H. Robert Yang

Professor

Biography

Education

  • Bachelor of Medicine (1993), Peking University Health Science Centre, Beijing, China
  • PhD (1998), Columbia University, New York, USA

Professional Experience

  • 2014-2019: NHMRC Senior Research Fellow B
  • 2013-current: Professor, School of BABS
  • 2010-2013: Inaugural ARC Future Fellow
  • 2009-2012: Associate Professor, School of BABS
  • 2007-2008: Senior Lecturer, School of BABS, UNSW
  • 1999-2007: Lecturer/Assistant Professor/Associate Professor with tenure, Department of Biochemistry, National University of Singapore
  • 1999 (April-July): Visiting Fellow, Harvard University

Research Program and Contribution

Our long-term research interests focus on two fundamental yet emerging areas in cell and medical biology:

1.  Intracellular cholesterol sorting and transport, and its role in heart and neurodegenerative diseases.
2.  The biogenesis and dynamics of lipid droplets, adipocyte development, obesity and diabetes.

These two areas are closely linked because lipid droplets may play a crucial role in cellular sterol transport, and lipid droplets are a primary storage site for both free and esterified cholesterol.

Cellular sterol trafficking is a difficult subject to study given the lack of effective approaches to label sterols in live cells. However, it is an important cell biological question because sterols are actively sorted and transported in all eukaryotic cells. In addition, human diseases such as atherosclerosis, Alzheimer’s and Niemann Pick C diseases are linked to aberrant sterol transport.

My early work led to the identification of two key enzymes that catalyse sterol esterification, an important homeostatic step for storing excess sterols (Yang et al., Science, 1996). Our laboratory subsequently identified novel molecules and schemes that govern cellular sterol transport (Wang et al., EMBO J, 2005; Du et al, J Cell Biol., 2011; Ghai et al, Nature Communications, 2017; Wang et al., Molecular Cell, 2019). Currently we aim to identify and characterize a number of novel proteins that regulate the delivery of cholesterol from endosomes and the endoplasmic reticulum to the plasma membrane.

Lipid droplets are key cellular organelles that regulate energy storage and metabolism.  We have identified a number of factors that impact the size of lipid droplets (Fei et al, J Cell Biol., 2008; Fei et al, PLoS Genetics, 2011). One such protein, seipin, also plays an important role in human adipocyte development and maintenance (Cui et al., Human Mol Gen., 2011; Liu et al, Diabetes, 2014; Pagac et al, Cell Reports, 2016; Yan et al, Developmental Cell, 2018). Currently, we aim to understand how lipid droplets are formed from the ER and the exact role of seipin in this process.

Honours and Awards

  • UNSW Dean Of Science Research Excellence Award (2019)
  • NHMRC Senior Research Fellowship B (2014-2019)
  • Inaugural ARC Future Fellowship (2010-2014)
  • Yong Loo Lin School of Medicine Research Excellence Young Scientist Award (2006)
  • Finalist, Singapore National Young Scientist Award (2005)
  • National University of Singapore (NUS) Technopreneurship 21 Award (2004)
  • National University of Singapore (NUS) Young Scientist Award (2002)
  • Member of Editorial Board, BBA Molecular Cell Lipids
  • Editorial Advisor, Biochemical Journal

Selected Publications

QianH., Wu X., Du X., Yao X., Zhao X., Lee J., Yang H*, and Yan N*. (2020) Structural basis of low pH-dependent lysosomal cholesterol egress by NPC1 and NPC2. CELL, 182: 1-14. * Co-corresponding authors.

Qian H., Zhao X., Yan R., Gao S., Sun X., Du X., Yang H., Wong CCL. and Yan N. (2020) Structural basis for catalysis and substrate specificity of human ACAT1. NATURE, 581: 333-338.

Gao M., Liu L., Wang X., Mak H.Y., Liu G. and Yang H. (2020) GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Human Molecular Genetics. 1; 29: 432-443.

Du X., Zhou L., Aw Y.C., Mak H.Y., Xu Y., Rae J., Wang W., Zadoorian A., Hancock S.E., Osborne B., Chen X., Wu J.W., Turner N., Parton R.G., Li P. and Yang H. (2020) ORP5 Localizes to ER-Lipid Droplet Contacts and Regulates the Level of PI(4)P on Lipid Droplets. Journal of Cell Biology, 219, 1-16. Highlighted by JCB

Luo J., Yang H. and Song B.L. (2020) Mechanisms and Regulation of Cholesterol Homeostasis. Nature Reviews Molecular Cell Biology. 21(4): 225-245. 

Xu Y., Du X., Turner N., Brown AJ and Yang H. (2019) Enhanced acyl-CoA: cholesterol acyltransferase activity increases cholesterol levels on lipid droplet surface and impairs adipocyte function. Journal of Biological Chemistry, 294: 19306-19321.

Xu Y., Mak H.Y., Lukmantara I., Li Y.E., Hoehn K.L., Huang X., Du X. and Yang H. (2019) CDP-DAG Synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. Journal of Biological Chemistry, 294, 1-16; doi:10.1074/jbc.RA119.009992

Gao M., Huang X., Song B.L. and Yang H. (2019) The biogenesis of lipid droplets: lipids take center stage. Progress in Lipid Research, 75: 100989. published online July 24th.

