Professional Experience

• Visiting Professorial Fellow, School of BABS 
• Prof., Istanbul Univ., Science Faculty 
• N.A.T.O. Postdoctoral Fellowship, Pennsylvania State Univ.
• Rectorate Scholarship for Doctoral Studies, LMU Munich. 

Research Contribution

Since my doctoral studies, my research interest has focused on bacterial metabolism and enzymology. Initially, I worked on the amino acid metabolism of a glutamic acid overproducing bacterium. In the1990s, my studies concentrated on the production, purification and the stabilization of penicillin G acylase from a mutant of E. coli. Over the last nine years, after collobarating with Prof. Rick Cavicchioli, I have started to work on the carbon and nitrogen metabolisms of oligotrophic and cold adapted prokaryotes such as S. alaskensis and M. burtonii, respectively. Since 2010, my project interest has progressed onto the kinetic and thermodynamic characterization of the functional properties of a hybrid versatile peroxidase from B. adjusta. Recently, I have focused on the proteases from cold adapted bacterial strains.

Publications

Ertan, H., Siddiqui, K.S., Muenchhoff, J., Charlton, T. & Cavicchioli, R. (2012)
Kinetic and thermodynamic characterization of the functional properties of a hybrid versatile peroxidase using isothermal titration calorimetry: insight into manganese peroxidase activation and lignin peroxidase inhibition.
Biochimie. 94(5): 1221-1231.

Cavicchioli, R., Charlton, T., Ertan, H., Mohd Omar, S., Siddiqui, K.S. & Williams, T.J. (2011)
Biotechnological uses of enzymes from psychrophiles.
Microbial Biotechnology. 4(4): 449-460.

Williams, T.J., Lauro, F.M., Ertan, H., Burg, D., Poljak, A., Raftery, M.J. & Cavicchioli, R. (2011)
Defining the response of a microorganism to growth semperature that spans its full growth temperature range (-2C to 28C) using multiplex quantitative proteomics.
Environmental Microbiology. 13(8): 2186-2203.

De Francisci, D., Campanaro, S., Kornfeld, G., Siddiqui, K.S., Williams, T.J., Ertan, H., Treu, L., Pilak, O., Lauro, F.M., Harrop, S.J., Curmi, P.M.G., Cavicchioli, R. (2011)
The RNA polymerase subunits E/F from the Antarctic archaeon, Methanococcoides burtonii bind to specific classes of mRNA.
Environmental Microbiology. 13(8): 2039-2055.

Williams, T., Burg, D., Ertan, H., Raftery, M., Poljak, A., Guilhaus, M. & Cavicchioli, R. (2010)
A global proteomic analysis of the insoluble, soluble and supernatant fractions of the psychrophilic archaeon Methanococcoides burtonii Part II: The effect of different methylated growth substrates.
Journal of Proteome Research. 9: 653-663.

Lauro, F.M., McDougald, D., Thomas, T., Williams, T.J., Egan, S., Rice, S., DeMaere, M.Z., Ting, L., Ertan, H., Johnson, J., Ferriera, S., Lapidus, A., Anderson, I., Kyrpides, N., Munk, A.C., Detter, C., Han, C.S., Brown, M.V., Robb, F.T., Kjelleberg, S. & Cavicchioli, R. (2009)
The genomic basis of trophic strategy in marine bacteria.
Proc Natl Acad Sci U S A. 106(37): 15527-15533.

Williams, T.J., Ertan, H., Ting, L. & Cavicchioli, R. (2009)
Carbon and nitrogen substrate utilization in the marine bacterium Sphingopyxis alaskensis strain RB2256.
ISME Journal. 3(9): 1036-1052.