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Teaching Responsibilities:Laboratory Website:Research Description:Our goal is to link the genotype with the phenotype using comparative genomics, population genetics, biochemical analyses, and life-history trait studies. Currently, our system of choice is the mitochondrial genome in Drosophila. From a biochemical perspective, we study the link between mitochondrial metabolism, aging and disease. A current goal is to determine whether mitochondrial bioenergetic efficiency, reactive oxygen species production and ageing is governed primarily by (i) mitochondrial DNA encoded genes, (ii) nuclear encoded genes that produce proteins imported into the mitochondrion, or (iii) interactions among mitochondrial and nuclear encoded proteins. From an evolutionary perspective we study the selective forces that influence the evolution mitochondrial DNA. Mitochondrial DNA has been widely employed as an evolutionary marker to study the process of molecular evolution and to infer phylogeographic and phylogenetic patterns.
Selected Publications:
Other Professional Activities:Adjunct Professor, Free Radical and Radiation Biology, University of Iowa, IA, U.S.A (2003-); Faculty of 1000 Reviewer (2002-); National Institute of Health Study Panel, D.C., U.S.A. (declined, 2006); Director, Roy. J. Carver Centre for Comparative Genomics (2001-2004); Associate Editor, Journal of Molecular Evolution (1999-2004); National Institute of Aging R03 Study Panel, D.C., U.S.A. (2004); Lecturer Committee on Evolutionary Biology, University of Chicago, IL, U.S.A. (1995-2001); Adjunct Associate Professor. University of Illinois at Chicago, IL, U.S.A. (1999-2002); Pritzker Chair of Biosystematics, The Field Museum, IL, U.S.A. (1998-2001); US/ Germany/ Japan TriNational Workshops on Molecular Evolution, Munich and Vancouver (1997-1998); National Science Foundation Systematic Biology Panel Member, D.C., U.S.A. (1998).
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