Wang H., Ma, Q., Qi, Y., Dong, J., Du, X., Rae, J., Brown A.J., Parton R.G., Wu J.W. and Yang H. (2019) ORP2 delivers cholesterol to the plasma membrane in exchange for phosphatidylinositol 4, 5-bisphosphate (PI(4,5)P2). Molecular Cell, 73, 1–16. Cover Story. Highlighted by Nature Reviews

Dong J., Du X., Wang H., Wang J., Lu C., Chen X., Zhu Z., Luo Z., Yu L., Brown A.J., Yang H* and Wu JW*. (2019) Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nature Communications, 10: 829. * co-corresponding authors. 

Gao M. and Yang H. (2018) VPS13: A lipid transfer protein making contacts at multiple cellular locations.  Journal of Cell Biology, 217: 3322-3324.  

Yan R., Qian H., Lukmantara I., Gao M., Du, X., Yan N. and Yang H. (2018) Human SEIPIN Binds Anionic Phospholipids. Developmental Cell, 47, 1–9. Highlighted by F1000Prime

Du X, Zadoorian A, Lukmantara I, Qi Y, Brown AJ & Yang H. (2018) Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling. Journal of Biological Chemistry, 293: 3806-3818.

Du X, Turner N & Yang H. (2018) The role of oxysterol binding proteins in cancer. Seminars in Cell and Developmental Biology, 81: 149-153.

Ghai R, Du X, Wang H, Dong J, Ferguson C, Brown AJ, Parton RG, Wu JW & Yang H. (2017)  ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P2) and regulate its level at the plasma membrane. Nature Communications, 8:757. Highlighted by F1000Prime

Qi Y, Kapterian TS, Du X, Ma Q, Fei W, Zhang Y, Huang X, Dawes IW & Yang H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57:767-80.

Pagac M, Cooper DE, Qi Y, Lukmantara IE, Mak HY, Wu Z, Tian Y, Liu Z, Lei M, Du X, Ferguson C, Kotevski D, Sadowski P, Chen W, Boroda S, Harris TE, Liu G, Parton RG, Huang X, Coleman RA & Yang H. (2016) SEIPIN regulates lipid droplet expansion and adipocyte development through modulating the activity of glycerol-3-phosphate acyltransferase. Cell Reports, 17: 1546–1559.

Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL & Song BL. (2015) Cholesterol transport through a lysosome-peroxisome membrane contact. CELL, 161: 291-306.

Du X, Brown AJ & Yang H. (2015). Novel mechanisms of intracellular cholesterol transport: membrane contact sites and oxysterol binding proteins. Current Opinion in Cell Biology, 35; 37-42.

Liu L, Jiang QQ, Wang, X, Zhang Y, Lin RC, Lan S, Shui, G, Zhou L, Li P, Wang Y, Cui X, Gao MM, Zhang L, Lv Y, Xu G, Liu G, Zhao D & Yang H. (2014) Adipose-specific knockout of seipin/BSCL2 results in progressive lipodystrophy. Diabetes, 63:1–12 doi 10.2337/db13-0729

Du X, Kazim AS, Dawes IW, Brown AJ & Yang H. (2013) The AAA ATPase VPS4/SKD1 Regulates Endosomal Cholesterol Trafficking Independently of ESCRT-III. Traffic, 14: 107-19.

Yang H*, Galea A, Sytnyk V & Crossley M. (2012) Controlling the size of lipid droplets: protein and lipid factors. Current Opinion in Cell Biology, 24:509-16. (* corresponding author)

Cui X, Wang Y, Meng L, Fei W, Deng J, Xu G, Peng X, Ju S, Liu G, Zhao L & Yang H. (2012) Overexpression of a short isoform of human seipin/BSCL2 in mouse adipose tissue results in mild lipodystrophy. Am J Physiol Endocrinol Metab, 302: E705-13.

Du X, Kazim A, Brown AJ & Yang H. (2012) An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Cell Reports, 1: 29-35. (Inaugural Issue)

Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC & Yang H. (2011) 
A role for phosphatidic acid in the formation of “supersized” lipid droplets. PLoS Genetics, 7: e1002201. Highlighted by F1000Prime

Cui X, Wang Y, Tang Y, Liu Y, Zhao L, Deng J, Xu G, Peng X, Ju S, Liu, G & Yang H. (2011) Seipin ablation in mice results in severe generalized lipodystrophy. Human Molecular Genetics, 20: 3022-30

Fei W, Du X & Yang H. (2011) Seipin, adipogenesis and lipid droplets. Trends in Endocrinology and Metabolism, 22: 204-10.

Du X, Kumar J, Ferguson C, Schulz TA, Ong YS, Hong W, Prinz WA, Parton RG, Brown AJ & Yang H. (2011) A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. Journal of Cell Biology, 192: 121-135.

