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Dr Frances Byrne

Senior Lecturer

Bachelor of Biotechnology (Hons), Flinders University, South Australia

PhD, Paediatric Oncology, Children's Cancer Institute, New South Wales

Science

School of Biotech & Biomolecular Science

Professional Awards and Experience

Cancer Institute NSW Career Development Fellow (UNSW) 2022-2024

Associate Fellow (AFHEA) Advance Higher Education 2021

Bridge Industry Fellowship 2021

Cancer Institute NSW Early Career Fellow (UNSW) 2018-2021

Hope Funds for Cancer Research Postdoctoral Fellow (University of Virginia/UNSW) 2014-2017

Postdoctoral Research Associate, University of Virginia (USA) 2012-2014

Anthony Rothe Memorial Trust PhD Scholar, Children’s Cancer Institute (UNSW) 2008-2012

Research Assistant, Children’s Cancer Institute (UNSW) 2005-2008

Methods Development Scientist, GroPep Bioreagents (Adelaide) 2003-2005

Bachelor of Biotechnology (Hons), Flinders University of South Australia 1999-2002

Research

Dr Byrne received her PhD in 2012 for her research investigating the role of cell cytoskeleton protein, stathmin, in neuroblastoma (Byrne et al. 2014, Oncogene). Dr Byrne trained as a postdoc at the University of Virginia (USA) from 2012-2014 where she investigated the relationship between obesity and cancer, particularly liver and endometrial (uterine) cancers (Byrne et al. 2014, Cancer Research). She returned to Australia in 2014 to the School of Biotechnology & Biomolecular Sciences (UNSW) and now leads an independent lab focused on developing novel treatment strategies for obesity-related cancers.

Research Focus 1: Developing new anti-cancer strategies that target metabolism

Dr Byrne is working with Prof Kyle Hoehn (School of BABS, UNSW) to investigate the therapeutic potential mitochondrial uncouplers in liver cancer. She is also collaborating with Prof Naresh Kumar (Chemistry, UNSW) to develop novel small molecules that alter glucose metabolism in cancer cells.

Research Focus 2: Unravelling the links between diet, obesity, and cancer

Cancers of the liver and uterus (endometrium) are strongly linked to diet and obesity. Dr Byrne's lab is investigating how dietary factors (such as fructose) impact liver tumour development and growth. She is also working with collaborators to investigate 'cancer-specific signatures' associated with obesity-related uterine cancer including changes in uterine microbiota (Kaakoush et al. 2022, Cancers), the transcriptome (Tanaka et al. 2022, Int J Mol Sci), circular RNAs (Tanaka et al. 2023, Gene) and the lipidome.

Teaching

Dr Byrne is an Associate Fellow of Advance Higher Education (AFHEA). She lectures in BABS3151 (topic: Cancer Genetics), BIOC3271/3671 (topic: Molecular Approaches to Cancer Cell Biology, Human Cytoskeleton and Disease), BIOC3261 (topic: Cancer Metabolism), and co-convenes BABS2011 (Current Trends in Biotechnology). She lectures and leads practicals in the School of Medicine (MFAC1525: Ageing and Endings). She supervises PhD, Masters, honours, and undergraduate students in the Schools of BABS, Chemistry, and Biomedical Sciences.

Organisational roles

Chair: School of Biotechnology & Biomolecular Sciences Equity, Diversity and Inclusion (EDI) Committee (UNSW) 2022- current

School representative: Faculty of Science EDI working group (SEDIWG) 2022- current

Co-chair: Executive Committee for the Women in Research Network (WiRN) 2022-2023

Engagement with community

Dr Byrne recognizes the importance of communicating her research with research advocates, including Mr Jeff Cuff who sadly lost his wife colon cancer in 2013. Jeff has been an active member of Dr Byrne’s laboratory which led to co-authorship on Dr Byrne’s publication (Byrne et al, 2020 Redox Biology) and he continues to play an important role in guiding her research and helping her establish new collaborations with cancer researchers.

Dr Byrne was interviewed by Leah Hazard, an NHS midwife and best-selling author, for her new book ‘Womb: The Inside Story of Where We All Began’. In this book Dr Byrne highlights her research on the link between disruption of uterine microbiota and uterine cancer.

Engagement with Industry

As a previous participant in the MTP Connect Bridge Program (2020) and prior recipient of a Bridge Industry Fellowship (2021), Dr Byrne now serves as the UNSW representative on the steering committee for the national drug commercialisation training program (Bridge Program).

