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Research> MCB

Molecular Cell Biology

Research in Molecular and Cell Biology is primarily concerned with understanding biological and cellular processes in molecular terms. It covers the disciplines of Molecular Biology, Molecular Genetics, Molecular Cellular Biology, Biochemistry, Cancer Biology, Immunology, Parasitology and Comparative Genomics.

There are strong research groupings investigating Yeast Biology and Oxidative Stress as well as DNA-drug interactions, mammalian cholesterol homeostasis, anti-malarial drug development, and ageing and disease

Facilities and Affiliations:
Ramaciotti Centre for Gene Function Analysis

Research Teams:

Team Leader
Research Areas
Prof Bill Ballard
  • Mitochondrial metabolism, aging and disease
  • Visit Ballard Lab
Dr Andrew Brown
  • Molecular and biochemical elucidation of cholesterol homeostasis
  • Oxysterols and naturally occurring agonists of nuclear receptors involved in cardiovascular disease prevention
Dr Margaret Cooley
  • The interaction of pathogens with the adaptive immune response
  • Exploration of immunomodulation by microbial natural products
Prof Ian Dawes
  • Integration and modelling of cellular gene regulation
  • Molecular defenses against oxidative stress in yeast
  • Function and regulation of genes involved in one-carbon metabolism
  • Regulation and structure of spliceosomal proteins
  • Gene function analysis: use of robotics and DNA microarrays for high throughput functional genomics
  • Metabolomics
  • Microbial strain and process development for the fermentation industry
  • Visit Dawes lab homepage
Dr Louise Lutze-Mann
  • Analysis of genetic changes induced by ionising radiation in transgenic mice
  • The use of microarrays in the analysis of cellular responses to DNA damage
  • Novel anti-cancer therapeutics based on targeted delivery of radioactive compounds (In collaboration with Allen)
  • The use of novel L-nucleoside prodrugs as anti-cancer agents (In collaboration with A/Prof Vincent Murray and A/Prof Annette Gero)
Dr Paul March
  • The role of GTPases in regulating ribosomes, membrane function, cell division and chromosome segregation
  • Novel bacteriophage and bacteriophage polymerases
  • Protein expression, protein structure, and protein purification
Dr Ian McFarlane
  • Production of chemicals from plant cell cultures
  • Biosynthesis of nitro compounds in plants and fungi: identifying genes through genomics and proteomics
  • Regulation of gene expression of ammonia assimilation in legumes
  • Forensic botany: identifying plants using DNA fingerprinting
A/Prof Vincent Murray
  • Development of more effective anti-cancer drugs based on cisplatin
  • The interaction of cisplatin with telomeres
  • Development of a gene therapy strategy to specifically kill cervical tumour cells infected with Human Papilloma Virus

 

Dr Kathy Takayama
  • RNA regulation of gene expression
  • Molecular biology of bacterial stress adaptation
  • Visualisations in science education
  • Collaborative online communities in science education
Dr Noel Whitaker
  • Elucidation of the role of high risk Human Papillomavirus (HPV) E6 transformation protein in the degradation of p53 and in the immortalisation/transformation of human keratinocytes
  • Identification of viruses which maybe involved in hormonally responsive cancer (including breast and prostate)
  • Identification of HPV types in a Hoi Chin Minh City normal and cancer population