Dr. Gillian Scott
- Position: Vice-Chancellor's Postdoctoral Fellow
- Room: Research Level 3, Clinical Sciences Building, Prince of Wales Hospital
- Phone: (+61 2) +612 9382 9096
- Fax: (+61 2) 9382 8533
- email: g.scott@unsw.edu.au
Professional experience
- 2009–present: Vice Chancellor’s Postdoctoral Fellow, School of Biotechnology and Biomolecular Sciences
- 2004–2008: Postdoctoral Scientist, Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital
- 2005–2008: Adjunct Research Associate, School of School of Biotechnology and Biomolecular Sciences
Research contribution
I have been involved in human cytomegalovirus (CMV) research for more than 10 years, primarily investigating pathogenesis of infection in at-groups such as immunocompromised transplant recipients and neonates infected in utero. My most significant research contributions have included the identification of novel mutations that confer antiviral resistance to human CMV isolates causing disease, establishment of the murine CMV animal model for analysis of antiviral susceptibility and resistance and characterisation of the CMV DNA polymerase and protein kinase homologues important for viral replication.
I am now also focused on understanding the pathogenic consequences of CMV placental infection and transmission, including the molecular and cellular changes induced by CMV replication and contribution to adverse fetal outcomes. This work is being carried out in collaboration with Professor William Rawlinson in the Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital. International collaborators include Prof Manfred Marschall, University of Erlangen-Nuremberg, Germany; Prof Sunwen Chou, Oregon Health and Science University, USA; and Prof Geoffrey Shellam, University of Western Australia. This work has attracted over $500,000 in competitive funding since 2004.
Memberships
- 2008 – present Co-convenor of the ASM NSW-ACT Branch Virology Special Interest Group
- 2005 – present Member of the Australian Society for Microbiology (MASM)
Invited seminars
- May 2007 School of Pathology, University of Cambridge, UK
- May 2007 Institute of Clinical and Molecular Virology, Germany
- Aug 2007 Johnson and Johnson Research, Sydney
Awards
- 2008 Australian Society for Microbiology NSW-ACT Branch Service Award
- 2007 Roche Travel Award
- 2006 Australian Herpes Management Forum Travel Award
Publications
- Rechter, S., Scott, G.M., Eickhoff, J., Zielke, K., Auerochs, S., Müller, R., Stamminger, T., Rawlinson, W.D. and Marschall, M. (2009)
- Cyclin-dependent kinases phosphorylate the cytomegalovirus RNA export protein pUL69 and modulate its nuclear localization and activity
- Journal of Biological Chemistry, in press, accepted 29th Jan, 2009, doi: 10.1074/jbc.M805693200. Available online at http://www.jbc.org/cgi/content/abstract/M805693200v1
- Johal, H., Scott, G.M., Jones, R., Camaris, C., Riordan, S., Rawlinson, W.D. (2009)
- Mouse Mammary Tumour Virus - Like Virus (MMTV-LV) is present within the liver in a wide range of hepatic disorders and unrelated to nuclear p53 expression or hepatocarcinogenesis.
- Journal of Hepatology 50: 548-554
- Iwasenko, J.M., Scott, G.M., Rawlinson, W.D., Keogh, A., Mitchell, D. and Chou, S. (2009)
- Successful valganciclovir treatment of post-transplant cytomegalovirus infection in the presence of UL97 mutation N597D.
- Journal of Medical Virology. 81:507-510
- Woon, H.G., Scott, G.M., Yiu, K-L., Miles, D.H. & Rawlinson, W.D. (2008)
- Identification of putative functional motifs in viral proteins essential for human cytomegalovirus DNA replication.
- Virus Genes 37:193-202.
- Scleiss, M., Eickhoff, J., Auerochs, S., Leis, M, Abele, S., Rechter, S., Choi, Y., Anderson, J., Scott, G., Rawlinson, W., Michel, D., Ensminger, S., Klebl, B., Stamminger, T., Marschall, M. (2008)
- Protein kinase inhibitors of the quinazalone class exert anti-cytomegaloviral activity in vitro and in vivo
- Antiviral Research 79(1):49-61
- Bradley, A.J., Kovacs, I.J., Gatherer, D., Dargan, D.J., Alkharsah, K.R., Chan, P.K.S., Carman, W.F., Dedicoat, M., Emery, V.C., Geddes, C.C., Gerna, G., Ben-Ismaeil, B., Kaye, S., McGregor, A., Moss, P.A., Pusztai, R., Rawlinson, W.D., Scott, G.M., Wilkinson, G.W.G., Schulz, T.F., Davison, A.J. (2008)
- Genotypic analysis of two hypervariable human cytomegalovirus genes.
- Journal of Medical Virology. 80 (9): 1615-1623
- Beld, M.G.H.M., Birch, C., Cane, P.A., Carman, W., Claas, E.C.J., Clewley, J.P., Domingo, E., Druce, J., Escarmis, C., Fouchier, R.A.M., Foulongne, V., Ison, M.G., Jennings, L.C., Kaltenboeck, B., Kay, I.D., Kubista, M., Landt, O., Mackay, I.M., Mackay, J., Niesters, H.G.M., Nissen, M.D., Palladino, S., Papadopoulos, N.G., Petrich, A., Pfaffl, M.W., Rawlinson, W., Reischl, U., Saunders, N.A., Savolainen-Kopra, C., Schildgen, O., Scott, G.M., Segondy, M., Seibl, R., Sloots, T.P., Tang, Y-W., Tellier, R. and Woo, P.C.Y. (2007)
- Experts’ Roundtable: Real-time PCR and Microbiology
- in Real-time PCR in Microbiology from diagnosis to characterization, I.M. Mackay, Chapter 10; page 357
- Scott, G.M., Weinberg, A., Rawlinson, W.D. and Chou, S. (2007)
- Multi-Drug Resistance Conferred by Novel DNA Polymerase Mutations in Human Cytomegalovirus Isolates.
- Antimicrobial Agents and Chemotherapy. 51(1): 89-94
- Iwasenko, J.M., Scott, G.M., Ziegler, J.B. and Rawlinson, W.D. (2007)
- Emergence and persistence of multiple antiviral-resistant CMV strains in a highly immunocompromised child
- Journal of Clinical Virology. 40(2):152-155