Contribution to Profession

Dr Byrne reviews fellowship applications (Hope Funds for Cancer Research), NHMRC grants, HDR student theses, and manuscripts for Cancer Research, Molecular Cancer Research, Nature Communications, Gynecologic Oncology, Genes & Diseases, Cellular & Molecular Life Sciences, BMC, Cancers, AJP Endocrinology & Metabolism, etc.

She serves on the Honours Committee for the School of BABS and helps organise and chair sessions at national conferences.

She is an invited Guest Editor for Cancers (special issue: Mitochondrial Uncoupling and Cancer).

Phone

02 9065 1211

E-mail

frances.byrne@unsw.edu.au

Location

UNSW Level 4, D26 Biological Sciences Building Kensington 2052 Australia

Book Chapters | 2012

Ng DCH; Byrne FL, 2012, 'Stathmin and Cancer', in Kavallaris M (ed.), Cytoskeleton and Human Disease, Humana Press
Journal articles | 2024

Beretta M; Dai Y; Olzomer EM; Vancuylenburg CS; Santiago-Rivera JA; Philp AM; Hargett SR; Li K; Shah DP; Chen SY; Alexopoulos SJ; Li C; Harris TE; Lee B; Wathier M; Cermak JM; Tucker SP; Turner N; Bayliss DA; Philp A; Byrne FL; Santos WL; Hoehn KL, 2024, 'Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice', Diabetes, 73, pp. 374 - 384, http://dx.doi.org/10.2337/db23-0233

Journal articles | 2024

Chen SY; Beretta M; Olzomer EM; Alexopoulos SJ; Shah DP; Byrne FL; Salamoun JM; Garcia CJ; Smith GC; Larance M; Philp A; Turner N; Santos WL; Cantley J; Hoehn KL, 2024, 'Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870, http://dx.doi.org/10.1016/j.bbadis.2023.166908

Journal articles | 2024

Chen SY; Telfser AJ; Olzomer EM; Vancuylenberg CS; Zhou M; Beretta M; Li C; Alexopoulos SJ; Turner N; Byrne FL; Santos WL; Hoehn KL, 2024, 'Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice', Clinical Science, 138, pp. 173 - 187, http://dx.doi.org/10.1042/CS20231016

Journal articles | 2024

Hargett S; Lahiri S; Kowalski GM; Corley S; Nelson ME; Lackner C; Olzomer EM; Aleksovska I; Hearn BA; Shrestha R; Janitz M; Gorrell MD; Bruce CR; Wilkins M; Hoehn KL; Byrne FL, 2024, 'Bile acids mediate fructose-associated liver tumour growth in mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870, http://dx.doi.org/10.1016/j.bbadis.2024.167029

Journal articles | 2023

Byrne FL; Bell JL, 2023, 'Neuroblastoma Differentiation: The Untapped Potential of Mitochondrial Uncouplers', Cancer Research, 83, pp. 167 - 169, http://dx.doi.org/10.1158/0008-5472.CAN-22-3350

Journal articles | 2023

Chen SY; Beretta M; Olzomer EM; Shah DP; Wong DYH; Alexopoulos SJ; Aleksovska I; Salamoun JM; Garcia CJ; Cochran BJ; Rye KA; Smith GC; Byrne FL; Morris MJ; Santos WL; Cantley J; Hoehn KL, 2023, 'Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice', Molecular Metabolism, 69, http://dx.doi.org/10.1016/j.molmet.2023.101684

Journal articles | 2023

Coates HW; Capell-Hattam IM; Olzomer EM; Du X; Farrell R; Yang H; Byrne FL; Brown AJ, 2023, 'Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase', eLife, 12, http://dx.doi.org/10.7554/eLife.82843

Journal articles | 2023

Takenaka K; Olzomer EM; Hoehn KL; Curry-Hyde A; Jun Chen B; Farrell R; Byrne FL; Janitz M, 2023, 'Investigation of circular RNA transcriptome in obesity-related endometrial cancer', Gene, 855, http://dx.doi.org/10.1016/j.gene.2022.147125

Journal articles | 2022

Byrne FL; Olzomer EM; Lolies N; Hoehn KL; Wegner MS, 2022, 'Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma', International Journal of Molecular Sciences, 23, http://dx.doi.org/10.3390/ijms23094477

Journal articles | 2022

Chen SY; Olzomer EM; Beretta M; Cantley J; Nunemaker CS; Hoehn KL; Byrne FL, 2022, 'Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity', International Journal of Molecular Sciences, 23, http://dx.doi.org/10.3390/ijms23179798

