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Academic Staff Contact Details
Marc Wilkins

Professor Marc Wilkins

BSc (hons I), PhD

 

Room No:

Office 263C, Lab 264

Office:

2nd Flr, Biological Sciences Building UNSW Sydney NSW 2052

Phone:

9385 3633

Fax:

9385 1483

Email:

m.wilkins@unsw.edu.au 
Teaching Responsibilities:

BIOT 3071 Course Co-ordinator
BIOC 2101 Course Lecturer
BIOC 2201 Course Lecturer
BIOC2291 Course Lecturer
BIOC 3111 Course Lecturer
BIOC 3271 Course Lecturer
BIOT 3061 Course Lecturer
BIOT 7160 Course Lecturer
BINF 1001 Course Lecturer
BINF 2001 Course Lecturer
BINF 3001 Course Lecturer

Research Description:

Having defined the proteome in 1994 and coined the term, my research has continued to ask large-scale questions about protein function. We are currently examining the role of protein-protein interactions in the proteome, which can be called interactome research, and are exploring the following:

- What does the interactome look like? How can it best be visualised?
- What protein complexes exist? How can they be separated?
- Are protein complexes made of core, attachment and module proteins?
- What is the role of post-translational modifications in the interactome?
- How, when and why do proteins interact with each other? What are the dynamics of this process?
- How common is a loss or gain of protein-protein interaction in association with human disease?

We are exploring these questions using a combination of proteomic and bioinformatic techniques, analysing samples from numerous biological systems. We have access to FT-ICR, Q-star, Q-TOF and MALDI-TOF mass spectrometry at the on-site BMSF.

Selected Recent Publications:

Pang CNI, Hayen A, Wilkins MR (2007) Surface accessibility of  post-translational modifications. Journal of Proteome Research,  6: 1833-45.

Hsu W-T, Pang CNI, Sheetal J, Wilkins MR (2007) Protein-protein interactions and disease: use of S. cerevisiae as a model system. BBA Proteins and Proteomics, 1774: 838-47.

Wilkins MR, Appel RD, Williams KL, Hochstrasser DF (Eds.) (2007) Proteome Research: concepts, technology and application. Springer. (new book)

Taylor CF, Paton NW, Lilley KS, Binz PA, Julian RK, Jones AR, Zhu W, Apweiler R, Aebersold R, Deutsch EW, Macht M, Mann M, Neubert TA, Patterson SD, Seymour SL, Tsugita A, Wilkins MR, Xenarios I, Hermjakob H. (2007) The Minimum Information About a Proteomics Experiment (MIAPE). Nature Biotechnology, 25: 887-93.

Wilkins MR, Appel RD, Van Eyk JE, Chung MCM, Görg A, Hecker MA, Huber LA, Langen H, Link AJ,  Paik YK, Patterson SD, Pennington SR, Rabilloud T, Simpson RJ, Dunn MJ. (2006) Guidelines for the next 10 years of proteomics. Proteomics, 6, 4-8. Proteomics most accessed paper in 2006.
Other Professional Activities:

Co-founder of the ASX-listed biotechnology company Proteome Systems (www.proteomesystems.com ). Senior Editor for the journal Proteomics. Member of Advisory Boards for ARC Bioinformatics Centre of Excellence and Australian Proteomics Computational Facility. Member of Expert Task Force to advise Australian Government on Australia's current and future requirements in bioinformatics. Visiting Professor at Kurume University, Japan. Member of APS, ASBMB, DSB, HUPO.

 
 


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Page last updated: Monday, September 10th, 2007