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Redox Biology, vol. 28, pp. 101374 - 101374,
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Childress ES; Salamoun JM; Hargett SR; Alexopoulos SJ; Chen SY; Shah DP; Santiago-Rivera J; Garcia CJ; Dai Y; Tucker SP; Hoehn KL; Santos WL, 2020, 'Oxadiazolo[3,4- b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis',
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Emerging Microbes and Infections, vol. 8, pp. 624 - 636,
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Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms',
Journal of Biological Chemistry, vol. 294, pp. 16740 - 16755,
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Gemta LF; Siska PJ; Nelson ME; Gao X; Liu X; Locasale JW; Yagita H; Slingluff CL; Hoehn KL; Rathmell JC; Bullock TNJ, 2019, 'Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8
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Science Immunology, vol. 4,
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Huo Y; Buckton LK; Bennett JL; Smith EC; Byrne FL; Hoehn KL; Rahimi MN; McAlpine SR, 2019, 'Delivering bioactive cyclic peptides that target Hsp90 as prodrugs',
Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 34, pp. 728 - 739,
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Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells',
Scientific Reports, vol. 9, pp. 15665,
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Cantley J; Davenport A; Vetterli L; Nemes NJ; Whitworth PT; Boslem E; Thai LM; Mellett N; Meikle PJ; Hoehn KL; James DE; Biden TJ, 2019, 'Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass',
Diabetologia, vol. 62, pp. 99 - 111,
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Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function',
Journal of Immunology, vol. 202, pp. 1826 - 1832,
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Serasinghe MN; Gelles JD; Li K; Zhao L; Abbate F; Syku M; Mohammed JN; Badal B; Rangel CA; Hoehn KL; Celebi JT; Chipuk JE, 2018, 'Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition',
Cell Death and Disease, vol. 9,
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Fazakerley DJ; Chaudhuri R; Yang P; Maghzal GJ; Thomas KC; Krycer JR; Humphrey SJ; Parker BL; Fisher-Wellman KH; Meoli CC; Hoffman NJ; Diskin C; Burchfield JG; Cowley MJ; Kaplan W; Modrusan Z; Kolumam G; Yang JYH; Chen DL; Samocha-Bonet D; Greenfield JR; Hoehn KL; Stocker R; James DE, 2018, 'Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance',
eLife, vol. 7,
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Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism',
Nature Communications, vol. 9,
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Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer',
Oncotarget, vol. 9, pp. 5786 - 5796,
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Chaudhuri R; Krycer JR; Fazakerley DJ; Fisher-Wellman KH; Su Z; Hoehn KL; Yang JYH; Kuncic Z; Vafaee F; James DE, 2018, 'The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes',
Scientific Reports, vol. 8,
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Burchfield JG; Kebede MA; Meoli CC; Stöckli J; Whitworth PT; Wright AL; Hoffman NJ; Minard AY; Ma X; Krycer JR; Nelson ME; Tan SX; Yau B; Thomas KC; Wee NKY; Khor EC; Enriquez RF; Vissel B; Biden TJ; Baldock PA; Hoehn KL; Cantley J; Cooney GJ; James DE; Fazakerley DJ, 2018, 'High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice',
Journal of Biological Chemistry, vol. 293, pp. 5731 - 5745,
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Byrne FL; Hargett SR; Lahiri S; Roy RJ; Berr SS; Caldwell SH; Hoehn KL, 2018, 'Serial MRI imaging reveals minimal impact of ketogenic diet on established liver tumor growth',
Cancers, vol. 10,
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Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice',
American Journal of Physiology - Endocrinology and Metabolism, vol. 315, pp. E286 - E293,
