selected References (Available on request)
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