Fei W, Wang H, Fu X, Bielby C & Yang H. (2009) Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiaeBiochemical Journal 424:61-7.

Low CP, Shui GH, Liew LP, Buttner S, Madeo F, Dawes IW, Wenk MR & Yang H. (2008) Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast. Journal of Cell Science, 121:  2671-2684. Editorial highlight by JCS

Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG & Yang H. (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. Journal of Cell Biology, 180: 473-482. Highlighted by BioCentury Science Business Xchange

Yang H. (2006) Nonvesicular sterol transport: two protein families and a sterol sensor? Trends Cell Biol. 16: 427-32. Epub 2006 Jul 28.

Wang P, Zhang Y, Li H, Chieu HK, Munn AL & Yang H. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and cellular sterol metabolism. EMBO Journal, 24: 2989-99

Zhang Q, Chieu HK, Low CP, Zhang S, Heng CK & Yang H. (2003) Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. Journal of Biological Chemistry, 278: 47145-55

Yang H, Bard M, Bruner DA, Gleeson A, Deckelbaum RJ, Aljinovic G, Pohl T, Rothstein R & Sturley SL. (1996) Sterol Esterification in Yeast: A two gene process. Science, 272, 1353-1356.

 

Journal articles
add
Luo J; Yang H; Song BL, 2020, 'Mechanisms and regulation of cholesterol homeostasis', Nature Reviews Molecular Cell Biology, vol. 21, pp. 225 - 245, http://dx.doi.org/10.1038/s41580-019-0190-7
2020
Gao M; Liu L; Wang X; Mak HY; Liu G; Yang H, 2020, 'GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy', Human Molecular Genetics, vol. 29, pp. 432 - 443, http://dx.doi.org/10.1093/hmg/ddz300
2020
Dou YQ; Kong P; Li CL; Sun HX; Li WW; Yu Y; Nie L; Zhao LL; Miao SB; Li XK; Dong C; Zhang JW; Liu Y; Huo XX; Chi K; Gao X; Zhang N; Weng L; Yang H; Zhang F; Han M, 2020, 'Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia', Theranostics, vol. 10, pp. 1197 - 1212, http://dx.doi.org/10.7150/thno.39320
2020
Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, vol. 581, pp. 333 - 338, http://dx.doi.org/10.1038/s41586-020-2290-0
2020
Zhao M; Zhao L; Xiong X; He Y; Huang W; Liu Z; Ji L; Pan B; Guo X; Wang L; Cheng S; Xu M; Yang H; Yin Y; Garcia-Barrio MT; Chen YE; Meng X; Zheng L, 2020, 'TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice', Gastroenterology, vol. 158, pp. 2266 - 2281.e27, http://dx.doi.org/10.1053/j.gastro.2020.02.033
2020
Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell
2020
Gao M; Yang C; Wang X; Guo M; Yang L; Gao S; Zhang X; Ruan G; Li X; Tian W; Lu G; Dong X; Ma S; Li W; Wang Y; Zhu H; He J; Yang H; Liu G; Xian X, 2020, 'ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death', Metabolism: Clinical and Experimental, vol. 109, pp. 154296, http://dx.doi.org/10.1016/j.metabol.2020.154296
2020
Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, vol. 219, http://dx.doi.org/10.1083/jcb.201905162
2020
Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Gao M; Liao J, 2020, 'Erratum: Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet (Scientific reports (2019) 9 1 (17848))', Scientific reports, vol. 10, pp. 2181, http://dx.doi.org/10.1038/s41598-020-58201-5
2020
Luo J; Jiang LY; Yang H; Song BL, 2019, 'Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites', Trends in Biochemical Sciences, vol. 44, pp. 273 - 292, http://dx.doi.org/10.1016/j.tibs.2018.10.001
2019
Gao G; Sheng Y; Yang H; Chua BT; Xu L, 2019, 'DFCP1 associates with lipid droplets', Cell Biology International, vol. 43, pp. 1492 - 1504, http://dx.doi.org/10.1002/cbin.11199
2019
Lv X; Liu J; Qin Y; Liu Y; Jin M; Dai J; Chua BT; Yang H; Li P, 2019, 'Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1864, pp. 113 - 127, http://dx.doi.org/10.1016/j.bbalip.2018.11.001
2019
Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, vol. 10, pp. 829, http://dx.doi.org/10.1038/s41467-019-08791-0
2019
Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, vol. 294, pp. 19306 - 19321, http://dx.doi.org/10.1074/jbc.RA119.011160
2019
Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, vol. 294, pp. 16740 - 16755, http://dx.doi.org/10.1074/jbc.RA119.009992
2019
Gao M; Huang X; Song BL; Yang H, 2019, 'The biogenesis of lipid droplets: Lipids take center stage', Progress in Lipid Research, vol. 75, http://dx.doi.org/10.1016/j.plipres.2019.100989