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Childress ES; Alexopoulos SJ; Hoehn KL; Santos WL, 2018, 'Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential',
Journal of Medicinal Chemistry, vol. 61, pp. 4641 - 4655,
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Taddeo EP; Hargett SR; Lahiri S; Nelson ME; Liao JA; Li C; Slack-Davis JK; Tomsig JL; Lynch KR; Yan Z; Harris TE; Hoehn KL, 2017, 'Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3',
Scientific Reports, vol. 7,
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Krycer JR; Yugi K; Hirayama A; Fazakerley DJ; Quek LE; Scalzo R; Ohno S; Hodson MP; Ikeda S; Shoji F; Suzuki K; Domanova W; Parker BL; Nelson ME; Humphrey SJ; Turner N; Hoehn KL; Cooney GJ; Soga T; Kuroda S; James DE, 2017, 'Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism',
Cell Reports, vol. 21, pp. 3536 - 3547,
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Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival',
Nature Communications, vol. 8,
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Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer',
Gynecologic Oncology, vol. 147, pp. 654 - 662,
http://dx.doi.org/10.1016/j.ygyno.2017.10.0062017
Gordon HM; Majithia N; MacDonald PE; Fox JEM; Sharma PR; Byrne FL; Hoehn KL; Evans-Molina C; Langman L; Brayman KL; Nunemaker CS, 2017, 'STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation',
Endocrine, vol. 56, pp. 528 - 537,
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Biwer LA; Taddeo EP; Kenwood BM; Hoehn KL; Straub AC; Isakson BE, 2016, 'Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition',
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, pp. 671 - 679,
http://dx.doi.org/10.1016/j.bbalip.2016.04.0142016
Laker RC; Taddeo EP; Akhtar YN; Zhang M; Hoehn KL; Yan Z, 2016, 'The mitochondrial permeability transition pore regulator cyclophilin D exhibits tissue-specific control of metabolic homeostasis',
PLoS ONE, vol. 11,
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Brandon AE; Stuart E; Leslie SJ; Hoehn KL; James DE; Kraegen EW; Turner N; Cooney GJ, 2016, 'Minimal impact of age and housing temperature on the metabolic phenotype of Acc2
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Journal of Endocrinology, vol. 228, pp. 127 - 134,
http://dx.doi.org/10.1530/JOE-15-04442016
Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice',
Scientific Reports, vol. 6,
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Narayanan S; Nieh AH; Kenwood BM; Davis CA; Tosello-Trampont AC; Elich TD; Breazeale SD; Ward E; Anderson RJ; Caldwell SH; Hoehn KL; Hahn YS, 2016, 'Distinct roles for intracellular and extracellular lipids in hepatitis C virus infection',
PLoS ONE, vol. 11,
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Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing',
Journal of Pathology, vol. 239, pp. 3 - 5,
http://dx.doi.org/10.1002/path.47022016
Bajwa A; Rosin DL; Chroscicki P; Lee S; Dondeti K; Ye H; Kinsey GR; Stevens BK; Jobin K; Kenwood BM; Hoehn KL; Lynch KR; Okusa MD, 2015, 'Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury',
Journal of the American Society of Nephrology, vol. 26, pp. 908 - 925,
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Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth',
Molecular Cell, vol. 57, pp. 537 - 551,
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Chaudhuri R; Khoo PS; Tonks K; Junutula JR; Kolumam G; Modrusan Z; Samocha-Bonet D; Meoli CC; Hocking S; Fazakerley DJ; Stöckli J; Hoehn KL; Greenfield JR; Yang JYH; James DE, 2015, 'Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity',
npj Systems Biology and Applications, vol. 1,
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Kenwood BM; Calderone JA; Taddeo EP; Hoehn KL; Santos WL, 2015, 'Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers',
Bioorganic and Medicinal Chemistry Letters, vol. 25, pp. 4858 - 4861,
