Associate Professor Peter White combines techniques in molecular biology and bioinformatics to describe the evolution of Norovirus outbreak strains.
Engineering of a Protein Scaffold for Functional Drug Delivery Applications
Primary Supervisory: Edwin Huang PhD, Chris Marquis PhD
Subject area and Aims: Modification of a human protein to permit functional drug delivery
Background: Our laboratory has worked for some years on an immunomodulatory protein that is currently in clinical trials. We aim to investigate the potential of using this protein to deliver drugs via unique sequence modifications. Preliminary studies will focus on a “proof-of-concept” approach, in order to determine the feasibility of engineering a key site in the protein and its impact on the production, purification and stability of the modified protein
Significance and current work: Small molecule or peptide drug delivery via biocompatible protein scaffolds is an emerging field. Functionalisation of proteins is possible to direct drug targets. Further, circulating half-life of some drug entities may be improved by binding to natural proteins.
BABS personnel that are responsible for this project