2019
Yang H, 2019, 'Extended synaptotagmins, peroxisome-endoplasmic reticulum contact and cholesterol transport', Science China Life Sciences, vol. 62, pp. 1266 - 1269, http://dx.doi.org/10.1007/s11427-019-9573-9
2019
Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, vol. 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014
2019
Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Liao J; Gao M, 2019, 'Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR−/− mice fed on high-fat diet', Scientific Reports, vol. 9, pp. 17848, http://dx.doi.org/10.1038/s41598-019-54392-8
2019
Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, vol. 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558
2018
Du X; Turner N; Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, vol. 81, pp. 149 - 153, http://dx.doi.org/10.1016/j.semcdb.2017.07.017
2018
Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 2018, 'Human SEIPIN Binds Anionic Phospholipids', Dev. Cell, vol. 47, pp. 248 - 256, http://dx.doi.org/10.1016/j.devcel.2018.09.010
2018
Gao M; Yang H, 2018, 'VPs13: A lipid transfer protein making contacts at multiple cellular locations', Journal of Cell Biology, vol. 217, pp. 3322 - 3324, http://dx.doi.org/10.1083/JCB.201808151
2018
Xu D; Li Y; Wu L; Li Y; Zhao D; Yu J; Huang T; Ferguson C; Parton RG; Yang H; Li P, 2018, 'Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions', Journal of Cell Biology, vol. 217, pp. 975 - 995, http://dx.doi.org/10.1083/jcb.201704184
2018
Luo J; Jiang L; Yang H; Song BL, 2017, 'Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends', Traffic, vol. 18, pp. 209 - 217, http://dx.doi.org/10.1111/tra.12471
2017
Reid DW; Xu D; Chen P; Yang H; Sun L, 2017, 'Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-06077-3
2017
Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00861-5
2017
Bai Z; Chai XR; Yoon MJ; Kim HJ; Lo KA; Zhang ZC; Xu D; Siang DTC; Walet ACE; Xu SH; Chia SY; Chen P; Yang H; Ghosh S; Sun L, 2017, 'Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators', PLoS Biology, vol. 15, http://dx.doi.org/10.1371/journal.pbio.2002176
2017
Qi Y; Sun L; Yang H, 2017, 'Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1862, pp. 1273 - 1283, http://dx.doi.org/10.1016/j.bbalip.2017.06.016
2017
Du X; Lukmantara I; Yang H, 2017, 'CRISPR/Cas9-mediated generation of niemann–pick C1 knockout cell line', Methods in Molecular Biology, vol. 1583, pp. 73 - 83, http://dx.doi.org/10.1007/978-1-4939-6875-6_7
2017
Liu X; Xie B; Qi Y; Du X; Wang S; Zhang Y; Paxinos G; Yang H; Liang H, 2016, 'The expression of SEIPIN in the mouse central nervous system', Brain Structure and Function, vol. 221, pp. 4111 - 4127, http://dx.doi.org/10.1007/s00429-015-1151-3
2016
Pagac M; Cooper DE; Qi Y; Lukmantara IE; Mak HY; Wu Z; Tian Y; Liu Z; Lei M; Du X; Ferguson C; Kotevski D; Sadowski P; Chen W; Boroda S; Harris TE; Liu G; Parton RG; Huang X; Coleman RA; Yang H, 2016, 'SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase', Cell Reports, vol. 17, pp. 1546 - 1559, http://dx.doi.org/10.1016/j.celrep.2016.10.037
2016
Wang M; Gao M; Liao J; Qi Y; Du X; Wang Y; Li L; Liu G; Yang H, 2016, 'Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, pp. 410 - 418, http://dx.doi.org/10.1016/j.bbalip.2016.02.018
2016
Qi Y; Kapterian TS; Du X; Ma Q; Fei W; Zhang Y; Huang X; Dawes IW; Yang H, 2016, 'CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development', Journal of Lipid Research, vol. 57, pp. 767 - 780, http://dx.doi.org/10.1194/jlr.M060574
2016
Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites', Current Opinion in Cell Biology, vol. 35, pp. 37 - 42, http://dx.doi.org/10.1016/j.ceb.2015.04.002
2015
Zhou L; Park SY; Xu L; Xia X; Ye J; Su L; Jeong KH; Hur JH; Oh H; Tamori Y; Zingaretti CM; Cinti S; Argente J; Yu M; Wu L; Ju S; Guan F; Yang H; Choi CS; Savage DB; Li P, 2015, 'Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms6949
2015
Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602
2015
He X; Leow KY; Yang H; Heng CK, 2015, 'Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A: Cholesterol acyltransferase 2', Gene, vol. 566, pp. 236 - 241, http://dx.doi.org/10.1016/j.gene.2015.04.061
2015
