Professor Hazel Mitchell
- 2007-current: Professor
- 1999-2002 Senior Lecturer; 2002-2006:Associate Professor, School of BABS
- 1996-1998 Adjunct Senior Lecturer and Senior Research Associate, School of BABS
- 1993-1996 NHMRC Research Associate, School of BABS
Professor Mitchell was one of the first in the world to study the epidemiology of H. pylori infection and developed one of the first ELISA assays for the diagnosis of H. pylori infection. Using this she demonstrated that transmission was person to person and showed that infection was mostly contracted in childhood. In 1996 she was a founding organiser of the Western Pacific Helicobacter pylori study group and was convenor of the first meeting in Guangzhou, China and international scientific adviser for subsequent meetings in Malaysia, Indonesia, Australia, Japan and Thailand.
Over the last 17 years she has undertaken major studies in China in the area of epidemiology, pathogenesis and gastric cancer. In 1998 she was invited by Professor I Segal to collaborate on an investigation of H. pylori infection in South Africa. This collaboration led to the award of the South African Gastroenterology Society Astra Fellowship to further develop this research collaboration on the role H. pylori virulence determinants, the immune response and host genetic factors in the causation of H. pylori related disease. In 2003, she initiated a major study, in collaboration with Professor David Forman and the Victorian Cancer Council, to investigate the role of I and host genetic polymorphisms in gastric cancer in Australian subjects, the results of which have recently been submitted for publication. In 2004 she was awarded a 3-year grant by the NSW Cancer Council to conduct a study with collaborators in Malaysia, Singapore, Australia and the UK into the role of bacterial, host genetic and dietary factors in gastric cancer. In addition to these collaborations, Professor Mitchell has an ongoing collaboration on I with Professor Lars Engstrand, Karolinska Institute, Sweden where she undertook a 6-month sabbatical in 2006.
In addition to studies in humans, she has been involved in an increasing number of studies in animal models of disease in the areas of H. pylori pathogenesis, and investigation of the action of probiotics and IBD. In 2001 she was awarded an Eli and Edythe Broad Foundation grant to conduct preliminary studies into the role of therapeutic vaccination with Helicobacter species in a mouse model of IBD and in 2006 a second Broad Foundation grant to investigate the role of mucus associated bacteria in Crohn's disease in children. The findings of this latter grant led to the award of a 3-year NHMRC grant (2008-2010) to continue this work.
Honours & Awards
- 2000 South African Society for Gastroenterology Astra Fellowship
- Committee member of NSW Branch of the Australian Society for Microbiology
- ASM representative on the Joint ASM/AIMS/AACB conference committee.
- Member of the RCPA Serology QAP Scientific Advisory Network
- Member of the Cancer Council of NSW Colorectal STREP Stage 2 Steering Commit
- Member of the NHMRC Microbiology Grant Review Panel
- Initiator, scientific program developer, and organiser of "The First Western Pacific Helicobacter Congress", China and scientific advisor to following 5 congresses
- Conference organiser: 13th International Workshop on Campylobacter, Helicobacter and Related Organisms, Australia and International Workshop on Gastric Cancer, China
- Member European study group on Pathogenesis and Immunology in Helicobacter infections
- Member of the Editorial Board of the Journal Helicobacter
- Member of the European Paediatric Helicobacter Task Force
- Grant Reviewer - National: NHMRC; International: New Zealand Medical Research Council, The Singapore Medical Research Council, Broad Foundation of America
Active Research Projects
Hallab, J.C., Leach, S.T., Zhang, L., Mitchell, H.M., Oei, J., Lui, K & Day, A.S.(2013)
Molecular characterization of bacterial colonization in the preterm and term infant's intestine.
Indian Journal of Pediatrics. 80: 1-5.
Gunaletchumy, S.P., Teh, X. , Khosravi, Y., Chua, E.G. , Kavitha, T., Ramli, N.S., Mason, J.N., Lee, H.T., Alias, H., Zaidan, N.Z., Tay, L.C., Rudd, S., Mitchell, H.M., Kaakoush, N.O., Loke, M.f., Goph, K.L. & Vadivelu, J. (2012)
Draft genome sequences of Helicobacter pylori isolated from Malaysia, cultured from patients with functional dyspepsia and gastric cancer.
Journal of Bacteriology. 194(20): 5695-5696.
Lavrencic, P., Kaakoush, N.O., Huinao, K.D., Kain, N. & Mitchell, H.M. (2012)
Investigation of motility and biofilm formation by intestinal Campylobacter concisus strains.
Gut Pathogens. 4(1): 22.
Castano-Rodriguez, N., Kaakoush, N.O., Goh, K., Fock, K.M., Chionh, Y.T., Sutton, P., & Mitchell, H.M. (2012)
PAR-1 polymorphisms and risk of Helicobacter pylori-related gastric cancer in a Chinee population.
