Andrew Brown

Professor of Biochemistry
Professor

Biography

About Me

I am a Professor of Biochemistry in the School of Biotechnology and Biomolecular Sciences at UNSW Sydney where I teach on the biochemistry of fats (lipids) to science and medical students.  This has given me an interest in dietary fats, facts and fads, and I contribute the occasional article on these to The Conversation.

For the last couple of decades, my research has focused on one particular lipid which has become a by-word for heart disease risk, cholesterol. In fact, the cells in our body need cholesterol. However, too much cholesterol in our cells can cause disease, including heart disease. Therefore we have evolved an elaborate system for keeping the cholesterol content of our cells under tight-control. I had the privilege to work in the laboratory of Nobel laureates, Drs Joe Goldstein and Mike Brown in Dallas, who over the past three decades have revealed layer after layer of complexity of how cells regulate their cholesterol levels.

Since establishing my lab at UNSW, my talented team has made several major discoveries, including finding a link between an important signalling molecule (Akt) and cholesterol metabolism, as well as identifying squalene monooxygenase as a novel control point in cholesterol synthesis. These discoveries have lead our lab to investigate the molecular links between cholesterol and cancer (particularly prostate cancer), and the regulation of novel control points later in cholesterol synthesis, which have been largely overlooked until now.

Education

  • BSc Hons (University of Sydney) 1985
  • PhD (University of Sydney) 1991

Professional experience

  • 2018- current: Professor of Biochemistry
  • 2013-2018: Professor and Head of School, School of BABS
  • 2008-2012: Associate Professor, School of BABS
  • 2002-2008: Senior Lecturer, School of BABS, UNSW
  • 2000-2002: Visiting Scientist, UT Southwestern, Dallas
  • 1994-2000: Research Scientist/Project Leader, Heart Research Institute, Sydney
  • 1991-1994: Post-doctoral Research Fellow at The University of Edinburgh
  • 1987: Fellow, Department of Human Nutrition, The Agribultural University, Wageningen, The Netherlands

Research

"I <3 Cholesterol, but my <3 doesn't"

However, there's much much more to cholesterol than that. We study how we and our cells balance this Jekyll/Hyde molecule.

Cholesterol is notorious in human health and disease. It is both vital and lethal, depending on its levels, which are determined by several factors, including cholesterol synthesis. For the past decade, my lab has focused on investigating the control of cholesterol synthesis. We have made major progress, uncovering novel modes of regulation of enzymes beyond the best known and most intensively studied enzyme (HMGCR, target of the statin class of drugs). Notably, we discovered an important control point later in the pathway (squalene monooxygenase or epoxidase, SQLE), which has recently become the subject of intense interest as an oncogene and therapeutic target in several cancers.

Research goals

  • To discover new factors in achieving cholesterol balance in cells
  • To identify links between cholesterol and cancer

Specific projects

Cholesterol is a vital and versatile molecule that has become a byword for heart disease risk. In fact, the cells in our body actually need cholesterol, and too little results in devastating developmental disorders. However, too much can contribute to several diseases, including atherosclerosis and cancer. Our bodies have therefore engineered an elaborate system for keeping the cholesterol content of our cells tightly controlled. The overall goal of our research is to understand more about how our cells control cholesterol levels.

Project 1: New factors in achieving cholesterol balance

An imbalance of cholesterol plays a role in numerous diseases. Therefore, knowing precisely how cells regulate their cholesterol levels is central to understanding the development of these diseases, and to identify possible new treatments. Only one of the 20+ enzymes involved in cholesterol biosynthesis is targeted clinically (by statins). The statin class of drugs, worth >$30 billion a year, inhibit a very early step in cholesterol synthesis and have been effective in treating heart disease, but are not without their side effects. Very little attention has been paid to later steps in the pathway. This project will investigate the regulation of new control points in cholesterol synthesis, which have been largely overlooked in the past.

Project 2:  Cholesterol and cancer

Cancer is a disease characterised by increased cellular replication and spread beyond the normal location in the body. A hallmark feature of cancer cells is their abnormal metabolism compared to normal cells.  Notably, cells need cholesterol to grow and proliferate and mechanisms to accumulate cholesterol are far more common in cancer cells. Our lab discovered a connection between a major player involved in maintaining cholesterol balance in animal cells and a key proliferative pathway that is overactive in many cancers, including prostate cancer. This project investigates novel ways to modulate and decrease cellular cholesterol levels, which may inform the development of new anti-cancer therapies.

Methods routinely used in the lab

Mammalian cell culture, recombinant DNA techniques (cloning and mutagenesis), fluorescence microscopy, real-time PCR, gene/siRNA transfection, luciferase reporter assays, SDS-PAGE, Western blotting, and mass spectrometry.

Supervision Opportunities/Areas

Our lab provides a nurturing, supportive and stimulating research environment for students.

I have supervised 26 Honours students and all have received first class honours; 15 have gone on to do a PhD with me. Seven of my Honours students have received University medals (top of their cohort).

I have supervised 10 PhD students and all obtained excellent post-doc positions in Australia or overseas after completion.

I believe that a key part of my role as an academic is to mentor the next generation in scientific publishing, so I have an established record of converting student projects into publications. Many of my Honours students have had work from their Honours year published, and my PhD students publish at least 5 papers on average during their time with me.

Contact Andrew about research supervision opportunities: aj.brown@unsw.edu.au

Current PhD Students

  • Jake (Ngee Kiat) Chua
  • Nicola Scott
  • Isabelle Capell-Hattam
  • Hudson Coates
  • Lydia Qian

Current Post-doctoral researcher

  • Dr Laura Sharpe

Selected Publications

  • Gill S… Brown AJ. Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMGCR. Cell Metab 2011;13:260-73 [Cited 140] I led my team in the discovery of a novel control point in cholesterol synthesis: post-translational regulation of SQLE. Featured as cover story.
  • Zelcer N… Brown AJ. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase, and affects HMGCR and the cholesterol synthesis pathway. Mol Cell Biol 2014;34:562-70 [Cited 61] I led an international team to discover that one E3 ligase (MARCH6) targets 2 key control points in cholesterol synthesis, SQLE and HMGCR. Featured as a ‘Spotlight’ article and cover story.
  • Chua NK… Brown AJ. A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis. J Biol Chem 2017;292:19959-73. My team identified the shortest cholesterol-responsive degron (first 100 amino acids of SQLE), establishing a new mode of membrane cholesterol sensing. Editor’s pick (top 2% of accepted articles), accompanied by a commentary; selected for a JBC special issue (Feb 2018) as one of the most outstanding contributions from Australasia.
  • Sharpe LJ… Brown AJ. Cholesterol increases protein levels of the E3 ligase MARCH6, and thereby stimulates protein degradation. J Biol Chem 2019;294:2436-48. I initiated a collaboration with the Hochstrasser Lab at Yale (pioneers in protein degradation). We identified a new role for cholesterol in controlling protein demolition through stabilisation of the E3 ligase, MARCH6, opening up unexplored territory for regulation of cell homeostasis.
  • Meerman R, Brown AJ. When someone loses weight, where does the fat go? BMJ (2014 Christmas Issue) Collaborating with science communicator Ruben Meerman, we uncovered widespread ignorance of weight loss. Went ‘viral’ with Altmetric score >2200.
  • Brown AJ… Yan N. The shape of squalene epoxidase expands the arsenal against cancer. Nat Commun2019;10:888.  A commentary on recent studies of a key enzyme in cholesterol synthesis that our lab has studied extensively, co-authored by Nieng Yan, a world leading structural biologist from Princeton (and affiliated to UNSW).