Chu B-B; Liao Y-C; Qi W; Xie C; Du X; Wang J; Yang H; Miao H-H; Li B-L; Song B-L, 2015, 'Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts', Cell, vol. 161, pp. 291 - 306, http://dx.doi.org/10.1016/j.cell.2015.02.019
2015
Liu L; Jiang Q; Wang X; Zhang Y; Lin RCY; Lam SM; Shui G; Zhou L; Li P; Wang Y; Cui X; Gao M; Zhang L; Lv Y; Xu G; Liu G; Zhao D; Yang H, 2014, 'Adipose-specific knockout of Seipin/Bscl2 results in progressive lipodystrophy', Diabetes, vol. 63, pp. 2320 - 2331, http://dx.doi.org/10.2337/db13-0729
2014
Jiang M; Gao M; Wu C; He H; Guo X; Zhou Z; Yang H; Xiao X; Liu G; Sha J, 2014, 'Lack of testicular seipin causes teratozoospermia syndrome in men', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. 7054 - 7059, http://dx.doi.org/10.1073/pnas.1324025111
2014
Sun Z; Gong J; Wu H; Xu W; Wu L; Xu D; Gao J; Wu JW; Yang H; Yang M; Li P, 2014, 'Erratum: Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes (Nature Communications (2013) 4 (1594) 10.1038/ncomms2581))', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms5985
2014
Wu L; Xu D; Zhou L; Xie B; Yu L; Yang H; Huang L; Ye J; Deng H; Yuan YA; Chen S; Li P, 2014, 'Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth', Developmental Cell, vol. 30, pp. 378 - 393, http://dx.doi.org/10.1016/j.devcel.2014.07.005
2014
Yang H; Li P; Gong J; Sun Z, 2013, 'Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.', Nature communications, vol. 4, pp. 1594, http://dx.doi.org/10.1038/ncomms2581
2013
Tong J; Yang H; Yang H; Eom SH; Im YJ, 2013, 'Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins', Structure, vol. 21, pp. 1203 - 1213, http://dx.doi.org/10.1016/j.str.2013.05.007
2013
Lu Y; Tayebi N; Li H; Saha N; Yang H; Heng CK, 2013, 'Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population', Lipids in Health and Disease, vol. 12, http://dx.doi.org/10.1186/1476-511X-12-85
2013
Aung-Htut MT; Lam YT; Lim YL; Rinnerthaler M; Gelling CL; Breitenbach M; Yang H; Dawes IW, 2013, 'Maintenance of mitochondrial morphology by autophagy and its role in high glucose effects on chronological lifespan of Saccharomyces cerevisiae', Oxidative Medicine and Cellular Longevity, vol. 2013, pp. 1 - 13, http://dx.doi.org/10.1155/2013/636287
2013
Du X; Yang H, 2013, 'Endosomal cholesterol trafficking: protein factors at a glance.', ACTA Biochimica et Biophysica Sinica, vol. 45, pp. 11 - 17, http://dx.doi.org/10.1093/abbs/gms095&#65279
2013
Du X; Kazim AS; Dawes IW; Brown AJ; Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, vol. 14, pp. 107 - 119, http://dx.doi.org/10.1111/tra.12015
2013
Yang H; Fei W, 2012, 'Genome-wide screens for gene products regulating lipid droplet dynamics', Methods in Cell Biology, vol. 108, pp. 303 - 316, http://dx.doi.org/10.1016/B978-0-12-386487-1.00014-6
2012
Yang H; Sytnyk V; Crossley M; Galea AM, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, vol. 24, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012
2012
Cui X; Wang Y; Meng L; Fei W; Deng J; Xu G; Peng X; Ju SH; Zhang L; Liu G; Zhao L; Yang H, 2012, 'Overexpression of a short human seipin/bscl2 isoform in mouse adipose tissue results in mild lipodystrophy', American Journal of Physiology - Endocrinology and Metabolism, vol. 302, pp. 705 - 713, http://dx.doi.org/10.1152/ajpendo.00237.2011
2012
Yang H; Liu P; Ding Y, 2012, 'Identification of the major functional proteins of prokaryotic lipid droplets', Journal of Lipid Research, vol. 53, pp. 399 - 411, http://dx.doi.org/10.1194/jlr.M021899
2012
Ta MT; Kapterian T; Fei W; Du X; Brown AJ; Dawes IW; Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS Journal, vol. 279, pp. 4231 - 4244, http://dx.doi.org/10.1111/febs.12015
2012
Tian N; Leshchyns'ka I; Welch J; Diakowski W; Yang H; Schachner M; Sytnyk V, 2012, 'Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis.', The Journal of Biological Chemistry, vol. 287, pp. 44447 - 44463, http://dx.doi.org/10.1074/jbc.M112.394973
2012
Du X; Kazim A; Brown AJ; Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking', Cell Reports, vol. 1, pp. 29 - 35, http://dx.doi.org/10.1016/j.celrep.2011.10.004
2012
tian Y; Bi J; Shui G; Wenk M; Yang H; Huang X, 2011, 'Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation', PLOS Genetics, vol. 7, pp. e1001364, http://dx.doi.org/10.1371/journal.pgen.1001364