Anti-Cancer Research. 32(9): 3715-3721.
Kaakoush, N.O., Day, S., Huinao, K.D., Leach, S.T., Lemberg, D.A., Dowd, S.E., & Mitchell, H.M. (2012)
Microbial dysbiosis in pediatric patients with Crohn's disease.
Journal of Clinical Microbiology. 50(10): 3258-3266.
Sirianni, A., Kaakoush, N.O., Raftery, M.J., & Mitchell, H.M. (2012)
The pathogenic potential of Helicobacter pullorum - Possible role for the Type VI secretion system.
Helicobacter. DOI: 10.1111/hel.12009.
Kaakoush, N.O. & Mitchell, H.M. (2012)
Campylobacter concisus - a new player in intestinal disease.
Frontiers in Cellular and Infection Microbiology. 2: 1-5.
Burgos-Portugal, J, Kaakoush, NO, Raftery, MJ, & Mitchell, HM (2012)
Pathogenic potential of Campylobacter ureolyticus.
Infection and Immunity. 80(2): 883-890.
Kaakoush, N.O., Deshpande, N., Wilkins, M.R., Raftery, M.J., Janitz, K. & Mitchell, H. (2011)
Comparative analyses of Campylobacter concisusstrains reveal the genome of the reference strain BAA-1457 is not representative of the species.
Gut Pathogens. 3: 15.
Deshpande, N.P., Kaakoush, N.O., Mitchell, H.M., Janitz, K. , Raftery, M.J., Li, S.S. & Wilkins, M.R. (2011)
Sequencing and validation of the genome of a Campylobacter concisus reveals intra-species diversity.
PLoS ONE. 6(7): e22170.
Keenan, J., Mitchell, H.M., & Day, A.S. (2011)
Interactions between gastric and enteric infections: Clues to the pathogenesis of inflammatory bowel diseases?
New Zealand Medical Journal. 210: 62-067.
Kovach, Z., Kaakoush, N.O., Lamb, S., Zhang, L., Raftery, M.J. & Mitchell, H. (2011)
Immunoreactive proteins of Campylobacter concisus, an emergent intestinal pathogen.
FEMS Immunology and Medical Microbiology. 63(3): 387-396.
Kaakoush, N.O., Deshpande, N.P., Wilkins, M.R., Tan, C., Burgos-Portugal, J.A., Raftery, M.J., Day, A.S., Lemberg, D.A. & Mitchell, H. (2011)
The pathogenic potential of campylobacter concisus strains associated with chronic intestinal diseases.
PLoS One. 6(12): e29045.
Timms, V.J., Gehringer, M.M., Mitchell, H.M., Daskalopoulos, G. & Neilan, B.A. (2011)
How accurately can we detect Mycobacterium avium subsp. paratuberculosis infection?
Journal of Microbiological Methods. 85(1): 1-8.
Mahendran, V., Riordan, S.M., Grimm, M.C., Tran, TAT, Major, J. , Kaakoush, N.O., Mitchell, H. & Zhang, L. (2011)
Prevalence of Campylobacter species in adult Crohn's disease and the preferential colonization sites of Campylobacter species in the human intestine.
PLoS ONE. 6(9): pp. 1-7.
Schmidt, H.M.A., Ha, M.D., Taylor, E.F., Kovach, Z., Goh, K.L., Fock, K.M., Barrett, J.H., Forman, D. & Mitchell, H. (2011)
Variation in human genetic polymorphisms, their association with H pylori acquisition and gastric cancer in a multi-ethnic country
Journal of Gastroenterology and Hepatology. 26(12): 1725-1732.
Zhang S., Zhong, B., Chao, K., Xiao, Y., Cui, Y., Gao, X., Chen, B., He,Y., Hu, P., Chen, M. & Mitchell, H.M. (2011)
The role of Helicobacter species in Chinese patients with inflammatory bowel disease.
Journal of Clinical Microbiology. 49(5): 1987-1989.
Every, A.L., Selwood, L., Castano-Rodriguez, N., Lu, W., Windsor, H.M., Wee, J.L.K., Swierczak, A., Marshall, B.J., Kaakoush, N.O., Mitchell, H.M. & Sutton, P. (2011)
Did transmission of Helicobacter pylori from humans cause a disease outbreak in a colony of Stripe-faced Dunnarts (Sminthopsis macroura)?
Veterinary Research. (Accepted 7 December 2010).
Man, S.M., Kaakoush, N.O. & Mitchell, H.M. (2011)
The role of bacteria & pattern-recognition receptors in the pathogenesis of Crohn’s disease.
Nature Reviews Gastroenterology & Hepatology. (Accepted 2 January 2011).