Research Grants

  • Australian Research Council Discovery Project DP170101178, Navigating flux control through a branched metabolic pathway, Prof Brown, Prof Rogers, 2017-2020, $394,500
  • National Health and Medical Research Council Project APP1141938, The role of adipose tissue cholesterol in metabolic diseases, Prof Yang, Prof Brown, Prof Song, 2018-2021, $887,000
  • National Health and Medical Research Council Project APP1141939, Lipid trafficking at membrane contact sites: the role of Oxysterol-Binding Protein-Related Protein 5 and 8 (ORP5 and ORP8), Prof Yang, Prof Brown, Prof Wu, 2018-2020, $467,000

Awards and Achievements

  • 2012: Vice-Chancellor's Award for Teaching Excellence (Postgraduate Research Supervision)
  • 2012: Awarded first prize in the Poetry in Science contest run by the American Society for Biochemistry and Molecular Biology, published in the April issue of the magazine ASBMB Today
  • 2007-2009: Director of the Australian Society for Medical Research
  • 1987: International Agricultural Centre Research Fellowship
  • 1992: Young Scientist award from the British Nutrition Foundation
  • 1995: Young Investigator's award from the Oxygen Society (Pasadena, USA)
  • 1996: Travel award from the Sydney Free Radical Group

Professional affiliations and service positions

  • 2019- current Editorial Board of BBA-Molecular Cell Biology of Lipids
  • 2014- current Reviewing Editor of The Journal of Biological Chemistry
  • 2011- current: Member of the American Society of Biochemistry and Molecular Biology
  • 2009- current: Member of the Australian Society of Biochemistry and Molecular Biology
  • 2008-2010: National Director of the Australian Society for Medical Research
  • 2005-2008: Member of the NSW Executive of the Australian Society for Medical Research; Careers Day Organiser
  • 2004-2006: Newsletter Editor, Australian Atherosclerosis Society

