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Honours Team Leaders
| Associate Professor Alison Todd |
atodd@medau.jnj.com
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| Molecular Diagnosis of Disease |
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Molecular Diagnostics is forecast to be the highest area of growth in the in vitro diagnostics field over the next five years. The explosion of information provided by the genomics era has produced a better understanding of many diseases. Molecular technology is constantly evolving as a consequence of the desire for methodology which can deliver more data within a shorter time frame.
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| Program 1: Applications of MNAzymes in medicine. |
| Availability for 1 student |
| There are many tools with which scientists can build new analytical systems. In addition to protein enzymes which are widely used, there are also a number of enzymes which are comprised of either DNA (DNAzymes) or RNA (ribozymes). Our laboratory exploits these molecules in a number of unique ways and we have recently invented a new class of nucleic enzyme known as multi-component nucleic acid enzymes (MNAzymes). These versatile molecules can be incorporated into a broad range of protocols useful for preclinical drug discovery and/or in clinical diagnostics. The opportunity exists for a PhD student to study with the Nucleic Acid Analytical Technology Group at Johnson & Johnson Research Pty Ltd on a project which involves the use of MNAzymes for medical applications. Students with an interest in nanotechnology or bioengineering are encouraged to apply. |
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| Selected References (Available on request) |
- Elisa Mokany, Tram Doan, Paul Young, Ronald Suwandi, Mehnazz Lomas, Li Wang and Alison Todd. “A new real-time PCR technology, which is mediated by Multi-component Nucleic Acid enzymes (MNAzymes), has a superior capacity for multiplex analysis“. Abstract for the CHI Conference “Quantitative PCR, Microarrays & Biological Validation” , Providence, Rhode Island, USA, Oct 2007
- Elisa Mokany, Don Birkett, Alison Todd, Tram Doan. “Multi-component Nucleic Acid Enzymes and Methods for their use”. PCT/AU/2006/001473; WO 2007/041774A1
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