2011
Fei W; Du XR; Yang H, 2011, 'Seipin, adipogenesis and lipid droplets.', Trends in Endocrinology and Metabolism, vol. 22, pp. 204 - 210, http://dx.doi.org/10.1016/j.tem.2011.02.004
2011
Fei W; Zhong L; Ta T; Yang H, 2011, 'The size and phospholipid composition of lipid droplets can influence their proteome', Biochemical and Biophysical Research Communications, vol. 415, pp. 455 - 462, http://dx.doi.org/10.1016/j.bbrc.2011.10.091
2011
Fei W; Li H; Shui G; Kapterian TS; Bielby C; Du X; Brown AJ; Li P; Wenk M; Liu P; Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', Journal of Lipid Research, vol. 52, pp. 2136 - 2147, http://dx.doi.org/10.1194/jlr.M017566
2011
Lam YT; Aung MT; Lim YL; Yang H; Dawes IW, 2011, 'Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells', Free Radical Biology and Medicine, vol. 50, pp. 963 - 970, http://dx.doi.org/10.1016/j.freeradbiomed.2011.01.013
2011
Du X; Yang H, 2011, 'Sterol-binding proteins and endosomal cholesterol transport', Frontiers in Biology, vol. 6, pp. 190 - 196
2011
Du XR; Kumar J; Ferguson C; Schulz TA; Ong YS; Hong W; Prinz WA; Parton RG; Brown AJ; Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking', Journal of Cell Biology, vol. 192, pp. 121 - 135, http://dx.doi.org/10.1083/jcb.201004142
2011
Yang H; Parton RG; Li P; Shui G; Gong J, 2011, 'Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites', Journal of Cell Biology, vol. 195, pp. 953 - 963, http://dx.doi.org/10.1083/jcb.201104142
2011
Fei W; Shui G; Zhang Y; Krahmer N; Ferguson C; Kapterian T; Lin RCY; Dawes IW; Brown AJ; Li P; Huang X; Parton R; Wenk M; Walther TC; Yang H, 2011, 'A role for phosphatidic acid in the formation of “supersized” lipid droplets', PLOS Genetics, vol. 7, pp. e1002201 1 - e1002201 11, http://dx.doi.org/10.1371/journal.pgen.1002201
2011
Cui X; Wang Y; Tang Y; Liu G; Yang H; Liu Y; Zhao L; Deng J; Xu G; Peng X; Ju SH, 2011, 'Seipin ablation in mice results in severe generalized lipodystrophy', Human Molecular Genetics, vol. 20, pp. 3022 - 3030, http://dx.doi.org/10.1093/hmg/ddr205
2011
Shui G; Guan XL; Gopalakrishnan P; Xue Y; Goh JSY; Yang H; Wenk MR, 2010, 'Characterization of substrate preference for Slc1p and Cst26p in saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay', PLoS ONE, vol. 5, http://dx.doi.org/10.1371/journal.pone.0011956
2010
Yang H, 2010, 'Toward one step analysis of cellular lipidomes using liquid', Molecular Biosystems, vol. 6, pp. 1008 - 1017, http://dx.doi.org/10.1039/b913353d
2010
Shui G; Guan XL; Gopalakrishnan P; Xue Y; Goh JSY; Yang H; Wenk MR, 2010, 'Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay', PLoS One, vol. 4, pp. 11956, http://www.ncbi.nlm.nih.gov/pubmed/20694142
2010
Fei W; Wang H; Fu X; Christopher B; Yang H, 2009, 'Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in saccharomyces cerevisiae', Biochemical Journal, vol. 424, pp. 61 - 67, http://dx.doi.org/10.1042/BJ20090785
2009
Low C; Shui G; Liew L; Buttner S; Madeo F; Dawes IW; Wenk M; Yang H, 2008, 'Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast', Journal of Cell Science, vol. 121, pp. 2671 - 2684, http://dx.doi.org/10.1242/jcs.028977
2008
Low C; Yang H, 2008, 'Programmed cell death in fission yeast Schizosaccharomyces pombe', Biochimica et Biophysica ACTA - Molecular Cell Research, vol. 1783, pp. 1335 - 1349, http://dx.doi.org/10.1016/j.bbamcr.2008.02.002
2008
Kristiana I; Yang H; Brown AJ, 2008, 'Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: Implications for cholesterol trafficking to the endoplasmic reticulum', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, vol. 1781, pp. 724 - 730, http://dx.doi.org/10.1016/j.bbalip.2008.08.006
2008
Toh SK; Gong J; Du GG; Li J; Yang S; Ye JM; Yao H; Zhang Y; Xue B; Li Q; Yang H; Wen Z; Li P, 2008, 'Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of Fsp27 deficient mice', PLoS One, vol. 3, pp. 2890 - 2891, http://dx.doi.org/10.1371/journal.pone.0002890
2008
Fei W; Shui G; Gaeta BA; Du XR; Kuerschner L; Liu P; Brown AJ; Wenk M; Parton R; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast', Journal of Cell Biology, vol. 180, pp. 473 - 482, http://dx.doi.org/10.1083/icb.200711136
2008