Teaching

I contribute teaching into the following courses:
  • BIOC2101 Principles of Biochemistry (Advanced)
  • BABS2202 Molecular Cell Biology 1
  • BIOC3271 Molecular Cell Biology 2
  • BABS3281 Molecular Frontiers
  • BABS3261 Human Biochemistry (Co-convenor)
  • BABS3301 (Research project)
  • BABS Honours Year
  • Medical teaching (MFAC1501, 1522, 1523; Indigenous Pre-Med Program)
Journal articles
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Simonen P; Li S; Chua NK; Lampi AM; Piironen V; Lommi J; Sinisalo J; Brown AJ; Ikonen E; Gylling H, 2020, 'Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase', Journal of Internal Medicine, http://dx.doi.org/10.1111/joim.13095
2020
Scott NA; Sharpe LJ; Capell-Hattam IM; Gullo SJ; Luu W; Brown AJ, 2020, 'The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6', Biochemical Journal, vol. 477, pp. 541 - 555, http://dx.doi.org/10.1042/BCJ20190647
2020
Capell-Hattam IM; Brown AJ, 2020, 'Sterol Evolution: Cholesterol Synthesis in Animals Is Less a Required Trait Than an Acquired Taste', Current Biology, vol. 30, pp. R886 - R888, http://dx.doi.org/10.1016/j.cub.2020.06.007
2020
Capell-Hattam IM; Sharpe LJ; Qian L; Hart-Smith G; Prabhu AV; Brown AJ, 2020, 'Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally', Journal of Biological Chemistry, vol. 295, pp. 2850 - 2865, http://dx.doi.org/10.1074/jbc.RA119.011323
2020
Yoshioka H; Coates HW; Chua NK; Hashimoto Y; Brown AJ; Ohgane K, 2020, 'A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 7150 - 7158, http://dx.doi.org/10.1073/pnas.1915923117
2020
Chua NK; Coates HW; Brown AJ, 2020, 'Squalene monooxygenase: a journey to the heart of cholesterol synthesis', Progress in Lipid Research, vol. 79, pp. 101033, http://dx.doi.org/10.1016/j.plipres.2020.101033
2020
Chua NK; Brown AJ, 2020, 'Lipid sensing tips the balance for a key cholesterol synthesis enzyme.', J Lipid Res, pp. jlr.ILR120000801 - jlr.ILR120000801, http://dx.doi.org/10.1194/jlr.ILR120000801
2020
Brown AJ; Sharpe LJ; Rogers MJ, 2020, 'Oxysterols: From physiological tuners to pharmacological opportunities', British Journal of Pharmacology, http://dx.doi.org/10.1111/bph.15073
2020
Alrosan A; Aleidi SM; Yang A; Brown AJ; Gelissen IC, 2019, 'The adaptor protein alix is involved in the interaction between the ubiquitin ligase NEDD4-1 and its targets, ABCG1 and ABCG4', International Journal of Molecular Sciences, vol. 20, http://dx.doi.org/10.3390/ijms20112714
2019
Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, vol. 10, pp. 829, http://dx.doi.org/10.1038/s41467-019-08791-0
2019
Chua NK; Scott NA; Brown AJ, 2019, 'Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron', Biochemical Journal, vol. 476, pp. 2545 - 2560, http://dx.doi.org/10.1042/BCJ20190418
2019
Baker MAB; Brown AJ, 2019, 'A detour to sterol synthesis', Nature Microbiology, vol. 4, pp. 214 - 215, http://dx.doi.org/10.1038/s41564-018-0347-8
2019
Coates HW; Brown AJ, 2019, 'A Wolf in sheep’s clothing: Unmasking the lanosterol-induced degradation of HMG-CoA reductase1', Journal of Lipid Research, vol. 60, pp. 1643 - 1645, http://dx.doi.org/10.1194/jlr.C119000358
2019
Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, vol. 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y
2019
Chua NK; Hart-Smith G; Brown AJ, 2019, 'Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase', Journal of Biological Chemistry, vol. 294, pp. 8134 - 8147, http://dx.doi.org/10.1074/jbc.RA119.007798
2019
Coates HW; Chua NK; Brown AJ, 2019, 'Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1864, pp. 1656 - 1668, http://dx.doi.org/10.1016/j.bbalip.2019.08.006
2019
Sharpe LJ; Howe V; Scott NA; Luu W; Phan L; Berk JM; Hochstrasser M; Brown AJ, 2019, 'Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation', Journal of Biological Chemistry, vol. 294, pp. 2436 - 2448, http://dx.doi.org/10.1074/jbc.RA118.005069
2019
Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, vol. 294, pp. 19306 - 19321, http://dx.doi.org/10.1074/jbc.RA119.011160
2019
Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, vol. 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014
2019
Chua NK; Coates HW; Brown AJ, 2018, 'Cholesterol, cancer, and rebooting a treatment for athlete’s foot', Science Translational Medicine, vol. 10, http://dx.doi.org/10.1126/scitranslmed.aat3741
2018
Aleidi SM; Yang A; Sharpe LJ; Rao G; Cochran BJ; Rye KA; Kockx M; Brown AJ; Gelissen IC, 2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011
2018
Brown AJ; Gelissen IC, 2018, 'Cholesterol and desmosterol dancing to the beat of a different drug', Journal of Internal Medicine, vol. 283, pp. 102 - 105, http://dx.doi.org/10.1111/joim.12710
2018
Meerman R; Brown A, 2018, 'Why diets fail: Eating more, moving less', Postgraduate Medical Journal, vol. 94, pp. 65, http://dx.doi.org/10.1136/postgradmedj-2017-135153
2018
Chua NK; Brown AJ, 2018, 'Mallostery: Filling a niche between quality and metabolic control', Journal of Biological Chemistry, vol. 293, pp. 14951 - 14952, http://dx.doi.org/10.1074/jbc.H118.005031
2018
Chua NK; Brown AJ, 2018, 'Correction: Mallostery: Filling a niche between quality and metabolic control.', Journal of Biological Chemistry, vol. 293, pp. 16176, http://dx.doi.org/10.1074/jbc.AAC118.006017
2018
Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, vol. 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558
2018
Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00861-5
2017
Prabhu AV; Luu W; Brown AJ, 2017, 'Measuring activity of cholesterol synthesis enzymes using gas chromatography/mass spectrometry', Methods in Molecular Biology, vol. 1583, pp. 211 - 219, http://dx.doi.org/10.1007/978-1-4939-6875-6_16
2017
Gelissen IC; Brown AJ, 2017, 'An overview of cholesterol homeostasis', Methods in Molecular Biology, vol. 1583, pp. 1 - 6, http://dx.doi.org/10.1007/978-1-4939-6875-6_1
2017
Howe V; Sharpe LJ; Prabhu AV; Brown AJ, 2017, 'New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1862, pp. 647 - 657, http://dx.doi.org/10.1016/j.bbalip.2017.03.009
2017
Howe V; Brown AJ, 2017, 'Determining the topology of membrane-bound proteins using PEGylation', Methods in Molecular Biology, vol. 1583, pp. 201 - 210, http://dx.doi.org/10.1007/978-1-4939-6875-6_15
2017
Luu W; Gelissen IC; Brown AJ, 2017, 'Manipulating cholesterol status within cells', Methods in Molecular Biology, vol. 1583, pp. 41 - 52, http://dx.doi.org/10.1007/978-1-4939-6875-6_4
2017
Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2017, 'Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis', Journal of Steroid Biochemistry and Molecular Biology, vol. 165, pp. 363 - 368, http://dx.doi.org/10.1016/j.jsbmb.2016.08.003
2017
Sharpe LJ; Brown AJ, 2017, 'Identifying sterol response elements within promoters of genes', Methods in Molecular Biology, vol. 1583, pp. 185 - 191, http://dx.doi.org/10.1007/978-1-4939-6875-6_13
2017
Caruana BT; Skoric A; Brown AJ; Lutze-Mann LH, 2017, 'Site-1 protease, a novel metabolic target for glioblastoma', Biochemical and Biophysical Research Communications, vol. 490, pp. 760 - 766, http://dx.doi.org/10.1016/j.bbrc.2017.06.114
2017
Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2017, 'A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis', Journal of Biological Chemistry, vol. 292, pp. 19959 - 19973, http://dx.doi.org/10.1074/jbc.M117.794230
2017
Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', Journal of Biological Chemistry, vol. 291, pp. 8363 - 8376, http://dx.doi.org/10.1074/jbc.M115.699546
2016
Brown AJ; Hsieh J, 2016, 'Foiling IDOL to help control cholesterol', Circulation Research, vol. 118, pp. 371 - 373, http://dx.doi.org/10.1161/CIRCRESAHA.116.308191
2016
Luu W; Sharpe LJ; Capell-Hattam I; Gelissen IC; Brown AJ, 2016, 'Oxysterols: Old Tale, New Twists', Annual Review of Pharmacology and Toxicology, vol. 56, pp. 447 - 467, http://dx.doi.org/10.1146/annurev-pharmtox-010715-103233
2016
Howe V; Sharpe LJ; Alexopoulos SJ; Kunze SV; Chua NK; Li D; Brown AJ, 2016, 'Cholesterol homeostasis: How do cells sense sterol excess?', Chemistry and Physics of Lipids, vol. 199, pp. 170 - 178, http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011
