Li Zhang

Senior Lecturer

Dr Li Zhang received her MBBS degree from Fudan University in China and PhD degree from the University of Cambridge in the UK. Dr Zhang was a clinician at the China-Japan Friendship Hospital in Beijing prior to her PhD study. She worked as a postdoctoral fellow at the Institute of Molecular and Cell Biology in National University of Singapore before joining the University of New South Wales (UNSW). Dr Zhang was appointed as a Senior Lecturer in the School of Biotechnology and Biomolecular Sciences (BABS) at UNSW in 2008.

Education

  • MB BS, Fudan University, Shanghai, China
  • PhD, University of Cambridge, UK

Research

Dr Li Zhang's group investigates bacterial species that cause or prevent inflammatory diseases and cancers of the gastrointestinal tract.  They study bacterial genomes, bacterial virulence factors, interactions of bacterial pathogens and gut microbiome with the immune system, and novel antimicrobial agents. Dr Zhang's earlier research was on autoimmune diseases. 

Dr Li Zhang is a pioneering researcher in the field of human hosted Campylobacter species and inflammatory bowel disease (IBD). Dr Zhang hypothesized that some strains of Campylobacter concisus, a bacterium that usually colonises the human oral cavity, have enteric pathogenicity and are the initiator of a subgroup of human IBD. Research in Dr Zhang’s group has provided critical information to this emerging research field, including disease association, C. concisus natural colonisation site, C. concisus metabolic pathways and bacterial genomic features. They recently identified a novel C. concisus plasmid (pICON) and a novel toxin gene csep1, both are associated with active Crohn's disease (one type IBD), suggesting that pICON plasmid and csep1 gene are the potential bacterial markers for identification of virulent C. concisus strains that cause a subgroup of Crohn's disease. Patients with CD who carry pICON positive C. concisus strains are more likely to develop complications.  

The second aspect of research in Dr Zhang's group is on the impact of microbes on immune regulation.  Dr Zhang hypothesized that chronic infection and inflammation may impact on PD-L1/PD1 blockade therapy.  https://doi.org/10.3389/fimmu.2018.00374  . This publication received high attention in the scientific community (current views rank top 94% and downloads rank top 93%).  The research group has recently found that some commensal gut bacterial species up-regulate intestinal epithelial expression of PD-L1 under inflammatory conditions  http://dx.doi.org/10.1128/IAI.00618-20. On-going research in Dr Zhang's laboratory is investigating the mechanisms by which different gut bacterial species impact on immunotherapy.  

  • Selected Publications

Liu F, Chen S, Luu LDW, Lee SA, Tay ACY, Wu R, Riordan SM, Lan R, Liu L, Zhang L, 2020, 'Analysis of complete Campylobacter concisus genomes identifies genomospecies features, secretion systems and novel plasmids and their association with severe ulcerative colitis.', Microbial Genomics, https://doi.org/10.1099/mgen.0.000457

Lee SA; Wang Y; Liu F; Riordan SM; Liu L; Zhang L, 2020, 'Escherichia coli K12 upregulates PD-L1 expression in IFN-γ sensitized intestinal epithelial cells via the NF-κB pathway.', Infect Immunhttp://dx.doi.org/10.1128/IAI.00618-20

Liu F; Ma R; Tay CYA; Octavia S; Lan R; Chung HKL; Riordan SM; Grimm MC; Leong RW; Tanaka MM; Connor S; Zhang L, 2018, 'Genomic analysis of oral Campylobacter concisus strains identified a potential bacterial molecular marker associated with active Crohn's disease', Emerging Microbes and Infections, vol. 7, http://dx.doi.org/10.1038/s41426-018-0065-6

Wang Y; Ma R; Liu F; Lee SA; Zhang L, 2018, 'Modulation of Gut Microbiota: A Novel Paradigm of Enhancing the Efficacy of Programmed Death-1 and Programmed Death Ligand-1 Blockade Therapy. Front. Immunol.   https://doi.org/10.3389/fimmu.2018.00374

Liu F; Ma R; Wang Y; Zhang L, 2018, 'The clinical importance of campylobacter concisus and other human hosted Campylobacter species', Frontiers in Cellular and Infection Microbiology, vol. 8, http://dx.doi.org/10.3389/fcimb.2018.00243

Chung HKL; Tay A; Octavia S; Chen J; Liu F; Ma R; Lan R; Riordan SM; Grimm MC; Zhang L, 2016, 'Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep38442

