Frances Byrne

Lecturer

Disruptions to normal metabolism, both at cellular and whole-body levels, can lead to diseases such as obesity and cancer. Dr Byrne’s research is focused on developing novel drugs that target the unique metabolism of cancer cells and investigating how obesity contributes to cancer development.

Journal articles
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Alexopoulos SJ; Chen SY; Brandon AE; Salamoun JM; Byrne FL; Garcia CJ; Beretta M; Olzomer EM; Shah DP; Philp AM; Hargett SR; Lawrence RT; Lee B; Sligar J; Carrive P; Tucker SP; Philp A; Lackner C; Turner N; Cooney GJ; Santos WL; Hoehn KL, 2020, 'Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice', Nature Communications, vol. 11, pp. 2397, http://dx.doi.org/10.1038/s41467-020-16298-2
2020
Schömel N; Gruber L; Alexopoulos SJ; Trautmann S; Olzomer EM; Byrne FL; Hoehn KL; Gurke R; Thomas D; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells', Scientific Reports, vol. 10, pp. 8182, http://dx.doi.org/10.1038/s41598-020-65182-y
2020
Byrne FL; Martin AR; Kosasih M; Caruana BT; Farrell R, 2020, 'The role of hyperglycemia in endometrial cancer pathogenesis', Cancers, vol. 12, http://dx.doi.org/10.3390/cancers12051191
2020
Flynn MC; Kraakman MJ; Tikellis C; Lee MK; Hanssen NM; Kammoun HL; Pickering R; Dragoljevic D; Al-Sharea A; Barrett TJ; Hortle F; Byrne FL; Olzomer E; McCarthy DA; Schalkwijk CG; Forbes JM; Hoehn K; Makowski L; Lancaster GI; El-Osta A; Fisher EA; Goldberg IJ; Cooper ME; Nagareddy PR; Thomas MC; Murphy AJ, 2020, 'Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis', Circulation research, http://dx.doi.org/10.1161/CIRCRESAHA.120.316653
2020
Caruana BT; Byrne FL, 2020, 'The NF-κB signalling pathway regulates GLUT6 expression in endometrial cancer', Cellular Signalling, vol. 73, http://dx.doi.org/10.1016/j.cellsig.2020.109688
2020
Hegarty KJ; Byrne FL, 2020, 'Comment on “differential effects of mitovite, α-tocopherol and trolox on oxidative stress, mitochondrial function and inflammatory signalling pathways in endothelial cells cultured under conditions mimicking sepsis, antioxidants 2020, 9(3), 195”', Antioxidants, vol. 9, http://dx.doi.org/10.3390/antiox9060462
2020
Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF; Cuff J; Martyn GE; Childress E; Alexopoulos SJ; Poon IK; Faux MC; Burgess AW; Reid G; McCarroll JA; Santos WL; Quinlan KG; Turner N; Fazakerley DJ; Kumar N; Hoehn KL, 2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, vol. 28, pp. 101374 - 101374, http://dx.doi.org/10.1016/j.redox.2019.101374
2020
Huo Y; Buckton LK; Bennett JL; Smith EC; Byrne FL; Hoehn KL; Rahimi MN; McAlpine SR, 2019, 'Delivering bioactive cyclic peptides that target Hsp90 as prodrugs', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 34, pp. 728 - 739, http://dx.doi.org/10.1080/14756366.2019.1580276
2019
Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, vol. 202, pp. 1826 - 1832, http://dx.doi.org/10.4049/jimmunol.1801063
2019
Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, vol. 9, pp. 15665, http://dx.doi.org/10.1038/s41598-019-52169-7
2019
Namivandi-Zangeneh R; Kwan RJ; Nguyen TK; Yeow J; Byrne FL; Oehlers SH; Wong EHH; Boyer C, 2018, 'The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers', Polymer Chemistry, vol. 9, pp. 1735 - 1744, http://dx.doi.org/10.1039/c7py01069a
2018
Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, vol. 9, pp. 5786 - 5796, http://dx.doi.org/10.18632/oncotarget.23534
2018
Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology - Endocrinology and Metabolism, vol. 315, pp. E286 - E293, http://dx.doi.org/10.1152/ajpendo.00082.2018
2018
Namivandi-Zangeneh R; Kwan RJ; Thuy-Khanh N; Yeow J; Byrne FL; Oehlers SH; Wong EHH; Boyer C, 2018, 'The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers (vol 9, pg 1735, 2017)', POLYMER CHEMISTRY, vol. 9, pp. 1745 - 1745, http://dx.doi.org/10.1039/c7py90140b
2018
Byrne FL; Hargett SR; Lahiri S; Roy RJ; Berr SS; Caldwell SH; Hoehn KL, 2018, 'Serial MRI imaging reveals minimal impact of ketogenic diet on established liver tumor growth', Cancers, vol. 10, http://dx.doi.org/10.3390/cancers10090312
2018
Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer', Gynecologic Oncology, vol. 147, pp. 654 - 662, http://dx.doi.org/10.1016/j.ygyno.2017.10.006
2017
Gordon HM; Majithia N; MacDonald PE; Fox JEM; Sharma PR; Byrne FL; Hoehn KL; Evans-Molina C; Langman L; Brayman KL; Nunemaker CS, 2017, 'STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation', Endocrine, vol. 56, pp. 528 - 537, http://dx.doi.org/10.1007/s12020-017-1297-2
2017
Fife CM; Sagnella SM; Teo WS; Po'uha ST; Byrne FL; Yeap YY; Ng DC; Davis TP; McCarroll JA; Kavallaris M, 2017, 'Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.', Oncogene, vol. 36, pp. 501 - 511, http://dx.doi.org/10.1038/onc.2016.220
2017
Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms14689
2017
McCarroll JA, 2016, 'Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration', Oncogene, vol. 36, pp. 501 - 511, http://dx.doi.org/10.1038/onc.2016.220.
2016
Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing', Journal of Pathology, vol. 239, pp. 3 - 5, http://dx.doi.org/10.1002/path.4702
2016