Fei W; Alfaro G; Muthusamy B; Klaassen Z; Graham T; Yang H; Beh C, 2008, 'Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae', Eukaryotic Cell, vol. 7, pp. 401 - 414, http://dx.doi.org/10.1128/EC.00386-07
2008
Yang H, 2006, 'Nonvesicular sterol transport: two protein families and a sterol sensor?', Trends in Cell Biology, vol. 16, pp. 427 - 432, http://dx.doi.org/10.1016/j.tcb.2006.07.002
2006
Chen X; Hu ZP; Yang XX; Huang M; Gao Y; Tang W; Chan SY; Dai X; Ye J; Ho PCL; Duan W; Yang HY; Zhu YZ; Zhou SF, 2006, 'Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer', International Immunopharmacology, vol. 6, pp. 499 - 508, http://dx.doi.org/10.1016/j.intimp.2005.08.026
2006
Tian Q; Zhang J; Chan SY; Tan T; Duan W; Huang M; Zhu Y; Chan E; Yu Q; Nie YQ; Ho P; Li Q; Ng K; Yang H; Wei HE; Bian JS; Zhou S, 2006, 'Topotecan is a substrate for multidrug resistance associated protein 4', Current Drug Metabolism, vol. 7, pp. 105 - 118, http://dx.doi.org/10.2174/138920006774832550
2006
Zhang J; Huang M; Guan S; Bi HC; Pan Y; Duan W; Chan SY; Chen X; Hong YH; Bian JS; Yang H; Zhou S, 2006, 'A mechanistic study of the intestinal absorption of Cryptotanshinone, the major active constituent of Salvia miltiorrhiza', Journal of Pharmacology and Experimental Therapeutics, vol. 317, pp. 1285 - 1294, http://dx.doi.org/10.1124/jpet.105.100701
2006
He X; Lu Y; Saha N; Yang H; Heng CK, 2005, 'Acyl-CoA: Cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks', Human Genetics, vol. 118, pp. 393 - 403, http://dx.doi.org/10.1007/s00439-005-0055-3
2005
Tian Q; Zhang J; Tan TMC; Chan E; Duan W; Chan SY; Boelsterli UA; Ho PC-L; Yang H; Bian J-S; Huang M; Zhu Y-Z; Xiong W; Li X; Zhou S, 2005, 'Human multidrug resistance associated protein 4 confers resistance to camptothecins.', Pharm Res, vol. 22, pp. 1837 - 1853, http://dx.doi.org/10.1007/s11095-005-7595-z
2005
Wang P; Duan W; Munn AL; Yang H, 2005, 'Molecular characterization of Oshop, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae', FEBS Journal, vol. 272, pp. 4703 - 4715, http://dx.doi.org/10.1111/j.1742-4658.2005.04886.x
2005
Tian Q; Zhang J; Tan T; Chan E; Duan W; Chan S; Boelsterli UA; Ho P; Yang H; Bian JS; Huang M; Zhu Y; Xiong W; Li XR; Zhou S, 2005, 'Human multidrug resistance associated protein 4 confers resistance to camptothecins', Pharmaceutical Research, vol. 22, pp. 1837 - 1853, http://dx.doi.org/10.1007/s11095-005-7595-z
2005
Lim G; Zhu Y; Wang C; Tan B; Armstrong J; Dokland T; Yang H; Zhu YZ, 2005, 'The last five amino acid residues at the C-terminus of PRK1/PKN are essential for full lipid responsiveness', Cellular Signalling, vol. 17, pp. 1084 - 1097, http://dx.doi.org/10.1016/j.cellsig.2004.12.003
2005
Hu Z; Yang XQ; Ho P; Chan E; Chan S; Xu C; Li XR; Zhu YZ; Duan W; Chen X; Huang M; Yang H; Zhou S, 2005, 'St John`s Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats', Pharmaceutical Research, vol. 22, pp. 902 - 914, http://dx.doi.org/10.1007/s11095-005-4585-0
2005
Zhou S; Huang M; Xu A; Yang H; Duan W; Paxton JW, 2005, 'Prediction of herb-drug metabolic interactions: A simulation study', Phytotherapy Research, vol. 19, pp. 464 - 471, http://dx.doi.org/10.1002/ptr.1559
2005
Wang Q; Ting WL; Yang H; Wong PT, 2005, 'High doses of simavastatin upregulate dopamine D(1) and D(2) receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase', British Journal of Pharmacology, vol. 144, pp. 933 - 939, http://dx.doi.org/10.1038/sj.bjp.0706106
2005
Wang P; Zhang Y; Li H; Chieu HK; Munn AL; Yang H, 2005, 'AAA ATPases regulate membrane association of yeast oxysterol binding proteins and cellular sterol metabolism', European Molecular Biology Organization, vol. 24, pp. 2989 - 2999, http://dx.doi.org/10.1038/sj.emboj.7600764
2005
Low CP; Liew LP; Pervaiz S; Yang H, 2005, 'Apoptosis and lipoapoptosis in the fission yeast Schizosaccharomyces pombe', FEMS Yeast Research, vol. 5, pp. 1199 - 1206, http://dx.doi.org/10.1016/j.femsyr.2005.07.004
2005
Low C; Liew L; Pervaiz S; Yang H, 2005, 'Apoptosis and lipoapoptosis in yeast', Human Genetics, vol. 5, pp. 1199 - 1206
2005
Gao Y; Gao H; Chan E; Tang W; Xu A; Yang H; Huang M; Lan J; Li X; Duan W; Xu C; Zhou S, 2005, 'Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from ganoderma lucidum, in mice', Immunological Investigations, vol. 34, pp. 171 - 198, http://dx.doi.org/10.1081/IMM-200055813