Journal articles | 2022

Kaakoush NO; Olzomer EM; Kosasih M; Martin AR; Fargah F; Lambie N; Susic D; Hoehn KL; Farrell R; Byrne FL, 2022, 'Differences in the Active Endometrial Microbiota across Body Weight and Cancer in Humans and Mice', Cancers, 14, http://dx.doi.org/10.3390/cancers14092141

Journal articles | 2022

Sumer-Bayraktar Z; Fife CM; Byrne FL; Kavallaris M; Packer NH, 2022, 'Membrane glycome is impacted by the cell culturing mode of neuroblastoma cells with differing migration and invasion potential', Glycobiology, 32, pp. 588 - 599, http://dx.doi.org/10.1093/glycob/cwac016

Journal articles | 2022

Takenaka K; Curry-Hyde A; Olzomer EM; Farrell R; Byrne FL; Janitz M, 2022, 'Investigation of Transcriptome Patterns in Endometrial Cancers from Obese and Lean Women', International Journal of Molecular Sciences, 23, http://dx.doi.org/10.3390/ijms231911471

Journal articles | 2021

Shrestha R; Johnson E; Byrne FL, 2021, 'Exploring the therapeutic potential of mitochondrial uncouplers in cancer', Molecular Metabolism, 51, http://dx.doi.org/10.1016/j.molmet.2021.101222

Journal articles | 2021

Wegner MS; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, 2021, 'Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells', Cellular and Molecular Life Sciences, 78, pp. 7025 - 7041, http://dx.doi.org/10.1007/s00018-021-03958-9

Journal articles | 2020

Alexopoulos SJ; Chen SY; Brandon AE; Salamoun JM; Byrne FL; Garcia CJ; Beretta M; Olzomer EM; Shah DP; Philp AM; Hargett SR; Lawrence RT; Lee B; Sligar J; Carrive P; Tucker SP; Philp A; Lackner C; Turner N; Cooney GJ; Santos WL; Hoehn KL, 2020, 'Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-16298-2

Journal articles | 2020

Byrne FL; Martin AR; Kosasih M; Caruana BT; Farrell R, 2020, 'The role of hyperglycemia in endometrial cancer pathogenesis', Cancers, 12, http://dx.doi.org/10.3390/cancers12051191

Journal articles | 2020

Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF; Cuff J; Martyn GE; Childress E; Alexopoulos SJ; Poon IK; Faux MC; Burgess AW; Reid G; McCarroll JA; Santos WL; Quinlan KG; Turner N; Fazakerley DJ; Kumar N; Hoehn KL, 2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, 28, http://dx.doi.org/10.1016/j.redox.2019.101374

Journal articles | 2020

Caruana BT; Byrne FL, 2020, 'The NF-κB signalling pathway regulates GLUT6 expression in endometrial cancer', Cellular Signalling, 73, http://dx.doi.org/10.1016/j.cellsig.2020.109688

Journal articles | 2020

Flynn MC; Kraakman MJ; Tikellis C; Lee MKS; Hanssen NMJ; Kammoun HL; Pickering RJ; Dragoljevic D; Al-Sharea A; Barrett TJ; Hortle F; Byrne FL; Olzomer E; McCarthy DA; Schalkwijk CG; Forbes JM; Hoehn K; Makowski L; Lancaster GI; El-Osta A; Fisher EA; Goldberg IJ; Cooper ME; Nagareddy PR; Thomas MC; Murphy AJ, 2020, 'Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis', Circulation Research, 127, pp. 877 - 892, http://dx.doi.org/10.1161/CIRCRESAHA.120.316653

Journal articles | 2020

Hegarty KJ; Byrne FL, 2020, 'Comment on “differential effects of mitovite, α-tocopherol and trolox on oxidative stress, mitochondrial function and inflammatory signalling pathways in endothelial cells cultured under conditions mimicking sepsis, antioxidants 2020, 9(3), 195”', Antioxidants, 9, http://dx.doi.org/10.3390/antiox9060462

Journal articles | 2020

Schömel N; Gruber L; Alexopoulos SJ; Trautmann S; Olzomer EM; Byrne FL; Hoehn KL; Gurke R; Thomas D; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-65182-y

Journal articles | 2019

Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, 202, pp. 1826 - 1832, http://dx.doi.org/10.4049/jimmunol.1801063