2016
Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', IMMUNOLOGY AND CELL BIOLOGY, vol. 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58
2016
Loregger A; Cook ECL; Nelson JK; Moeton M; Sharpe LJ; Engberg S; Karimova M; Lambert G; Brown AJ; Zelcer N, 2016, 'A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes', Molecular and Cellular Biology, vol. 36, pp. 285 - 294, http://dx.doi.org/10.1128/MCB.00890-15
2016
Prabhu AV; Luu W; Li D; Sharpe LJ; Brown AJ, 2016, 'DHCR7: A vital enzyme switch between cholesterol and vitamin D production', Progress in Lipid Research, vol. 64, pp. 138 - 151, http://dx.doi.org/10.1016/j.plipres.2016.09.003
2016
Aleidi SM; Howe V; Sharpe LJ; Yang A; Rao G; Brown AJ; Gelissen IC, 2015, 'The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters', Journal of Biological Chemistry, vol. 290, pp. 24604 - 24613, http://dx.doi.org/10.1074/jbc.M115.675579
2015
Stevenson J; Brown AJ, 2015, 'Universal CG cloning of polymerase chain reaction products', Analytical biochemistry, vol. 471, pp. 80 - 82, http://dx.doi.org/10.1016/j.ab.2014.10.018
2015
Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites', Current Opinion in Cell Biology, vol. 35, pp. 37 - 42, http://dx.doi.org/10.1016/j.ceb.2015.04.002
2015
Howe V; Chua NK; Stevenson J; Brown AJ, 2015, 'The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change', Journal of Biological Chemistry, vol. 290, pp. 27533 - 27544, http://dx.doi.org/10.1074/jbc.M115.675181
2015
Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602
2015
Rye KA; Barter PJ; Brown AJ, 2015, 'Speed kills in more ways than one: Methamphetamine and atherosclerosis', Atherosclerosis, vol. 243, pp. 654 - 655, http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.034
2015
Sharpe LJ; Howe V; Prabhu AV; Luu W; Brown AJ, 2015, 'Navigating the shallows and rapids of cholesterol synthesis downstream of HMGCR', Journal of Nutritional Science and Vitaminology, vol. 61, pp. S154 - S156, http://dx.doi.org/10.3177/jnsv.61.S154
2015
Moon H; Ruelcke JE; Choi E; Sharpe LJ; Nassar ZD; Bielefeldt-Ohmann H; Parat MO; Shah A; Francois M; Inder KL; Brown AJ; Russell PJ; Parton RG; Hill MM, 2015, 'Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1', Oncotarget, vol. 6, pp. 7438 - 7453, http://dx.doi.org/10.18632/oncotarget.3476
2015
Luu W; Hart-Smith G; Sharpe LJ; Brown AJ, 2015, 'The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally', Journal of Lipid Research, vol. 56, pp. 888 - 897, http://dx.doi.org/10.1194/jlr.M056986
2015
Sharpe LJ; Rao G; Jones PM; Glancey E; Aleidi SM; George AM; Brown AJ; Gelissen IC, 2015, 'Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1851, pp. 956 - 964, http://dx.doi.org/10.1016/j.bbalip.2015.02.016
2015
Prabhu AV; Sharpe LJ; Brown AJ, 2014, 'The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1841, pp. 1431 - 1439, http://dx.doi.org/10.1016/j.bbalip.2014.07.006
2014
Meerman R; Brown AJ, 2014, 'When somebody loses weight, where does the fat go?', BMJ (Online), vol. 349, http://dx.doi.org/10.1136/bmj.g7257
2014
Tint GS; Pan L; Shang Q; Sharpe LJ; Brown AJ; Li M; Yu H, 2014, 'Desmosterol in brain is elevated because DHCR24 Needs REST for robust expression but REST is poorly expressed', Developmental Neuroscience, vol. 36, pp. 132 - 142, http://dx.doi.org/10.1159/000362363
2014
Moon H; Hill MM; Roberts MJ; Gardiner RA; Brown AJ, 2014, 'Statins: protectors or pretenders in prostate cancer?', Trends in Endocrinology & Metabolism, vol. 25, pp. 188 - 196, http://dx.doi.org/10.1016/j.tem.2013.12.007
2014
Brown AJ; Ikonen E; Olkkonen VM, 2014, 'Cholesterol precursors: More than mere markers of biosynthesis', Current Opinion in Lipidology, vol. 25, pp. 133 - 139, http://dx.doi.org/10.1097/MOL.0000000000000038
2014
Hsieh V; Kim MJ; Gelissen IC; Brown AJ; Sandoval C; Hallab JC; Kockx M; Traini M; Jessup W; Kritharides L, 2014, 'Cellular cholesterol regulates ubiquitination and degradation of the cholesterol export proteins ABCA1 and ABCG1', Journal of Biological Chemistry, vol. 289, pp. 7524 - 7536, http://dx.doi.org/10.1074/jbc.M113.515890
2014
Sharpe LJ; Cook ECL; Zelcer N; Brown AJ, 2014, 'The UPS and downs of cholesterol homeostasis', Trends in Biochemical Sciences, vol. 39, pp. 527 - 535, http://dx.doi.org/10.1016/j.tibs.2014.08.008
2014
Sharpe LJ; Burns V; Brown AJ, 2014, 'A Lipidomic Perspective on Intermediates in Cholesterol Synthesis as Indicators of Disease Status', Journal of Genetics and Genomics, vol. 41, pp. 275 - 282, http://dx.doi.org/10.1016/j.jgg.2014.03.001
2014
Luu W; Zerenturk EJ; Kristiana I; Bucknal MP; Sharpe LJ; Brown AJ, 2014, 'Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesi[s]', Journal of Lipid Research, vol. 55, pp. 410 - 420, http://dx.doi.org/10.1194/jlr.M043257
2014
Meerman R; Brown A, 2014, 'When somebody loses weight, where does the fat go? (vol 349, pg g7257, 2014)', BMJ-BRITISH MEDICAL JOURNAL, vol. 349, http://dx.doi.org/10.1136/bmj.g7782
2014
Zelcer N; Sharpe LJ; Loregger A; Kristiana I; Cook ECL; Phan L; Stevenson J; Brown AJ, 2014, 'The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and the cholesterol synthesis pathway', Molecular and Cellular Biology, vol. 34, pp. 1262 - 1270, http://dx.doi.org/10.1128/MCB.01140-13
2014
Zerenturk EJ; Sharpe LJ; Brown AJ, 2014, 'DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: Implications for the activities of this multi-functional enzyme', Bioscience Reports, vol. 34, pp. 107 - 117, http://dx.doi.org/10.1042/BSR20130127
2014
Stevenson J; Luu W; Kristiana I; Brown AJ, 2014, 'Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids', Biochemical Journal, vol. 461, pp. 435 - 442, http://dx.doi.org/10.1042/BJ20131404
2014
Thukral L; Brown AJ, 2013, 'Lipid-protein interactions in membranes: implications for health and disease', Journal of Clinical Lipidology, vol. 8, pp. 43 - 45, http://dx.doi.org/10.2217/clp.12.85
2013
Prabhu AV; Krycer JR; Brown AJ, 2013, 'Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells', FEBS Letters, vol. 587, pp. 983 - 988, http://dx.doi.org/10.1016/j.febslet.2013.02.040
2013
Stevenson J; Krycer JR; Phan L; Brown AJ, 2013, 'A practical comparison of ligation-independent cloning techniques', PLoS ONE, vol. 8, pp. e83888 - e83888, http://dx.doi.org/10.1371/journal.pone.0083888
2013
Zerenturk EJ; Sharpe LJ; Ikonen E; Brown AJ, 2013, 'Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis', Progress in Lipid Research, vol. 52, pp. 666 - 680, http://dx.doi.org/10.1016/j.plipres.2013.09.002
2013
Sharpe LJ; Brown AJ, 2013, 'Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)', Journal of Biological Chemistry, vol. 288, pp. 18707 - 18715, http://dx.doi.org/10.1074/jbc.R113.479808
2013
Du X; Kazim AS; Dawes IW; Brown AJ; Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, vol. 14, pp. 107 - 119, http://dx.doi.org/10.1111/tra.12015
2013
Krycer JR; Brown AJ, 2013, 'Cholesterol accumulation in prostate cancer: A classic observation from a modern perspective', Biochimica et Biophysica ACTA - Reviews on Cancer, vol. 1835, pp. 219 - 229, http://dx.doi.org/10.1016/j.bbcan.2013.01.002
2013
Luu W; Sharpe LJ; Gelissen IC; Brown AJ, 2013, 'The role of signalling in cellular cholesterol homeostasis', IUBMB Life, vol. 65, pp. 675 - 684, http://dx.doi.org/10.1002/iub.1182
2013
Luu W; Sharpe LJ; Brown AJ, 2013, 'Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression', Atherosclerosis, vol. 228, pp. 362 - 369, http://dx.doi.org/10.1016/j.atherosclerosis.2013.03.016
2013
Ta MT; Kapterian T; Fei W; Du X; Brown AJ; Dawes IW; Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS Journal, vol. 279, pp. 4231 - 4244, http://dx.doi.org/10.1111/febs.12015
2012
Gelissen IC; Sharpe LJ; Sandoval C; Rao G; Kockx M; Kritharides L; Jessup WK; Brown AJP, 2012, 'Protein kinase A modulates the activity of a major human isoform of ABCG1', Journal of Lipid Research, vol. 53, pp. 2133 - 2140, http://dx.doi.org/10.1194/jlr.M028795
2012
Du X; Kazim A; Brown AJ; Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking', Cell Reports, vol. 1, pp. 29 - 35, http://dx.doi.org/10.1016/j.celrep.2011.10.004
2012