Zhang L, 2015, 'Oral Campylobacter species: Initiators of a subgroup of inflammatory bowel disease?', World Journal of Gastroenterology, vol. 21, pp. 9239 - 9244, http://dx.doi.org/10.3748/wjg.v21.i31.9239

Lastovica AJ; On SLW; Zhang L, 2014, 'The family Campylobacteraceae', in Moreira AP B; Meirelles PM; Thompson F (ed.), The Prokaryotes, Springer Heidelberg, New York Dordrecht London, pp. 307 - 335, http://dx.doi.org/10.1007/978-3-642-39044-9

Mahendran V; Riordan S; Grimm M; Tran TAT; Major J; Kaakoush NO; Mitchell HM; Zhang L, 2011, 'Prevalence of Campylobacter species in adult Crohn's disease and the preferential colonization sites of Campylobacter species in the human intestine', PLoS ONE, vol. 6, pp. 1 - 7, http://dx.doi.org/10.1371/journal.pone.0025417

Zhang L; Budman V; Day AS; Mitchell HM; Lemberg DA; Riordan SM; Grimm M; Leach ST; Ismail Y, 2010, 'Isolation and detection of Campylobacter concisus from saliva of healthy individuals and patients with inflammatory bowel disease', Journal of Clinical Microbiology, vol. 48, pp. 2965 - 2967, http://dx.doi.org/10.1128/JCM.02391-09

Zhang L; Man S; Day AS; Leach ST; Lemberg DA; Dutt S; Stormon MO; Otley AR; O Loughlin E; Magoffin A; Ng P; Mitchell HM, 2009, 'Detection and isolation of Campylobacter species other than C. jejuni from children with Crohn`s disease', Journal of Clinical Microbiology, vol. 47, pp. 453 - 455, http://dx.doi.org/10.1128/JCM.01949-08

Zhang L; Jayne DRW; Zhao MH; Lockwood CM; Oliveira DBG, 1995, 'Distribution of MHC class II alleles in primary systemic vasculitis', Kidney International, vol. 47, pp. 294 - 298, http://dx.doi.org/10.1038/ki.1995.37

  • Full List of Publications and Citations

Dr Zhang's full list of publications and citations can be found on Google Scholar.

  • Editorial Board Member

World Journal of Gastroenterology since 2017

  • PhD and Masters by Research Student Supervision

As the primary supervisor, Dr Li Zhang has supervised 12 higher degree research students to completion at UNSW since 2008 (six PhD and six Masters by Research students).

Current supervision areas include:

  • Genomic and proteomic analysis of the pathogenicity of Campylobacter concisus and other emerging bacterial pathogens
  • Microbes and their pathogenic mechanisms in IBD and other gastrointestinal diseases
  • Gut microbiota and immunotherapy 
  • Novel strategies to modify microbiota and to combat antimicrobial resistance
  • Honours Research Project Supervision

As the primary supervisor, Dr Zhang has supervised 23 honours degree research students to completion at UNSW since 2008. For current available projects, please see the school honours project book.

  • Research Funding

  • 2015 - ongoing Government contract: $120,000. The role of oral Campylobacter in gastrointestinal diseases (Li Zhang)

  • 2018  UNSW Science Silverstar Award: $20,000 for NHMRC APP1142726, Campylobacter concisus novel plasmids and genomic islands predict phenotypes and clinical outcomes of inflammatory bowel disease (Li Zhang, Michael Grimm, Stephen Riordan, Rupert Leong, Ruiting Lan)

  • 2017 Faculty research grant: $12,000. Genomic analysis of IBD-associated Campylobacter species (Li Zhang)

  • 2009 - 2010 The Eli and Edythe L. Broad Foundation USA, IBD-0273R, $148,837. Investigation of the possible role of non-jejuni Campylobacter species in inflammatory bowel disease (Li Zhang)

  • 2008 - 2010 NHMRC (APP ID 510230): $349,875. Exclusion enteral nutrition in children with Crohn's disease (Day A, Mitchell H, Leach S, Li Zhang)

  • 2008 - 2010 NHMRC (APP ID 510113): $414,375. Investigation of the role of specific mucous associated bacteria in children and young adults with Crohn's disease (Mitchell H, Day A, Otley A, Li Zhang).

Undergraduate Teaching

  • BABS 3041 (Immunology): Dr Zhang has been the course coordinator and principal lecturer since 2012.

  • Medical Microbiology: Dr Zhang is the coordinator and principal lecturer for the medical microbiology component in UNSW medical program (Phase I, Phase II and Phase III).