Coldham, T., Rose, K., O`Rourke, J.L., Neilan, B.A., Dalton, H., Lee, A. & Mitchell, H. (2011)
The detection, isolation and characterisation of Helicobacter species from the gastrointestinal tract of brushtail possum.
Applied and Environmental Microbiology. 77: 1581-1587
Schmidt, H.M., Andres, S., Nilsson, C., Kovach, Z., Kaakoush, N.O., Engstrand, L., Goh, K.-L. Fock, K.M., Forman D. & Mitchell, H.M. (2010)
The cag PAI is intact & functional but HP0521 varies significantly in Helicobacter pylori isolates from Malaysia & Singapore.
European Journal of Clinical Microbiology & Infectious Diseases. 29: 439-451.
Kaakoush, N.O., Man, S.M., Lamb, S., Raftery, M.J., Wilkins, M.R., Kovach, Z. & Mitchell H.M. (2010)
The secretome of Campylobacter concisus.
The FEBS Journal. 1606-1617.
Man, S.M., Kaakoush, N.O., Octavia S. & Mitchell, H.M. (2010)
The internal transcribed spacer region: A new tool in species differentiation & delineation of systematic relationships within the Campylobacter genus.
Applied & Environmental Microbiology. 76: 3071-3081.
Man, S.M., Kaakoush, N.O., Leach, S.T., Nahidi, L., Lu, H.K., Norman, J., Day, A.S., Zhang, L. & Mitchell, H.M. (2010)
Host Attachment, Invasion & Stimulation of Pro-inflammatory Cytokines by Campylobacter concisus & other non-jejuni Campylobacter species: Possible Pathogenic Mechanisms in Crohn’s disease.
Journal of Infectious Diseases. 202: 1855-1865. *Electron microscopy figure featured in cover art in Volume 202, Issue 12.
Kaakoush, N.O., Holmes, J. Octavia, S., Man, S.M., Zhang, L., Castaño-Rodríguez, N., Day, A.S., Leach, S.T., Lemberg, D.A., Dutt, S., Stormon, M., O’Loughlin, E.V. Magoffin A. & Mitchell, H.M. (2010)
Detection of Helicobacteraceae in intestinal biopsies of children with Crohn's disease.
Helicobacter. 15: 549-557.
Mitchell, H.M., Kaakoush, N.O. & Sutton, P. (2010)
Extragastric manifestations of Helicobacter pylori infection.
in Helicobacter pylori in the 21st Century, Sutton P. & Mitchell H.M. (eds) Chapter 5. CABI, UK.
Andres, S., Schmidt, H.A., Mitchell, H.M., Rhen, M., Maeurer, M. & Engstrand, L. (2010)
Helicobacter pylori defines local immune response through interaction with dendritic cells.
FEMS Immunology and Medical Microbiology. 61(2): 168-178
Goldman, C.G, & Mitchell, H.M. (2010)
Helicobacter spp. other than Helicobacter pylori.
Helicobacter. 15(Supp 1): 69-75.
Grehan, M.J., Borody, T.J., Leis, S., Campbell, J., Mitchell, H. & Wettstein, A. (2010)
Durable alteration of the colonic microbiota by the administration of donor fecal flora.
Journal of Clinical Gastroenterology. 44: 551-561.
Man, S.M, Zhang, L., Day, A.S., Leach, S.T., Lemberg, D.A. & Mitchell, H. (2010)
Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohns disease.
Inflammatory Bowel Diseases. 16: 1008-1016.
Wee, J.L.K., Chionh, Y, Ng, G.Z., Harbour, S.N., Allison, C., Pagel, C.M., Mackie, E.J., Mitchell, H.M., Ferrero, R.L. & Sutton, P. (2010)
Protease-Activated Receptor-1 Down-regulates the Murine Inflammatory and Humoral Response to Helicobacter pylori.
Gastroenterology. 138(2): 573-582.
Zhang, L., Budman, V., Day, A.S., Mitchell, H.M., Lemberg, D.A., Riordan, S.M., Grimm, M., Leach, S.T. & Ismail, Y. (2010)
Isolation and detection of Campylobacter concisus fromsaliva of healthy individuals and patients with inflammatory bowel disease.
Journal of Clinical Microbiology. 48: 2965-2967.
Tay, C.Y., Mitchell, H., Dong, Q., Goh, K.-L., Dawes, I.W. & Lan, R. (2009)
Population structure of helicobacter pylori among ethnic groups in Malaysia: Recent acquisition of the bacterium by Malay population.
BMC Microbiology 9: 126.
Zhang, L., Man, S.M., Day, A.S., Leach, S.T., Lemberg, D.A., Dutt, S., Stormon, M., Otley, A., O'Loughlin, T., Magoffin, A., Ng, P.H.Y. & Mitchell, H. (2009)
Detection and isolation of non-jejuni Campylobacter species from children with Crohn's disease.