Brown AJ, 2012, 'Cholesterol versus other sterols: How do they compare as physiological regulators of cholesterol homeostasis?', European Journal of Lipid Science and Technology, vol. 114, pp. 617 - 623, http://dx.doi.org/10.1002/ejlt.201100295
2012
Zerenturk EJ; Sharpe LJ; Brown AJ, 2012, 'Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by sterol regulatory element binding proteins.', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, vol. 1821, pp. 1350 - 1360, http://dx.doi.org/10.1016/j.bbalip.2012.07.006
2012
Krycer JR; Brown AJ, 2012, 'Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis?', PLoS One, vol. 8, pp. e54007, http://dx.doi.org/10.1371/journal.pone.0054007
2012
Jansen M; Wang W; Greco D; Bellenchi GC; Di Porzio U; Brown AJ; Ikonen E, 2012, 'What dictates the accumulation of desmosterol in the developing brain?', The FASEB Journal, vol. 27, pp. 865 - 870, http://dx.doi.org/10.1096/fj.12-211235
2012
Kristiana I; Luu W; Stevenson J; Cartland SP; Jessup W; Belani JD; Rychnovsky SD; Brown AJP, 2012, 'Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses', The Journal of Biological Chemistry, vol. 287, pp. 33897 - 33904, http://dx.doi.org/10.1074/jbc.M112.360537
2012
Kockx M; Dinnes DL; Huang K; Sharpe LJ; Jessup W; Brown AJ; Kritharides L, 2012, 'Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: Studies of apolipoprotein E and VSVGt', Biochemical Journal, vol. 447, pp. 51 - 60, http://dx.doi.org/10.1042/BJ20111891
2012
Krycer JR; Phan L; Brown AJ, 2012, 'A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products', Biochemical Journal, vol. 446, pp. 191 - 201, http://dx.doi.org/10.1042/BJ20120545
2012
Burns V; Sharpe LJ; Gelissen IC; Brown AJ, 2012, 'Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function', Atherosclerosis, vol. 226, pp. 408 - 411, http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.009
2012
Zerenturk EJ; Kristiana I; Gill S; Brown AJ, 2012, 'The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, vol. 1821, pp. 1269 - 1277, http://dx.doi.org/10.1016/j.bbalip.2011.11.009
2012
Gelissen IC; Brown AJ, 2012, 'Highlights from the latest articles in statin pharmacogenomics: Predicting response to statins by pharmacogenetic testing.', Pharmacogenomics, vol. 13, pp. 1223 - 1225, http://dx.doi.org/10.2217/pgs.12.107
2012
Luu W; Sharpe LJ; Stevenson J; Brown AJ, 2012, 'Akt acutely activates the cholesterogenic transcription factor SREBP-2.', Biochimica et Biophysica ACTA - Molecular Cell Research, vol. 1823, pp. 458 - 464, http://dx.doi.org/10.1016/j.bbamcr.2011.09.017
2012
Sharpe LJ; Wong J; Garner B; Halliday GM; Brown AJ, 2012, 'Is seladin-1 really a selective Alzheimer's disease indicator?', Journal of Alzheimer's Disease, vol. 30, pp. 35 - 39, http://dx.doi.org/10.3233/JAD-2012-111955
2012
Gill S; Brown AJ, 2011, 'Exploiting a physiological regulator to improve the efficacy and safety of statins', Cardiovascular Drugs and Therapy, vol. 25, pp. 183 - 185, http://dx.doi.org/10.1007/s10557-011-6281-0
2011
Sharpe LJ; Luu W; Brown AJ, 2011, 'Akt phosphorylates Sec24: New clues into the regulation of ER-to-Golgi trafficking', Traffic (Malden), vol. 12, pp. 19 - 27, http://dx.doi.org/10.1111/j.1600-0854.2010.01133.x
2011
Gelissen IC; Brown AJ, 2011, 'Drug targets beyond HMG-CoA reductase: Why venture beyond the statins?', Frontiers in Biology, vol. 6, pp. 197 - 205, http://www.springerlink.com/content/f128456281471166/
2011
Fei W; Li H; Shui G; Kapterian TS; Bielby C; Du X; Brown AJ; Li P; Wenk M; Liu P; Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', Journal of Lipid Research, vol. 52, pp. 2136 - 2147, http://dx.doi.org/10.1194/jlr.M017566
2011
Krycer JR; Brown AJ, 2011, 'Cross-talk between the androgen receptor and the liver X receptor: Implications for cholesterol homeostasis', The Journal of Biological Chemistry, vol. 286, pp. 20637 - 20647, http://dx.doi.org/10.1074/jbc.M111.227082
2011
Sharpe LJ; Eden J-S; White PA; Brown AJ, 2011, 'Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt', Journal of Virology, vol. 85, pp. 10894 - 10898, http://dx.doi.org/10.1128/JVI.05562-11
2011
Fei W; Shui G; Zhang Y; Krahmer N; Ferguson C; Kapterian T; Lin RCY; Dawes IW; Brown AJ; Li P; Huang X; Parton R; Wenk M; Walther TC; Yang H, 2011, 'A role for phosphatidic acid in the formation of “supersized” lipid droplets', PLOS Genetics, vol. 7, pp. e1002201 1 - e1002201 11, http://dx.doi.org/10.1371/journal.pgen.1002201
2011
Du XR; Kumar J; Ferguson C; Schulz TA; Ong YS; Hong W; Prinz WA; Parton RG; Brown AJ; Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking', Journal of Cell Biology, vol. 192, pp. 121 - 135, http://dx.doi.org/10.1083/jcb.201004142
2011
Brown AJ, 2011, 'Isoprenoid is a perfect fit for fat factor', Biochemical Journal, vol. 438, pp. e1 - e3, http://dx.doi.org/10.1042/BJ20110996
2011
Appelqvist H; Nilsson C; Garner B; Brown AJ; Kagedal K; Ollinger KM, 2011, 'Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation', American Journal of Pathology, vol. 178, pp. 629 - 639, http://dx.doi.org/10.1016/j.ajpath.2010.10.030
2011
Gill S; Stevenson J; Kristiana I; Brown AJ, 2011, 'Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase', Cell Metabolism, vol. 13, pp. 260 - 273, http://dx.doi.org/10.1016/j.cmet.2011.01.015
2011
Wiklund ED; Catts VS; Catts SV; Ng TF; Whitaker NJ; Brown AJ; Lutze-Mann L, 2010, 'Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target.', International Journal of Cancer, vol. 126, pp. 28 - 40, http://dx.doi.org/10.1002/ijc.24813
2010
Brown AJ; Galea AM, 2010, 'Cholesterol as an evolutionary response to living with oxygen.', Evolution, vol. 64, pp. 2179 - 2183, http://dx.doi.org/10.1111/j.1558-5646.2010.01011.x
2010
Brown AJ, 2010, 'Does upsizing statins have a downside?', Drug Safety, vol. 33, pp. 435 - 436, http://dx.doi.org/10.2165/11532370-000000000-00000
2010
Gelissen I; Cartland SP; Brown AJ; Sandoval C; Lee Y; Dinnes DL; Hsieh V; Kritharides L; Jessup W; Gaus K, 2010, 'Expression and stability of two isoforms of ABCG1 in human vascular cells.', Atherosclerosis, vol. 208, pp. 75 - 82, http://dx.doi.org/10.1016/j.atherosclerosis.2009.06.028
2010
Kristiana I; Sharpe LJ; Catts VS; Lutze-mann LH; Brown AJ, 2010, 'Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol.', Journal of Pharmacogenomics, vol. 10, pp. 396 - 407, http://dx.doi.org/10.1038/tpj.2009.62
2010
Krycer JR; Sharpe LJ; Luu W; Brown AJ, 2010, 'The Akt-SREBP nexus: cell signaling meets lipid metabolism.', Trends in Endocrinology and Metabolism, vol. 21, pp. 268 - 278, http://dx.doi.org/10.1016/j.tem.2010.01.001
2010
Krycer JR; Brown AJ, 2009, 'Putative Fat Fighter Hits the Middle Man', Chemistry and biology, vol. 16, pp. 798 - 800, http://dx.doi.org/10.1016/j.chembiol.2009.08.003
2009
Brown AJ; Jessup W, 2009, 'Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis', Molecular Aspects of Medicine, vol. 30, pp. 111 - 122, http://dx.doi.org/10.1016/j.mam.2009.02.005
2009
Brown AJ; Kristiana I; Krycer JR, 2009, 'Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCap and PC-3.', PLoS One, vol. 4, pp. e8496, http://dx.doi.org/10.1371/journal.pone.0008496
2009
Brown AJ, 2009, '24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis', International Journal of Biochemistry and Cell Biology, vol. 41, pp. 744 - 747, http://dx.doi.org/10.1016/j.biocel.2008.05.029
2009
Galea AM; Brown AJ, 2009, 'Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?', Free Radical Biology and Medicine, vol. 47, pp. 880 - 889, http://dx.doi.org/10.1016/j.freeradbiomed.2009.06.027
2009
Stevenson J; Brown AJ, 2009, 'How essential is cholesterol?', Biochemical Journal, vol. 420, http://dx.doi.org/10.1042/BJ20090445
2009
Yan DB; Mayranpaa M; Wong J; Perttila J; Lehto M; Jauhiainen M; Kovanen P; Ehnholm C; Brown AJ; Olkkonen V, 2008, 'OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages', The Journal of Biological Chemistry, vol. 283, pp. 332 - 340, http://dx.doi.org/10.1074/jbc.M705313200
2008
Wong J; Quinn CM; Gelissen I; Brown AJ, 2008, 'Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis', The Journal of Biological Chemistry, vol. 283, pp. 700 - 707, http://dx.doi.org/10.1074/jbc.M706416200
2008