Takenaka K; Chen BJ; Modesitt SC; Byrne FL; Hoehn KL; Janitz M, 2016, 'The emerging role of long non-coding RNAs in endometrial cancer', Cancer Genetics, vol. 209, pp. 445 - 455, http://dx.doi.org/10.1016/j.cancergen.2016.09.005
2016
Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep22292
2016
Byrne FL; McCarroll JA; Kavallaris M, 2016, 'Analyses of tumor burden in vivo and metastasis ex vivo using luciferase-expressing cancer cells in an orthotopic mouse model of neuroblastoma', RNA imaging: methods and protocols, vol. 1372, pp. 61 - 77, http://dx.doi.org/10.1007/978-1-4939-3148-4_5
2016
Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth', Molecular Cell, vol. 57, pp. 537 - 551, http://dx.doi.org/10.1016/j.molcel.2015.01.002
2015
Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602
2015
McCarroll JA; Gan PP; Erlich RB; Liu M; Dwarte T; Sagnella SS; Akerfeldt MC; Yang L; Parker AL; Chang MH; Shum MS; Byrne FL; Kavallaris M, 2015, 'TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer', Cancer Research, vol. 75, pp. 415 - 425, http://dx.doi.org/10.1158/0008-5472.CAN-14-2740
2015
Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine', Journal of Hepatology, vol. 62, pp. 599 - 606, http://dx.doi.org/10.1016/j.jhep.2014.10.024
2015
Byrne FL; Yang L; Phillips PA; Hansford LM; Fletcher JI; Ormandy CJ; McCarroll JA; Kavallaris M, 2014, 'RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model', Oncogene, vol. 33, pp. 882 - 890, http://dx.doi.org/10.1038/onc.2013.11
2014
Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, vol. 3, pp. 419 - 431, http://dx.doi.org/10.1016/j.molmet.2014.02.004
2014
Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer', Cancer Research, vol. 74, pp. 5832 - 5845, http://dx.doi.org/10.1158/0008-5472.CAN-14-0254
2014
Kenwood BM; Weaver JL; Byrne FL; Murrow BA; Tomsig JL; Cameron Coleman G; Yan Z; Lynch KR; Bayliss DA; Hoehn KL; Bajwa A; Huang L; Okusa MD; Poon IK; Ravichandran KS; Divakaruni AS; Saucerman JJ; Smith JS; Holmes JW; Rogers GW; Lo RH; Columbus L; Okabe K; Uchiyama S; Calderone JA; Santos WL, 2013, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2013.11.005
2013
Gan PP; Mccarroll J; Byrne F; Garner J; Kavallaris M, 2011, 'Specific beta-Tubulin Isotypes Can Functionally Enhance or Diminish Epothilone B Sensitivity in Non-Small Cell Lung Cancer Cells', PLoS One, vol. 6, pp. e21717, http://dx.doi.org/10.1371/journal.pone.0021717
2011
Abraham G; McCaroll J; Byrne F; Saricilar S; Kavallaris M; Bulmus V, 2010, 'Block Co-polymer Nanoparticles with Degradable Cross-Linked Core and Low-Molecular-Weight PEG Corona for Anti-tumour Drug Delivery', Journal of Biomaterials Science - Polymer Edition, vol. 22, pp. 1001 - 1022, http://dx.doi.org/10.1163/092050610X497872
2010
Chan YK; Wong TH; Byrne F; Kavallaris M; Bulmus V, 2008, 'Acid-labile core cross-linked micelles for pH-triggered release of antitumor drugs.', Biomacromolecules, vol. 9, pp. 1826 - 1836, http://dx.doi.org/10.1021/bm800043n
2008
Chan YK; Bulmus V; Zareie MH; Barner L; Kavallaris M; Byrne F, 2006, 'Acid-Cleavable polymeric core-shell particles for delivery of hydrophoblic drugs', Journal of Controlled Release, vol. 115, pp. 197 - 207, http://dx.doi.org/10.1016/j.jconrel.2006.07.025
2006
Conference Papers
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Fife CM; Byrne FL; Sagnella SM; Davis TP; McCarroll JA; Kavallaris M, 2014, 'Stathmin regulates cell migration, invasion and transendothelial migration via RhoA activation in neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, San Diego, CA, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), San Diego, CA, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-4987
2014
McCarroll JA; Gan PP; Erlich RB; Liu M; Dwarte T; Akerfeldt MC; Chang M; Shum MS; Byrne F; Kavallaris M, 2014, 'beta III-tubulin is required for the tumorigenic phenotype and resistance to anoikis via the PTEN/AKT signaling axis in non-small cell lung cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, San Diego, CA, presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), San Diego, CA, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-2076
2014
McCarroll JA; Gan PP; Liu M; Dwarte T; Chang M; Byrne F; Kavallaris M, 2010, 'beta III-Tubulin regulates expression of proteins involved in tumorigenesis and metastasis in non-small cell lung cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM10-5026
2010
Conference Abstracts
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Byrne FL; Phillips PA; Hansford LM; Fletcher JI; Ormandy CJ; McCarroll JA; Kavallaris M, 2012, 'Stathmin suppression influences ROCK signaling and reduces cell invasion and metastasis in neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1444
2012
Book Chapters
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Ng DCH; Byrne FL, 2012, 'Stathmin and Cancer', in Kavallaris M (ed.), Cytoskeleton and Human Disease, Humana Press, http://dx.doi.org/10.1007/978-1-61779-788-0_14
2012
Theses / Dissertations
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Byrne FL, 2012, Investigation of stathmin's role in neuroblastoma drug resistance, differentiation and metastasis, University of New South Wales, Children's Cancer Institute
2012
  • Paper of the Month for publication in Redox Biology, School of Biotechnology and Biomolecular Sciences, UNSW (2019)