Journal of Clinicial Microbiology. 121(1): 54-60.
Zhang, L., Man, S., Day, A.S., Leach, S.T., Lemberg, D.A., Dutt, S., Stormon, M., Otley, A., O’Loughlin, E.V., Magoffin, A., Ng, P.H. & Mitchell, H. (2009)
Detection and isolation of Campylobacter species other than C. jejuni from children with Crohn`s disease.
Journal of Clinical Microbiology. 47: 453-455.
Schmidt, H.-M.A. Andres, S., Kaakoush, N.O., Engstrand, L., Eriksson, L., Goh, K.-L. Fock, K.M., Hilmi, I, Dhamodaran, S., Forman D. & Mitchell H.M. (2009)
The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: A case-control study.
Gut Pathogens. 1: 5.
Chionh, Y., Walduck, A., Mitchell, H.M., & Sutton, P. (2009)
A comparison of glycan expression and adhesion of mouse-adapted strains and clinical isolates of Helicobacter pylori.
FEMS Immunology and Medical Microbiology. 57: 25-31.
Fukuda, Y., Shimoyama, T., Ohmura, T., Sano, Y., Nakabayashi, N. Takahashi, R., Fujioka, T., Mitchell, H.M. & Shimoyama, T. (2009)
Characterization and application of a new monoclonal antibody with high specificity for Helicobacter hepaticus.
Helicobacter. 14: 66-71.
Schmidt, H.A., Goh, K., Fock, K., Hilma, I., Dhamodaran, S., Forman, D. & Mitchell, H. (2009)
Distinct cagA EPIYA motifs are associated with ethnic diversity in Malaysia and Singapore.
Helicobacter. 14: 256-263.
Zhang, L., Man, S., Day, A.S., Leach, S.T., Lemberg, D.A., Dutt, S., Stormon, M.O., Otley, A.R., O'Loughlin, E., Magoffin, A., Ng, P. & Mitchell, H.M. (2009)
Campylobacter concisus: a New Character in the Crohn`s Disease Story? Reply.
Journal of Clinical Microbiology. 47: 1614-1615.
Zhang, L., Su, P., Henriksson, A., O’Rourke, J,. & Mitchell H. (2008)
Investigation of the immunomodulatory effects of Lactobacillus casei and Bifidobacterium lactis on Helicobacter pylori infection.
Helicobacter. 13(3): 183-190.
Man, S., Zhang, L., Day, A., Leach, S. & Mitchell H. (2008)
Detection of enterohepatic and gastric Helicobacter species in fecal specimens of children with Crohn’s disease.
Helicobacter. 13(4): 234-238.
Fock, K.M., Talley, N., Moayyedi, P., Hunt, R., Azuma, T., Sugano, K., Xiao, S.D., Lam, S.K., Goh, K.L., Chiba, T., Uemura, N., Kim, J.G., Kim, N., Ang, T.L., Mahachai, V., Mitchell, H., Rani, A.A., Liou, J.M., Vilaichone, R.K. and Sollano, J. (2008)
Asia-Pacific consensus guidelines on gastric cancer prevention.
Journal of Gastroenterology and Hepatology. 23: 351-365.
Leach, S.T., Mitchell, H.M., Geczy, C.L., Sherman, P.M. & Day, A.S. (2008)
S100 calgranulin proteins S100A8, S100A9 and S100A12 are expressed in the inflamed gastric mucosa of Helicobacter pylori-infected children.
Canadian Journal of Gastroenterology. 22: 461-464.
Leach, S.T., Mitchell, H.M., Eng, W.R., Zhang, L. & Day, A.S. (2008)
Sustained modulation of intestinal bacteria by exclusive enteral nutrition used to treat children with Crohn's disease.
Alimentary Pharmacology & Therapeutics. 28: 724-733.
Mitchell, H., English, D.R., Elliott, F., Gengos, M., Barrett, J.H., Giles, G.G. and Forman, D. (2008)
Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer.
Alimentary Pharmacology and Therapeutics. 28: 903-910
Su, P., Henriksson, A., Nilsson, C. and Mitchell, H. (2008)
Synergistic effect of green tea extract and probiotics on the pathogenic bacteria, Staphylococcus aureus and Streptococcus pyogenes .
World Journal of Microbiology and Biotechnology. 24: 1837-1842.
Voravuthikunchai, S.P. & Mitchell, H. (2008)
Inhibitory and killing activities of medicinalplants against multiple antibiotic-resistant Helicobacter pylori .
Journal of Health Science. 54: 81-88.
Voravuthikunchai, S.P., & Mitchell, H.M. (2008)
Inhibitory and killing activities of medicinal plants against multiple antibiotic-resistant Helicobacter pylori.
Journal of Health Science. 54: 81-88.