Brown AJ, 2008, 'Viral hepatitis and fatty liver disease: how an unwelcome guest makes pate of the host', Biochemical Journal, vol. 416, pp. e15 - e17, http://dx.doi.org/10.1042/BJ20081916
2008
Sharpe LJ; Brown AJ, 2008, 'Rapamycin down-regulates LDL-receptor expression independently of SREBP-2', Biochemical and Biophysical Research Communications, vol. 373, pp. 670 - 674, http://dx.doi.org/10.1016/j.bbrc.2008.06.108
2008
Kristiana I; Yang H; Brown AJ, 2008, 'Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: Implications for cholesterol trafficking to the endoplasmic reticulum', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, vol. 1781, pp. 724 - 730, http://dx.doi.org/10.1016/j.bbalip.2008.08.006
2008
Sharpe LJ; Du X; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-golgi transport', Methods in Molecular Biology, vol. 457, pp. 215 - 225, http://dx.doi.org/10.1007/978-1-59745-261-8_16
2008
Gill S; Chow R; Brown AJ, 2008, 'Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised', Progress in Lipid Research, vol. 47, pp. 391 - 404, http://dx.doi.org/10.1016/j.plipres.2008.04.002
2008
McCarthy F; Brown AJ, 2008, 'Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells', Biochemical and Biophysical Research Communications, vol. 373, pp. 109 - 112, http://dx.doi.org/10.1016/j.bbrc.2008.05.169
2008
Wong J; Quinn CM; Gelissen I; Jessup W; Brown AJ, 2008, 'The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation', Atherosclerosis, vol. 196, pp. 180 - 189, http://dx.doi.org/10.1016/j.atherosclerosis.2007.03.030
2008
Fei W; Shui G; Gaeta BA; Du XR; Kuerschner L; Liu P; Brown AJ; Wenk M; Parton R; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast', Journal of Cell Biology, vol. 180, pp. 473 - 482, http://dx.doi.org/10.1083/icb.200711136
2008
Wong J; Quinn CM; Guillemin GJ; Brown AJ, 2007, 'Primary human astrocytes product 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis', Journal of Neurochemistry, vol. 103, pp. 1764 - 1773, http://dx.doi.org/10.1111/j.1471-4159.2007.04913.x
2007
Brown AJ, 2007, 'Low-carb diets, fasting and euphoria: Is there a link between ketosis and y-hydroxybutyrate (GHB)?', Journal of Medical Hypotheses, vol. 68, pp. 268 - 271, http://dx.doi.org/10.1016/j.mehy.2006.07.043
2007
Yan DB; Mayranpaa M; Wong J; Perttila J; Lehto M; Jauhiainen M; Kovanen P; Ehnholm C; Brown AJ; Olkkonen V, 2007, 'OSBP-related protein 8 (ORP8) regulates ABCA1 expression and cholesterol efflux to apolipoprotein A-I', Chemistry and Physics of Lipids, vol. 149, pp. S73 - S73, http://dx.doi.org/10.1016/j.chemphyslip.2007.06.166
2007
Brown AJ, 2007, 'Cholesterol, statins and cancer', Clinical and Experimental Pharmacology and Physiology, vol. 34, pp. 135 - 141, http://dx.doi.org/10.1111/j.1440-1681.2007.04565.x
2007
Wong J; Quinn CM; Brown AJ, 2007, 'Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol', Lipids in Health and Disease, vol. 6, http://dx.doi.org/10.1186/1476-511X-6-10
2007
Jessup W; Brown AJ; van Reyk DM; Mattsson Hult en L; Dean RT, 2006, 'Oxysterols in biological systems: sources, metabolism and pathophysiological relevance', Redox Report, vol. 11, pp. 255 - 262, http://dx.doi.org/10.1179/135100006X155003
2006
Wong J; Quinn CM; Brown AJ, 2006, 'SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR', Biochemical Journal, vol. 400, pp. 485 - 491, http://dx.doi.org/10.1042/BJ20060914
2006
Du XR; Kristiana I; Wong J; Brown AJ, 2006, 'Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: A link between a key cell proliferative pathway and membrane synthesis', Molecular Biology of the Cell, vol. 17, pp. 2735 - 2745, http://dx.doi.org/10.1091/mbc.E05-11-1094
2006
Jessup W; Gelissen I; Kritharides L; Quinn CM; Kockx M; Brown AJ; Rye K; Harris M; Packianathan M; Cartland SP, 2006, 'ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 26, pp. 534 - 540, http://dx.doi.org/10.1161/01.ATV.0000200082.58536.e1
2006
Brown AJ; Wong J; Quinn CM, 2005, 'Human macrophages can synthesise de novo an oxysterol ligand for the liver X receptor: Effects of statins and consequences for cholesterol efflux', Atherosclerosis Supplements, vol. 6, pp. 96 - 96, http://dx.doi.org/10.1016/S1567-5688(05)80379-4
2005
Jessup W; Brown AJ, 2005, 'Novel routes for metabolism of 7-Ketocholesterol', Rejuvenation Research, vol. 8, pp. 9 - 12, http://dx.doi.org/10.1089/rej.2005.8.9
2005
Quinn CM; Jessup W; Wong J; Kritharides L; Brown AJ, 2005, 'Expression and regulation of sterol 27-hydroxylase (CYP27A1) in humanmacrophages: a role for RXR and PPAR gamma ligands', Biochemical Journal, vol. 385, pp. 823 - 830, http://dx.doi.org/10.1042/BJ20041776
2005
Wong J; Quinn CM; Brown AJ, 2004, 'Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 24, pp. 2365 - 2371, http://dx.doi.org/10.1161/01.ATV.0000148707.93054.7d
2004
Brown AJ, 2004, 'Of cholesterol-free mice and men', Current Opinion in Lipidology, vol. 15, pp. 373 - 375, http://dx.doi.org/10.1097/00041433-200406000-00021
2004
Du XR; Pham Y; Brown AJ, 2004, 'Effects of 25-hydroxycholesterol on cholesterol esterification andsterol regulatory element-binding protein processing are dissociable -Implications for cholesterol movement to the regulatory pool in theendoplasmic reticulum', The Journal of Biological Chemistry, vol. 279, pp. 47010 - 47016, http://dx.doi.org/10.1074/jbc.M408690200
2004
Jessup W; Quinn CM; Brown AJ; Kritharides L, 2003, 'Expression and regulation of sterol 27-hydroxylase (CYP27A1) in humanmacrophages', Atherosclerosis Supplements, vol. 4, pp. 219 - 219, http://dx.doi.org/10.1016/S1567-5688(03)90935-4
2003
Upston JM; Niu X; Brown AJ; Mashima R; Wang H; Senthilmohan R; Kettle AJ; Dean RT; Stocker R, 2002, 'Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis', American Journal of Pathology, vol. 160, pp. 701 - 710, http://dx.doi.org/10.1016/S0002-9440(10)64890-0
2002
Lyons MA; Maeda N; Brown AJ, 2002, 'Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1581, pp. 119 - 126, http://dx.doi.org/10.1016/S1388-1981(02)00156-7
2002
Brown AJ; Sun L; Feramisco JD; Brown MS; Goldstein JL, 2002, 'Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism', Molecular Cell, vol. 10, pp. 237 - 245, http://dx.doi.org/10.1016/S1097-2765(02)00591-9
2002
Brown AJ, 2002, 'Atherosclerosis: cell biology and lipoproteins: cholesterol absorption inhibitors: gateway therapy for hypercholesterolaemia', Current Opinions in Lipidology, vol. 13, pp. 701 - 703, http://dx.doi.org/10.1097/00041433-200212000-00016
2002
Lyons MA; Brown AJ, 2001, '7-Ketocholesterol delivered to mice in chylomicron remnant-like particles is rapidly metabolised, excreted and does not accumulate in aorta', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1530, pp. 209 - 218, http://dx.doi.org/10.1016/S1388-1981(01)00083-X
2001
Lyons MA; Maeda N; Brown AJ, 2001, '7-ketocholesterol metabolism is dependent upon sterol 27-hydroxylase in human hepatic cells but not in sterol 27-hydroxylase knockout mice.', HEPATOLOGY, vol. 34, pp. 471A - 471A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171224701188&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2001
Brown AJ, 2001, 'Atherosclerosis: Cell biology and lipoproteins', Current Opinion in Lipidology, vol. 12, pp. 671 - 673, http://dx.doi.org/10.1097/00041433-200112000-00012
2001
Thomas SR; Leichtweis SB; Pettersson K; Croft KD; Mori TA; Brown AJ; Stocker R, 2001, 'Dietary cosupplementation with vitamin E and coenzyme Q10 inhibits atherosclerosis in apolipoprotein E gene knockout mice', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, pp. 585 - 593, http://dx.doi.org/10.1161/01.ATV.21.4.585
2001
Hamilton JA; Jessup W; Brown AJ; Whitty G, 2001, 'Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL', Biochemical Journal, vol. 355, pp. 207 - 214, http://dx.doi.org/10.1042/bj3550207
2001
Burnett JR; Moses EA; Croft KD; Brown AJ; Grainger K; Vasikaran SD; Leitersdorf E; Watts GF, 2001, 'Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis', Clinica Chimica Acta, vol. 306, pp. 63 - 69, http://dx.doi.org/10.1016/S0009-8981(01)00391-6
2001
Lyons MA; Brown AJ, 2001, 'Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells', Lipids, vol. 36, pp. 701 - 711, http://dx.doi.org/10.1007/s11745-001-0775-8