2005
Armstrong JS; Whiteman M; Yang H; Jones DP; Sternberg P, 2004, 'Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells', Investigative Ophthalmology and Visual Science, vol. 45, pp. 4183 - 4189, http://dx.doi.org/10.1167/iovs.04-0570
2004
Kim K; Shin YK; Park J; Kim JH; Yang H; Han DM; Paik Y, 2004, 'Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents', Biochemical and Biophysical Research Communications, vol. 2319, pp. 911 - 919, http://dx.doi.org/10.1016/j.bbrc.2004.05.076
2004
Armstrong J; Whiteman M; Yang H; Jones DP, 2004, 'The redox regulation of intermediary metabolism by a superoxide-acontase rheostat', BioEssays, vol. 26, pp. 894 - 900, http://dx.doi.org/10.1002/bies.20071
2004
Zhang SP; Ren J; Zhang Q; Munn AL; Armstrong J; Yang H, 2004, 'Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport.', Traffic (Malden), vol. 5, pp. 1017 - 1030, http://dx.doi.org/10.1111/j.1600-0854.2004.00241.x
2004
Armstrong J; Yang H; Duan W; Whiteman M, 2004, 'Cytochrome bc1 regulates the mitochondrial permeability transition by two distinct pathways', The Journal of Biological Chemistry, vol. 279, pp. 50420 - 50428, http://dx.doi.org/10.1074/jbc.M408882200
2004
Zhang SP; Ren J; Zhang Q; Armstrong J; Munn AL; Yang H, 2004, 'Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells', Traffic (Malden), vol. 5, pp. 1017 - 1030
2004
Yeo SC; Xu LL; Ren J; Boulton VJ; Wagle MD; Liu CF; Ren G; Wong P; Zahn DR; Sasajala P; Yang H; Piper RD; Munn AL, 2003, 'Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae', Journal of Cell Science, vol. 116, pp. 3957 - 3970, http://dx.doi.org/10.1242/jcs.00751
2003
Tan JH; Low PS; Tan YS; Tong MC; Saha N; Yang H; Heng CK, 2003, 'ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore', Human Genetics, vol. 113, pp. 106 - 117
2003
Zhang Q; Chieu HK; Low C; Zhang SP; Heng CK; Yang H, 2003, 'Schizosaccharomyces pombe cells deficient in Triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase', The Journal of Biological Chemistry, vol. 278, pp. 47145 - 47155, http://dx.doi.org/10.1074/jbc.M306998200
2003
Woo WH; Yang H; Wong KP; Halliwell B, 2003, 'Sulphite oxidase gene expression in human brain and in other human and rat tissues', Biochemical and Biophysical Research Communications, vol. 305, pp. 619 - 623, http://dx.doi.org/10.1016/S0006-291X(03)00833-7
2003
Li T; Duan W; Yang H; Lee MK; Bte Mustafa F; Lee BH; Teo TS, 2001, 'Identification of two proteins, S14 and UIP1, that interact with UCH37', FEBS Letters, vol. 488, pp. 201 - 205, http://dx.doi.org/10.1016/S0014-5793(00)02436-4
2001
Li T; Naqvi NI; Yang H; Teo TS, 2000, 'Identification of a 26S proteasome-associated UCH in fission yeast', Biochemical and Biophysical Research Communications, vol. 272, pp. 270 - 275, http://dx.doi.org/10.1006/bbrc.2000.2767
2000
Liang JS; Wu X; Jiang H; Zhou M; Yang H; Angkeow P; Huang LS; Sturley SL; Ginsberg H, 1998, 'Translocation efficiency, susceptibility to proteasomal degradation, and lipid responsiveness of apolipoprotein B are determined by the presence of β sheet domains', Journal of Biological Chemistry, vol. 273, pp. 35216 - 35221, http://dx.doi.org/10.1074/jbc.273.52.35216
1998
Yang H; Cromley D; Wang H; Billheimer JT; Sturley SL, 1997, 'Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity', Journal of Biological Chemistry, vol. 272, pp. 3980 - 3985, http://dx.doi.org/10.1074/jbc.272.7.3980
1997
Arthington-Skaggs BA; Crowell DN; Yang H; Sturley SL; Bard M, 1996, 'Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway', FEBS Letters, vol. 392, pp. 161 - 165, http://dx.doi.org/10.1016/0014-5793(96)00807-1
1996
Yang H; Bard M; Bruner DA; Gleeson A; Deckelbaum RJ; Aljinovic G; Pohl TM; Rothstein R; Sturley SL, 1996, 'Sterol esterification in yeast: A two-gene process', Science, vol. 272, pp. 1353 - 1356, http://dx.doi.org/10.1126/science.272.5266.1353
1996
Book Chapters
add
Yang H, 2005, 'Metabolism of storage neutral lipids in yeast', in Daum G (ed.), Cell Biology and Dynamics of Yeast Lipids, edn. Original, Research Signpost, pp. 219 - 246
2005

Cholesterol, obesity, lipid droplets, insulin resistance, heart disease and cancer.