Understanding the mechanism by which IFNa treatment leads to removal of the HCV virus from an infected cell is of interest to Associate Professor Peter White.
Investigation of the Effect of Specific H. pylori Virulence Factors In-Vitro
The bacterium Helicobacter pylori is a significant stomach pathogen of humans and has been causally linked to the development of gastritis, peptic ulcer disease (PUD) and gastric cancer (GC). Although 50% of the world’s population is infected with H. pylori, only a small percentage develops PUD and GC. The variable response to infection has led to a search for cofactors that modulate the risk of disease outcomes in infected individuals.
The aim of this project is to investigate, in vitro, the effect of specific H. pylori virulence factors on inflammation and cellular changes in gastric tissue. Specifically, H. pylori isolates possessing different combinations of virulence factors will be investigated in vitro using gastric cell lines. These studies aim to clarify the respective roles and importance of H. pylori virulence factors in H. pylori related disease. The project will include the use of cultural, molecular and immunological techniques.
BABS personnel that are responsible for this project