Journal articles | 2019

Huo Y; Buckton LK; Bennett JL; Smith EC; Byrne FL; Hoehn KL; Rahimi MN; McAlpine SR, 2019, 'Delivering bioactive cyclic peptides that target Hsp90 as prodrugs', Journal of Enzyme Inhibition and Medicinal Chemistry, 34, pp. 728 - 739, http://dx.doi.org/10.1080/14756366.2019.1580276

Journal articles | 2019

Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-52169-7

Journal articles | 2018

Byrne FL; Hargett SR; Lahiri S; Roy RJ; Berr SS; Caldwell SH; Hoehn KL, 2018, 'Serial MRI imaging reveals minimal impact of ketogenic diet on established liver tumor growth', Cancers, 10, http://dx.doi.org/10.3390/cancers10090312

Journal articles | 2018

Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology - Endocrinology and Metabolism, 315, pp. E286 - E293, http://dx.doi.org/10.1152/ajpendo.00082.2018

Journal articles | 2018

Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, 9, pp. 5786 - 5796, http://dx.doi.org/10.18632/oncotarget.23534

Journal articles | 2018

Namivandi-Zangeneh R; Kwan RJ; Nguyen TK; Yeow J; Byrne FL; Oehlers SH; Wong EHH; Boyer C, 2018, 'The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers', Polymer Chemistry, 9, pp. 1735 - 1744, http://dx.doi.org/10.1039/c7py01069a

Journal articles | 2018

Namivandi-Zangeneh R; Kwan RJ; Thuy-Khanh N; Yeow J; Byrne FL; Oehlers SH; Wong EHH; Boyer C, 2018, 'The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers (vol 9, pg 1735, 2017)', POLYMER CHEMISTRY, 9, pp. 1745 - 1745, http://dx.doi.org/10.1039/c7py90140b

Journal articles | 2018

Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', ESMO Open, 3, pp. A25 - A25, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.56

Journal articles | 2017

Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer', Gynecologic Oncology, 147, pp. 654 - 662, http://dx.doi.org/10.1016/j.ygyno.2017.10.006

Journal articles | 2017

Fife CM; Sagnella SM; Teo WS; Po'uha ST; Byrne FL; Yeap YY; Ng DC; Davis TP; McCarroll JA; Kavallaris M, 2017, 'Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.', Oncogene, 36, pp. 501 - 511, http://dx.doi.org/10.1038/onc.2016.220

Journal articles | 2017

Gordon HM; Majithia N; MacDonald PE; Fox JEM; Sharma PR; Byrne FL; Hoehn KL; Evans-Molina C; Langman L; Brayman KL; Nunemaker CS, 2017, 'STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation', Endocrine, 56, pp. 528 - 537, http://dx.doi.org/10.1007/s12020-017-1297-2

Journal articles | 2017

Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, 8, http://dx.doi.org/10.1038/ncomms14689

Journal articles | 2016

Baker W; Paquette C; Byrne FL; Atkins KA; Shupnik M; Modesitt SC; Hoehn KL; Slack-Davis JK, 2016, 'Postmenopausal endometrial cancer patients have significantly higher expression of GLUT6 in the endometrium', Gynecologic Oncology, 141, pp. 175 - 176, http://dx.doi.org/10.1016/j.ygyno.2016.04.456

Journal articles | 2016

Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing', Journal of Pathology, 239, pp. 3 - 5, http://dx.doi.org/10.1002/path.4702

Journal articles | 2016

Byrne FL; McCarroll JA; Kavallaris M, 2016, 'Analyses of tumor burden in vivo and metastasis ex vivo using luciferase-expressing cancer cells in an orthotopic mouse model of neuroblastoma', RNA imaging: methods and protocols, 1372, pp. 61 - 77, http://dx.doi.org/10.1007/978-1-4939-3148-4_5

Journal articles | 2016

Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice', Scientific Reports, 6, http://dx.doi.org/10.1038/srep22292

Journal articles | 2016

McCarroll JA, 2016, 'Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration', Oncogene, http://dx.doi.org/10.1038/onc.2016.220.