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Serasinghe MN; Wieder SY; Renault TT; Elkholi R; Asciolla JJ; Yao JL; Jabado O; Hoehn K; Kageyama Y; Sesaki H; Chipuk JE, 2015, 'Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors',
Molecular Cell, vol. 57, pp. 521 - 536,
http://dx.doi.org/10.1016/j.molcel.2015.01.0032015
Hargett SR; Walker NN; Hussain SS; Hoehn KL; Keller SR, 2015, 'Deletion of the rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice',
American Journal of Physiology - Endocrinology and Metabolism, vol. 309, pp. E233 - E245,
http://dx.doi.org/10.1152/ajpendo.00007.20152015
Modesitt SC; Hallowell PT; Slack-Davis JK; Michalek RD; Atkins KA; Kelley SL; Arapovic S; Shupnik MA; Hoehn K, 2015, 'Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life',
Gynecologic Oncology, vol. 138, pp. 238 - 245,
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Cronk SM; Kelly-Goss MR; Ray HC; Mendel TA; Hoehn KL; Bruce AC; Dey BK; Guendel AM; Tavakol DN; Herman IM; Peirce SM; Yates PA, 2015, 'Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy',
Stem Cells Translational Medicine, vol. 4, pp. 459 - 467,
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Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine',
Journal of Hepatology, vol. 62, pp. 599 - 606,
http://dx.doi.org/10.1016/j.jhep.2014.10.0242015
Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1',
Biochemical Journal, vol. 471, pp. 243 - 253,
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Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation',
Molecular Metabolism, vol. 3, pp. 419 - 431,
http://dx.doi.org/10.1016/j.molmet.2014.02.0042014
Laker RC; Lillard TS; Okutsu M; Zhang M; Hoehn KL; Connelly JJ; Yan Z, 2014, 'Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring',
Diabetes, vol. 63, pp. 1605 - 1611,
http://dx.doi.org/10.2337/db13-16142014
Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2014, 'Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity',
Journal of Immunology, vol. 192, pp. 3190 - 3199,
http://dx.doi.org/10.4049/jimmunol.13029852014
Laker RC; Xu P; Ryall KA; Sujkowski A; Kenwood BM; Chain KH; Zhang M; Royal MA; Hoehn KL; Driscoll M; Adler PN; Wessells RJ; Saucerman JJ; Yan Z, 2014, 'A novel mitotimer reporter gene for mitochondrial content, structure, stress, and damage in vivo',
Journal of Biological Chemistry, vol. 289, pp. 12005 - 12015,
http://dx.doi.org/10.1074/jbc.M113.5305272014
Taddeo EP; Laker RC; Breen DS; Akhtar YN; Kenwood BM; Liao JA; Zhang M; Fazakerley DJ; Tomsig JL; Harris TE; Keller SR; Chow JD; Lynch KR; Chokki M; Molkentin JD; Turner N; James DE; Yan Z; Hoehn KL, 2014, 'Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle',
Molecular Metabolism, vol. 3, pp. 124 - 134,
http://dx.doi.org/10.1016/j.molmet.2013.11.0032014
Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer',
Cancer Research, vol. 74, pp. 5832 - 5845,
http://dx.doi.org/10.1158/0008-5472.CAN-14-02542014
Caldwell S; Hoehn KL; Hahn YS, 2013, 'The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil',
Hepatology, vol. 57, pp. 1684 - 1687,
http://dx.doi.org/10.1002/hep.260912013
Kenwood BM; Weaver JL; Byrne FL; Murrow BA; Tomsig JL; Cameron Coleman G; Yan Z; Lynch KR; Bayliss DA; Hoehn KL; Bajwa A; Huang L; Okusa MD; Poon IK; Ravichandran KS; Divakaruni AS; Saucerman JJ; Smith JS; Holmes JW; Rogers GW; Lo RH; Columbus L; Okabe K; Uchiyama S; Calderone JA; Santos WL, 2013, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane',
Molecular Metabolism,
http://dx.doi.org/10.1016/j.molmet.2013.11.0052013
Lira VA; Okutsu M; Zhang M; Greene NP; Laker RC; Breen DS; Hoehn KL; Yan Z, 2013, 'Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance',
FASEB Journal, vol. 27, pp. 4184 - 4193,
http://dx.doi.org/10.1096/fj.13-2284862013
Patel SA; Hoehn KL; Lawrence RT; Sawbridge L; Talbot NA; Tomsig JL; Turner N; Cooney GJ; Whitehead JP; Kraegen E; Cleasby ME, 2012, 'Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity',
Endocrinology, vol. 153, pp. 5231 - 5246,
http://dx.doi.org/10.1210/en.2012-13682012
