Ageing and age-related degenerative processes are characterised by a broad range of markers, including increased accumulation of damaged cellular macromolecules.  To date there have been many theories regarding the factors that influence longevity. Two models that have been proposed include the free-radical theory of ageing and the caloric consumption theory of ageing.  Studies of the model eukaryotic organism Saccharomyces cerevisiae provide important insight into the cellular processes that influence longevity and highlight the complex nature of the ageing process.

This project will examine exciting and novel ideas regarding the way caloric availability/consumption influences damage to cellular components, and try to identify the source and nature of the relevant cell damage.

Selected References (available on request)

• Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science (2003) 299, 1751–1753.
• Yeast life-span extension by calorie restriction is independent of NAD fluctuation.  Science (2003) 302, 2124-2126.

BABS personnel responsible for this project:

• Ian Dawes