  • Best oral presentation at AussieMit conference, Harry Perkins Institute of Medical Research, Perth, WA (2014)

  • Australian Mitochondrial Disease Foundation Travel Grant, AussieMit conference, Perth, WA (2014)

  • Paper of the Month for publication in Cancer Research, School of Biotechnology and Biomolecular Sciences, UNSW, Australia (2014)

  • Sydney Catalyst Prize for best cancer-related poster, Annual Garvan Signalling Symposium, Sydney, Australia (2014)

  • Jefferson Cup awarded for oral presentation at the UVA Postdoctoral Research Day, University of Virginia (USA) (2014)

  • Poster prize at the Inaugural UVA Postdoctoral Research Day, University of Virginia (USA) (2013)

  • University of Sydney Medal for Best Overall Presentation, ASMR Medical Research Week NSW Scientific Meeting (2011)

 

 

 

 

 

 

Fellowships/Scholarships/Funding

Cancer Institute NSW Early Career Fellowship (2018-2021)

UNSW Career Advancement Fund (2019)

Translational Cancer Research Network (TCRN) grant (2018)

Next Generation Sequencing Grant, UNSW (2018)

Conference and Professional Development Grant, TCRN (2017)

Early Career Researcher Grant, Faculty of Science, UNSW (2016)

Hope Funds for Cancer Research Postdoctoral Fellowship (2014-2017) (USA), Malcolm AS Moore Honorary Fellow

Anthony Rothe Memorial PhD Scholarship (2008-2011)

Louiza Zervos Memorial Scholarship in Paediatrics (2010)