The School of Biotechnology and Biomolecular Sciences at UNSW

The University of New South Wales

A leading research and teaching school with expertise in biotechnology, molecular biology, genetics, environmental microbiology, medical microbiology, immunology, biochemistry, protein chemistry and other areas of biological science.

Image of Dr. Dallia Catzel

Dr. Dallia Catzel

  • Position: Associate Lecturer
  • Room: 109, Biological Sciences
  • Phone: (+61 2) 9385 3899
  • Fax: (+61 2) 9385 1483
  • email: d.catzel@unsw.edu.au

Professional Experience

  • Contract positions at UNSW (Bioengineering Centre)

Research Contribution

I have extensive knowledge and expertise in large-scale preparative electrophoresis. During the last 7 years I have been involved in buffer design for use of the instrument and purification of recombinant biopharmaceuticals including monoclonal antibodies, recombinant human growth hormone, FSH, EPO, TSH and others.

I am currently undertaking research which involves the separation of glycoform variants. The advantage of this technology could be applied to generation of more potent biopharmaceutical product by increasing in vivo potency through isoform profile selection of recombinant glycoprotein biopharmaceuticals. Further work is being carried out on the production and purification of cytokines and growth factors vital in stem cell propagation. Different isoform fractions of these preparations will be applied to different types of stem cells (collaboration with Assoc. Prof Kuldip Sidhu, Stem Cell Laboratory, Medicine).

I have a collaborative project with Dr Nicodemus Tedla and Dr Katherine Bryant (Medicine). This research involved the expression and functions of leukocyte Immunoglobulin-like Receptor (LIR-4) in inflammatory arthritis. I am also a key member of the NCRIS funded UNSW recombinant products facility.

Honours & Awards

  • Australian Postgraduate Award (APA) scholarship, Industry Top-Up Scholarship Award
  • Biochemical Engineering (XIII) 2003, Colorado, USA Student Registration Award
  • Poster Presentation Award: Pacific Rim Conference (New Zealand 2002)

Publications

Catzel D, Chin DY, Stanton PG, Gray PP, Mahler SA (2006)
Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology
Journal of Biotechnology;122:73-85
Catzel, D., Lalevski, H., van Dyk, D., Gray, P., Marquis C.P. and Mahler, S.M. (2003)
Purification of human growth hormone using Gradiflow technology.
Protein Expression and Purification. 32: 126-134