2001
Upston JM; Witting PK; Brown AJ; Stocker R; Keaney JF, 2001, 'Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits', Free Radical Biology and Medicine, vol. 31, pp. 1245 - 1253, http://dx.doi.org/10.1016/S0891-5849(01)00721-3
2001
Gatto LM; Lyons MA; Brown AJ; Samman S, 2001, 'Trans fatty acids and cholesterol metabolism: Mechanistic studies in rats and rabbits fed semipurified diets', International Journal of Food Sciences and Nutrition, vol. 52, pp. 435 - 441, http://dx.doi.org/10.1080/09637480120078320
2001
Sleer LS; Brown AJ; Stanley K, 2001, 'Interaction of caveolin with 7-ketocholesterol', Atherosclerosis, vol. 159, pp. 49 - 55, http://dx.doi.org/10.1016/S0021-9150(01)00486-5
2001
Brown AJ; Mander EL; Gelissen IC; Kritharides L; Dean RT; Jessup W, 2000, 'Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells: Accumulation of oxidized esters in lysosomes', Journal of Lipid Research, vol. 41, pp. 226 - 236
2000
Brown AJ; Watts GF; Burnett JR; Dean RT; Jessup W, 2000, 'Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture', Journal of Biological Chemistry, vol. 275, pp. 27627 - 27633, http://dx.doi.org/10.1074/jbc.M004060200
2000
Brown AJ, 2000, 'Atherosclerosis: Cell biology and lipoproteins', Current Opinion in Lipidology, vol. 11, pp. 667 - 669, http://dx.doi.org/10.1097/00041433-200012000-00016
2000
Lyons MA; Samman S; Gatto L; Brown AJ, 1999, 'Rapid hepatic metabolism of 7-ketocholesterol in vivo: Implications for dietary oxysterols', Journal of Lipid Research, vol. 40, pp. 1846 - 1857
1999
Brown AJ; Jessup W, 1999, 'Oxysterols and atherosclerosis', Atherosclerosis, vol. 142, pp. 1 - 28, http://dx.doi.org/10.1016/S0021-9150(98)00196-8
1999
Brown AJ, 1999, 'What's sex got to do with it?', Current opinion in lipidology, vol. 10, pp. 641 - 644, http://dx.doi.org/10.1097/00041433-199912000-00022
1999
Lyons MA; Brown AJ, 1999, '7-Ketocholesterol', International Journal of Biochemistry and Cell Biology, vol. 31, pp. 369 - 375, http://dx.doi.org/10.1016/S1357-2725(98)00123-X
1999
Lyons MA; Samman S; Gatto L; Brown AJ, 1999, 'Rapid hepatic metabolism of 7-Ketocholesterol in vivo: Implications for dietary oxysterols', FASEB JOURNAL, vol. 13, pp. A1378 - A1378, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033400332&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
1999
Gelissen IC; Rye KA; Brown AJ; Dean RT; Jessup W, 1999, 'Oxysterol efflux from macrophage foam cells: The essential role of acceptor phospholipid', Journal of Lipid Research, vol. 40, pp. 1636 - 1646
1999
Alwan CL; Brown AJ; Cooper VA; Samman S, 1999, 'The role of ascorbic acid in the mosaic of coronary heart disease: Lipid metabolism and antioxidant functions', Journal of Clinical Biochemistry and Nutrition, vol. 26, pp. 85 - 98, http://dx.doi.org/10.3164/jcbn.26.85
1999
Brown AJ; Cartland S; Kraemer FB; Dean RT; Jessup W, 1999, 'Oxysterol-regulation of cholesterol esterification and hydrolysis in macrophages', FASEB JOURNAL, vol. 13, pp. A1378 - A1378, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033400334&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
1999
Brown AJ, 1998, 'Paradoxical effects of acute cigarette smoking on plasma antioxidant status in humans', Nutrition Research, vol. 18, pp. 1499 - 1519, http://dx.doi.org/10.1016/S0271-5317(98)00126-2
1998
Fragoso YD; Brown AJ, 1998, 'In vivo metabolism of alpha-tocopherol in lipoproteins and liver: studies on rabbits in response to acute cholesterol loading.', São Paulo medical journal = Revista paulista de medicina, vol. 116, pp. 1753 - 1759, http://dx.doi.org/10.1590/S1516-31801998000400003
1998
Gelissen IC; Hochgrebe T; Wilson MR; Easterbrook-Smith SB; Jessup W; Dean RT; Brown AJ, 1998, 'Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: A potential anti-atherogenic function?', Biochemical Journal, vol. 331, pp. 231 - 237, http://dx.doi.org/10.1042/bj3310231
1998
Brown AJ; Leong SL; Dean RT; Jessup W, 1997, '7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque', Journal of Lipid Research, vol. 38, pp. 1730 - 1745
1997
Samman S; Brown AJ; Beltran C; Singh S, 1997, 'The effect of ascorbic acid on plasma lipids and oxidisability of LDL in male smokers', European Journal of Clinical Nutrition, vol. 51, pp. 472 - 477, http://dx.doi.org/10.1038/sj.ejcn.1600431
1997
Jessup W; Mander EL; Brown AJ; Gelissen IC; Kritharides L; Dean RT, 1997, 'Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells', ATHEROSCLEROSIS, vol. 134, pp. 231 - 232, http://dx.doi.org/10.1016/S0021-9150(97)89233-7
1997
Brown AJ; Dean RT; Jessup W, 1997, 'Free and esterified oxysterols in human atherosclerotic plaque', ATHEROSCLEROSIS, vol. 134, pp. 210 - 210, http://dx.doi.org/10.1016/S0021-9150(97)89083-1
1997
Lyons MA; Samman S; Brown AJ, 1997, '7-Ketocholesterol and cholesterol incorporated into modified lipoprotein have very different kinetics when injected into rats', ATHEROSCLEROSIS, vol. 134, pp. 30 - 30, http://dx.doi.org/10.1016/S0021-9150(97)88247-0
1997
Gelissen IC; Hochgrebe T; Wilson MR; EasterbrookSmith SB; Jessup W; Dean RT; Brown AJ, 1997, 'Apolipoprotein J (clusterin) induces cholesterol export from macrophage foam cells: A potential anti-atherogenic function?', ATHEROSCLEROSIS, vol. 134, pp. 367 - 367, http://dx.doi.org/10.1016/S0021-9150(97)89865-6
1997
Gelissen IC; Rye KA; Brown AJ; Dean RT; Jessup W, 1997, 'Phospholipid association with apo A-I stimulates oxysterol efflux from macrophage foam cells', ATHEROSCLEROSIS, vol. 134, pp. 367 - 367, http://dx.doi.org/10.1016/S0021-9150(97)89865-6
1997
Kritharides L; Kus M; Brown AJ; Jessup W; Dean RT, 1996, 'Hydroxypropyl-β-cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells', Journal of Biological Chemistry, vol. 271, pp. 27450 - 27455, http://dx.doi.org/10.1074/jbc.271.44.27450
1996
Gelissen IG; Brown AJ; Mander EL; Kritharides L; Dean RT; Jessup W, 1996, 'Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol', Journal of Biological Chemistry, vol. 271, pp. 17852 - 17860, http://dx.doi.org/10.1074/jbc.271.30.17852
1996
Brown AJ, 1996, 'Acute effects of smoking cessation on antioxidant status', Journal of Nutritional Biochemistry, vol. 7, pp. 29 - 39, http://dx.doi.org/10.1016/0955-2863(95)00164-6
1996
Brown AJ; Dean RT; Jessup W, 1996, 'Free and esterified oxysterol: Formation during copper-oxidation of low density lipoprotein and uptake by macrophages', Journal of Lipid Research, vol. 37, pp. 320 - 335
1996
Brown AJ, 1996, 'Atherosclerosis: cell biology and lipoproteins.', Current opinion in lipidology, vol. 7, http://dx.doi.org/10.1097/00041433-199610000-00019
1996
Gatto LM; Hallen GK; Brown AJ; Samman S, 1996, 'Ascorbic acid induces a favorable lipoprotein profile in women.', Journal of the American College of Nutrition, vol. 15, pp. 154 - 158, http://dx.doi.org/10.1080/07315724.1996.10718581
1996
Brown AJ, 1995, 'Atherosclerosis: cell biology and lipoproteins.', Current opinion in lipidology, vol. 6
1995
Riemersma RA; Perkins D; Brown AJ; Brown J, 1994, 'Linoleic acid and coronary artery disease.', The American journal of clinical nutrition, vol. 59, pp. 949 - 950, http://dx.doi.org/10.1093/ajcn/59.4.949
1994
Brown AJ; Fragoso YD, 1994, 'Tocopherols and carotenes are differently distributed in subfractions of high-density lipoprotein', Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, vol. 1210, pp. 373 - 376, http://dx.doi.org/10.1016/0005-2760(94)90243-7
1994
Brown AJ, 1992, 'Atherosclerosis: Cell biology and lipoproteins', Current Opinion in Lipidology, vol. 3, http://dx.doi.org/10.1097/00041433-199204000-00018
1992
Brown AJ; Pang E; Roberts DCK, 1991, 'Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption', Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 44, pp. 103 - 106, http://dx.doi.org/10.1016/0952-3278(91)90191-7
1991
Brown AJ; Roberts DCK, 1991, 'The effect of fasting triacylglyceride concentration and apolipoprotein E polymorphism on postprandial lipemia', Arteriosclerosis and Thrombosis, vol. 11, pp. 1737 - 1744, http://dx.doi.org/10.1161/01.atv.11.6.1737
1991