Journal articles | 2016

Takenaka K; Chen BJ; Modesitt SC; Byrne FL; Hoehn KL; Janitz M, 2016, 'The emerging role of long non-coding RNAs in endometrial cancer', Cancer Genetics, 209, pp. 445 - 455, http://dx.doi.org/10.1016/j.cancergen.2016.09.005

Journal articles | 2015

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Journal articles | 2015

Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine', Journal of Hepatology, 62, pp. 599 - 606, http://dx.doi.org/10.1016/j.jhep.2014.10.024

Journal articles | 2015

Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth', Molecular Cell, 57, pp. 537 - 551, http://dx.doi.org/10.1016/j.molcel.2015.01.002

Journal articles | 2015

McCarroll JA; Gan PP; Erlich RB; Liu M; Dwarte T; Sagnella SS; Akerfeldt MC; Yang L; Parker AL; Chang MH; Shum MS; Byrne FL; Kavallaris M, 2015, 'TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer', Cancer Research, 75, pp. 415 - 425, http://dx.doi.org/10.1158/0008-5472.CAN-14-2740

Journal articles | 2014

Bupp MG; Litvin S; Edwards R; Mihalcoe B; Byrne F; Hoehn K; Anoff J, 2014, 'The forkhead transcription factor, Foxo1, may coordinate naive CD8+T cell homeostasis with energy availability in mice.', JOURNAL OF IMMUNOLOGY, 192, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209765005135&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Journal articles | 2014

Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer', Cancer Research, 74, pp. 5832 - 5845, http://dx.doi.org/10.1158/0008-5472.CAN-14-0254

Journal articles | 2014

Byrne FL; Yang L; Phillips PA; Hansford LM; Fletcher JI; Ormandy CJ; McCarroll JA; Kavallaris M, 2014, 'RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model', Oncogene, 33, pp. 882 - 890, http://dx.doi.org/10.1038/onc.2013.11

Journal articles | 2014

Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, 3, pp. 419 - 431, http://dx.doi.org/10.1016/j.molmet.2014.02.004

Journal articles | 2014

Kenwood BM; Weaver JL; Bajwa A; Poon IK; Byrne FL; Murrow BA; Calderone JA; Huang L; Divakaruni AS; Tomsig JL; Okabe K; Lo RH; Cameron Coleman G; Columbus L; Yan Z; Saucerman JJ; Smith JS; Holmes JW; Lynch KR; Ravichandran KS; Uchiyama S; Santos WL; Rogers GW; Okusa MD; Bayliss DA; Hoehn KL, 2014, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, 3, pp. 114 - 123, http://dx.doi.org/10.1016/j.molmet.2013.11.005

Journal articles | 2013

Kenwood BM; Weaver JL; Byrne FL; Murrow BA; Tomsig JL; Cameron Coleman G; Yan Z; Lynch KR; Bayliss DA; Hoehn KL; Bajwa A; Huang L; Okusa MD; Poon IK; Ravichandran KS; Divakaruni AS; Saucerman JJ; Smith JS; Holmes JW; Rogers GW; Lo RH; Columbus L; Okabe K; Uchiyama S; Calderone JA; Santos WL, 2013, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2013.11.005

Journal articles | 2011

Gan PP; Mccarroll J; Byrne F; Garner J; Kavallaris M, 2011, 'Specific beta-Tubulin Isotypes Can Functionally Enhance or Diminish Epothilone B Sensitivity in Non-Small Cell Lung Cancer Cells', PLoS One, 6, pp. e21717, http://dx.doi.org/10.1371/journal.pone.0021717

Journal articles | 2010

Abraham G; McCaroll J; Byrne F; Saricilar S; Kavallaris M; Bulmus V, 2010, 'Block Co-polymer Nanoparticles with Degradable Cross-Linked Core and Low-Molecular-Weight PEG Corona for Anti-tumour Drug Delivery', Journal of Biomaterials Science - Polymer Edition, 22, pp. 1001 - 1022, http://dx.doi.org/10.1163/092050610X497872

Journal articles | 2008

Chan YK; Wong TH; Byrne F; Kavallaris M; Bulmus V, 2008, 'Acid-labile core cross-linked micelles for pH-triggered release of antitumor drugs.', Biomacromolecules, 9, pp. 1826 - 1836, http://dx.doi.org/10.1021/bm800043n

Journal articles | 2006

Chan YK; Bulmus V; Zareie MH; Barner L; Kavallaris M; Byrne F, 2006, 'Acid-Cleavable polymeric core-shell particles for delivery of hydrophoblic drugs', Journal of Controlled Release, 115, pp. 197 - 207
Preprints | 2022

Byrne F; Olzomer E; Lolies N; Hoehn KL; Wegner M-S, 2022, Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma, , http://dx.doi.org/10.20944/preprints202203.0309.v1

Preprints | 2022

Coates H; Olzomer E; Du X; Farrell R; Yang H; Byrne F; Brown A, 2022, Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase, , http://dx.doi.org/10.1101/2022.08.18.504470

Preprints | 2021

Wegner M-S; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, 2021, Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells, , http://dx.doi.org/10.21203/rs.3.rs-454533/v1

