Spoligotype patterns evolve through the deletion of spacer sequences that cannot be recovered and have provided Dr Mark Tanaka with a rich source of data with which to understand the transmission of disease.
Cholesterol and Cancer
Cells need cholesterol to grow and proliferate, while cancer is a consequence of unrestrained cell growth and proliferation. We have exciting new data to indicate that there may be a fundamental link between cholesterol and cancer [Du et al. Molecular Biology of the Cell 2006 Jun;17(6):2735-45].
In this project, we use molecular cell biological techniques to further explore this link in the setting of prostate cancer. Methods will include mammalian cell culture, fluorescence microscopy, real-time PCR gene transfection, use of luciferase reporter assays, SDS-PAGE and Western blotting.
BABS personnel that are responsible for this project