Brown AJ; Roberts DCK, 1991, 'Moderate fish oil intake improves lipemic response to a standard fat meal: A study in 25 healthy men', Arteriosclerosis and Thrombosis, vol. 11, pp. 457 - 466, http://dx.doi.org/10.1161/01.atv.11.3.457
1991
Brown AJ; Roberts DCK, 1991, 'Fish and fish oil intake: Effect on haematological variables related to cardiovascular disease', Thrombosis Research, vol. 64, pp. 169 - 178, http://dx.doi.org/10.1016/0049-3848(91)90116-E
1991
Brown AJ; Pang E; Roberts DCK, 1991, 'Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids: Study design implications', American Journal of Clinical Nutrition, vol. 54, pp. 668 - 673, http://dx.doi.org/10.1093/ajcn/54.4.668
1991
Brown AJ; Roberts DCK, 1990, 'Erythrocyte EPA as a marker for intake of fish and fish oil', European Journal of Clinical Nutrition, vol. 44, pp. 487 - 488
1990
Brown AJ; Roberts DCK; Pritchard JE; Truswell AS, 1990, 'A mixed Australian fish diet and fish-oil supplementation: Impact on the plasma lipid profile of healthy men', American Journal of Clinical Nutrition, vol. 52, pp. 825 - 833, http://dx.doi.org/10.1093/ajcn/52.5.825
1990
Brown AJ; Cherikoff V; Roberts DCK, 1987, 'Fatty acid composition of seeds from the Australian Acacia species', Lipids, vol. 22, pp. 490 - 494, http://dx.doi.org/10.1007/BF02540364
1987
Conference Abstracts
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Jun SY; Brown AJ; Yoon J-Y; Lee J-J; Chua NK; Yang JOK; Min J-S; Jang I; Jeon S-J; Choi M-H; Choi T-I; Kim C-H; Kim N-S, 2019, 'A squalene epoxidase-cholesterolaxis drives colorectal cancer progression and metastatic dissemination', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Atlanta, GA, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.SABCS18-2769
2019
Prabhu A; Luu W; Sharpe L; Brown A, 2015, 'The Interplay between Cholesterol and Vitamin D Biosynthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 29, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361470504115&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Luu W; Zerenturk E; Kristiana I; Sharpe L; Brown A, 2015, 'Signaling Regulates Activity of DHCR24, the Final Enzyme in Cholesterol Synthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 29, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361470504086&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Books
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Gelissen IC; Brown AJ, (ed.), 2017, Cholesterol Homeostasis Methods and Protocols Preface, Methods in Molecular Biology, HUMANA PRESS INC, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000409258000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2017
Book Chapters
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Brown AJ; Sharpe LJ, 2016, 'Cholesterol Synthesis', in Biochemistry of Lipids, Lipoproteins and Membranes: Sixth Edition, pp. 327 - 358, http://dx.doi.org/10.1016/B978-0-444-63438-2.00011-0
2016
Sharpe LJ; Brown AJ, 2015, 'Investigating signaling processes in membrane trafficking.', in Membrane Trafficking, Springer, New York, pp. 81 - 90, http://dx.doi.org/10.1007/978-1-4939-2309-0_6
2015
Sharpe LJ; Du XR; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-Golgi transport', in Sheehan D; Tyther R (ed.), Methods in Molecular Biology, Two Dimensional Electrophoresis Protocols, Humana Press, Inc., United States, pp. 215 - 227
2008
Conference Papers
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Sharpe LJ; Prabhu AV; Luu W; Brown AJ, 2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444003020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2016
Sharpe LJ; Prabhu AV; Luu W; Brown AJ, 2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444006684&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Luu W; Sharpe LJ; Stevenson J; Brown AJ, 2013, 'Signalling and cholesterol metabolism', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Boston, MA, presented at Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Boston, MA, 20 April 2013 - 24 April 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319883503088&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2013
Zerenturk E; Sharpe LJ; Kristiana I; Brown AJ, 2013, 'DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Boston, MA, presented at Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Boston, MA, 20 April 2013 - 24 April 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319883504279&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2013
Stevenson J; Gill S; Kristiana I; Brown AJ, 2011, 'Cholesterol-Dependent Proteasomal Degradation of Squalene Monooxygenase, a Second Control Point in Cholesterol Synthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Washington, DC, presented at Experimental Biology Meeting 2011, Washington, DC, 09 April 2011 - 13 April 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310708404685&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Gill S; Stevenson J; Kristiana I; Brown A, 2011, 'Controlling cholesterol synthesis beyond HMG-CoA reductase', in CHEMISTRY AND PHYSICS OF LIPIDS, ELSEVIER IRELAND LTD, Univ Warsaw, Old Library, Warsaw, POLAND, pp. S6 - S6, presented at 52nd International Conference on the Bioscience of Lipids - Expanding the Horizons of Lipidomics, Univ Warsaw, Old Library, Warsaw, POLAND, 30 August 2011 - 03 September 2011, http://dx.doi.org/10.1016/j.chemphyslip.2011.05.044
2011
Krycer JR; Brown AJ, 2011, 'Crosstalk between the androgen receptor and liver X receptor', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Washington, DC, presented at Experimental Biology Meeting 2011, Washington, DC, 09 April 2011 - 13 April 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310708406728&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Hsieh VW; Gelissen I; Brown AJ; Kim M-J; Kritharides L; Jessup W, 2010, 'Cholesterol-Dependent Posttranslational Control of ABCG1 and ABCA1 Expression', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, San Francisco, CA, pp. E282 - E282, presented at Scientific Sessions on Arteriosclerosis, Thrombosis and Vascular Biology, San Francisco, CA, 08 April 2010 - 10 April 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283234800446&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2010
Gelissen I; Harris M; Rye KA; Quinn CM; Brown AJ; Kockx M; Cartland S; Packianathan M; Kritharides L; Jessup W, 2006, 'ABCA1 and ABCG1 act sequentially to mediate cholesterol export to apoA-I', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Rome, ITALY, pp. 541 - 541, presented at 14th Meeting of the International-Society-of-Atherosclerosis, Rome, ITALY, 18 June 2006 - 22 June 2006, http://dx.doi.org/10.1016/S1567-5688(06)82178-1
2006
Quinn CM; Brown AJ; Kritharides L; Jessup W, 2002, 'The expression and regulation of sterol 27-hydroxylase (cyp27) in human macrophages', in CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, BLACKWELL PUBLISHING ASIA, MELBOURNE, AUSTRALIA, pp. A25 - A25, presented at Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, MELBOURNE, AUSTRALIA, 27 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183582000066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2002
Van Reyk DM; Brown AJ; Hult'en LM; Hart PH; Dean RT; Jessup W, 2002, 'Lipoprotein-delivered oxysterols do not stimulate cytokine production in macrophage foam cells at pathophysiologically relevant levels', in CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, BLACKWELL PUBLISHING ASIA, MELBOURNE, AUSTRALIA, pp. A18 - A18, presented at Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, MELBOURNE, AUSTRALIA, 27 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183582000053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2002
Conference Presentations
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Moon H; Sharpe L; Choi E; Bielefeldt-Ohmann H; Nassar Z; Parat M-O; Francois M; Lee CS; Brown A; Russell P; Inder K; Hill M, 2014, 'Hypercholesterolemia promotes prostate cancer PC-3 metastases in orthotopic xenograft mice', Vol. 74, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), San Diego, CA, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-4950
2014

Biochemistry involving fats (or lipids), especially pertaining to cholesterol.