New Factors in Achieving Cholesterol Balance in Cells

An imbalance of cholesterol plays a role in several diseases. Therefore, knowing precisely how cells regulate their cholesterol levels is central to understanding the development of these diseases, and to identify possible new treatments. The statin class of drugs, worth >$30 billion a year, have been effective in treating heart disease, but are not without their side effects. Statins inhibit a very early step in cholesterol synthesis, and little attention has been paid to later steps in the pathway. This project investigates the regulation of novel control points later in cholesterol synthesis, which have been largely overlooked.

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