Hoehn KL; Turner N; Cooney GJ; James DE, 2012, 'Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice (Journal of Biological Chemistry (2012) 287, (15801))',
Journal of Biological Chemistry, vol. 287, pp. 20468,
http://dx.doi.org/10.1074/jbc.A112.3569152012
Modesitt SC; Hsu JY; Chowbina SR; Lawrence RT; Hoehn KL, 2012, 'Not all fat is equal: Differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer',
International Journal of Gynecological Cancer, vol. 22, pp. 732 - 741,
http://dx.doi.org/10.1097/IGC.0b013e31825104962012
Hoehn KL; Turner N; Cooney GJ; James DE, 2012, 'Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice',
The Journal of Biological Chemistry, vol. 287, pp. 15801,
http://dx.doi.org/10.1074/jbc.O112.3569152012
Park D; Han CZ; Elliott MR; Kinchen JM; Trampont PC; Das S; Collins S; Lysiak JJ; Hoehn KL; Ravichandran KS, 2011, 'Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein',
Nature, vol. 477, pp. 220 - 224,
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Larance M; Rowland AF; Hoehn KL; Humphreys D; Preiss T; Guilhaus M; James DE, 2010, 'Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3',
Molecular and Cellular Proteomics, vol. 9, pp. 682 - 694,
http://dx.doi.org/10.1074/mcp.M900435-MCP2002010
Richards AA; Colgrave ML; Zhang J; Webster J; Simpson F; Preston E; Wilks D; Hoehn KL; Stephenson M; Macdonald GAM; Prins J; Cooney GJ; Xu A; Whitehead JR, 2010, 'Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation',
Molecular Endocrinology, vol. 24, pp. 229 - 239,
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Hoehn KL; Turner N; Swarbrick MM; Wilks D; Preston E; Phua Y; Joshi H; Furler SM; Larance M; Hegarty BD; Leslie SJ; Pickford R; Hoy AJ; Kraegen EW; James DE; Cooney GJ; Hegarty , 2010, 'Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity',
Cell Metabolism, vol. 11, pp. 70 - 76,
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Hoehn KL; Holland WL; Knotts TA; Summers SA, 2010, 'The etiology of obesity-induced insulin resistance', Insulin Resistance: Symptoms, Causes and Treatment, pp. 205 - 238
2010
Crowe SM; Wu LE; Economou C; Turpin S; Matzaris M; Hoehn KL; Hevener A; James DE; Duh E; Watt M, 2009, 'Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity',
Cell Metabolism, vol. 10, pp. 40 - 47,
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Hoehn KL; Holland WL; Knotts TA; Summers SA, 2009, 'The etiology of obesity-induced insulin resistance', Diabetes Mellitus Research Advances, pp. 99 - 132
2009
Hoehn K; Salmon A; Hohnen-Behrens C; Turner N; Hoy A; Maghzal G; Stocker R; Van remmen H; Kraegen E; Cooney GJ; Richardson A; James DE, 2009, 'Insulin resistance is a cellular antioxidant defense mechanism',
Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 17787 - 17792,
http://dx.doi.org/10.1073/pnas.09023801062009
Yip M; Ramm G; Larance MC; Hoehn K; Wagner M; Guilhaus M; James DE, 2008, 'CaMKII-Mediated Phosphorylation of the Myosin Motor Myolc Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes',
Cell Metabolism, vol. 8, pp. 384 - 398,
http://dx.doi.org/10.1016/j.cmet.2008.09.0112008
Hoehn K; Hohnen-Behrens C; Cederberg A; Wu LE; Turner N; Yuasa T; Ebina Y; James DE, 2008, 'IRS1-independent defects define major nodes of insulin resistance',
Cell Metabolism, vol. 7, pp. 421 - 433,
http://dx.doi.org/10.1016/j.cmet.2008.04.0052008
Turner N; Bruce CR; Beale S; Hoehn K; So T; Rolph MS; Cooney GJ, 2007, 'Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle - Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents',
Diabetes, vol. 56, pp. 2085 - 2092,
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Holland WL; Knotts TA; Chavez JA; Wang LP; Hoehn KL; Summers SA, 2007, 'Lipid mediators of insulin resistance.', Nutrition reviews, vol. 65
2007
Holland WL; Brozinick JT; Wang LP; Hawkins ED; Sargent KM; Liu Y; Narra K; Hoehn KL; Knotts TA; Siesky A; Nelson DH; Karathanasis SK; Fontenot GK; Birnbaum MJ; Summers SA, 2007, 'Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance',
Cell Metabolism, vol. 5, pp. 167 - 179,
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