Conference Papers | 2014

Fife CM; Byrne FL; Sagnella SM; Davis TP; McCarroll JA; Kavallaris M, 2014, 'Stathmin regulates cell migration, invasion and transendothelial migration via RhoA activation in neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-4987

Conference Papers | 2014

McCarroll JA; Gan PP; Erlich RB; Liu M; Dwarte T; Akerfeldt MC; Chang M; Shum MS; Byrne F; Kavallaris M, 2014, 'beta III-tubulin is required for the tumorigenic phenotype and resistance to anoikis via the PTEN/AKT signaling axis in non-small cell lung cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-2076

Conference Abstracts | 2012

Byrne FL; Phillips PA; Hansford LM; Fletcher JI; Ormandy CJ; McCarroll JA; Kavallaris M, 2012, 'Stathmin suppression influences ROCK signaling and reduces cell invasion and metastasis in neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1444

Theses / Dissertations | 2012

Byrne FL, 2012, Investigation of stathmin's role in neuroblastoma drug resistance, differentiation and metastasis, University of New South Wales, Children's Cancer Institute

Conference Papers | 2010

Byrne FL; McCarroll J; Kavallaris M, 2010, 'Abstract 5141: Stathmin mediates neuroblastoma migration and invasion via regulation of the actin network', in Cancer Research, American Association for Cancer Research (AACR), pp. 5141 - 5141, http://dx.doi.org/10.1158/1538-7445.am10-5141

Conference Papers | 2010

McCarroll JA; Gan PP; Liu M; Dwarte T; Chang M; Byrne F; Kavallaris M, 2010, 'beta III-Tubulin regulates expression of proteins involved in tumorigenesis and metastasis in non-small cell lung cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM10-5026

Conference Papers | 2010

McCarroll JA; Gan PP; Liu M; Dwarte T; Chang M; Byrne F; Kavallaris M, 2010, 'beta III-Tubulin regulates expression of proteins involved in tumorigenesis and metastasis in non-small cell lung cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209823904149&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Fellowships/Scholarships/Funding

Seed funding from the Schools of Biomedical Sciences/Biotechnology & Biomolecular Sciences ($20K) (2023)

Tenure Track Support Award (2022)

Cancer Institute NSW Career Development Fellowship (2022-2024)

Researcher Exchange & Development within Industry (REDI) Fellowship (2021)

Cancer Institute NSW Early Career Fellowship (2018-2021)

UNSW Career Advancement Fund (2019)

Translational Cancer Research Network (TCRN) grant (2018)

Next Generation Sequencing Grant, UNSW (2018)

Conference and Professional Development Grant, TCRN (2017)

Early Career Researcher Grant, Faculty of Science, UNSW (2016)

Hope Funds for Cancer Research Postdoctoral Fellowship (2014-2017) (USA), Malcolm AS Moore Honorary Fellow

Anthony Rothe Memorial PhD Scholarship (2008-2011)

Louiza Zervos Memorial Scholarship in Paediatrics (2010)

Bioscience Reports Best EMCR Poster Presentation ($250), NSW Cancer Conference, Sydney NSW (2022)

Paper of the Month for publication in Cancers, School of Biotechnology and Biomolecular Sciences, UNSW (May, 2022)

Paper of the Month for publication in Redox Biology, School of Biotechnology and Biomolecular Sciences, UNSW (November, 2019)

Best oral presentation at AussieMit conference, Harry Perkins Institute of Medical Research, Perth, WA (2014)

Australian Mitochondrial Disease Foundation Travel Grant, AussieMit conference, Perth, WA (2014)

Paper of the Month for publication in Cancer Research, School of Biotechnology and Biomolecular Sciences, UNSW, Australia (2014)

Sydney Catalyst Prize for best cancer-related poster, Annual Garvan Signalling Symposium, Sydney, Australia (2014)

Jefferson Cup awarded for oral presentation at the UVA Postdoctoral Research Day, University of Virginia (USA) (2014)

Poster prize at the Inaugural UVA Postdoctoral Research Day, University of Virginia (USA) (2013)

University of Sydney Medal for Best Overall Presentation, ASMR Medical Research Week NSW Scientific Meeting (2011)

My Research Supervision

UNSW Scientia PhD Students (current)

Riya Shrestha

UNSW School of Chemistry PhD Student

Yao Cheng

UNSW Scientia PhD Students (previous)

Sing-Young Chen

Stephanie Alexopoulos

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