  • Medical Immunology: Dr Zhang is a lecturer for the immunology component in UNSW medicine Foundations course.

  • BABS 3081 (Bacteria and Disease): Dr Zhang delivers three lectures for this course.

Awards

  • 2020                            BABS T1 Titans of Teaching Award Runner-up (Best Large Class Course): BABS3041 Immunology

  • 2019                            UNSW President Award Nominee

  • 2014                            BABS T1 Titans of Teaching Award (Best Large Class Course): BABS3041 Immunology


      

 
 

 

 

PUBLICATIONS

Journal articles
add
Yeow M; Liu F; Ma R; Williams TJ; Riordan SM; Zhang L, 2020, 'Analyses of energy metabolism and stress defence provide insights into Campylobacter concisus growth and pathogenicity', Gut Pathogens, vol. 12, http://dx.doi.org/10.1186/s13099-020-00349-6
2020
Drimousis S; Markus I; Murphy TV; Shevy Perera D; Phan-Thien KC; Zhang L; Liu L, 2020, 'Gender-related differences of tachykinin NK2 receptor expression and activity in human colonic smooth muscle', Journal of Pharmacology and Experimental Therapeutics, vol. 375, pp. 28 - 39, http://dx.doi.org/10.1124/JPET.120.265967
2020
Lee SA; Wang Y; Liu F; Riordan SM; Liu L; Zhang L, 2020, 'Escherichia coli K12 upregulates PD-L1 expression in IFN-γ sensitized intestinal epithelial cells via the NF-κB pathway', Infection and Immunity, http://dx.doi.org/10.1128/IAI.00618-20
2020
Liu F; Chen S; Luu LDW; Lee SA; Tay ACY; Wu R; Riordan SM; Lan R; Liu L; Zhang L, 2020, 'Analysis of complete Campylobacter concisus genomes identifies genomospecies features, secretion systems and novel plasmids and their association with severe ulcerative colitis', Microbial Genomics, http://dx.doi.org/10.1099/mgen.0.000457
2020
Yeh KM; Johansson O; Le H; Rao K; Markus I; Perera DS; Lubowski DZ; King DW; Zhang L; Chen H; Liu L, 2019, 'Cystic fibrosis transmembrane conductance regulator modulates enteric cholinergic activities and is abnormally expressed in the enteric ganglia of patients with slow transit constipation', Journal of Gastroenterology, vol. 30, http://dx.doi.org/10.1007/s00535-019-01610-9
2019
Lee SA; Liu F; Riordan SM; Lee CS; Zhang L, 2019, 'Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer', Frontiers in Oncology, vol. 9, http://dx.doi.org/10.3389/fonc.2019.00566
2019
Chen J; Liu F; Lee SA; Chen S; Zhou X; Ye P; Riordan SM; Liu L; Zhang L, 2019, 'Detection of IL-18 and IL-1β protein and mRNA in human oral epithelial cells induced by Campylobacter concisus strains', Biochemical and Biophysical Research Communications, vol. 518, pp. 44 - 49, http://dx.doi.org/10.1016/j.bbrc.2019.08.006
2019
Liu F; Lee SA; Riordan SM; Zhang L; Zhu L, 2019, 'Effects of Anti-Cytokine Antibodies on Gut Barrier Function', Mediators of inflammation, vol. 2019, pp. 7028253, http://dx.doi.org/10.1155/2019/7028253
2019
Liu F; Ma R; Tay CYA; Octavia S; Lan R; Chung HKL; Riordan SM; Grimm MC; Leong RW; Tanaka MM; Connor S; Zhang L, 2018, 'Genomic analysis of oral Campylobacter concisus strains identified a potential bacterial molecular marker associated with active Crohn's disease', Emerging Microbes and Infections, vol. 7, http://dx.doi.org/10.1038/s41426-018-0065-6
2018
Bazhin AV; Amedei A; Karakhanova S, 2018, 'Editorial: Immune Checkpoint Molecules and Cancer Immunotherapy', Frontiers in immunology, vol. 9, pp. 2878, http://dx.doi.org/10.3389/fimmu.2018.02878
2018
Liu F; Ma R; Wang Y; Zhang L, 2018, 'The clinical importance of campylobacter concisus and other human hosted Campylobacter species', Frontiers in Cellular and Infection Microbiology, vol. 8, http://dx.doi.org/10.3389/fcimb.2018.00243
2018
Wang Y; Liu F; Lee SAL; Zhang L, 2018, 'Modulation of Gut Microbiota: A Novel Paradigm of Enhancing the Efficacy of Programmed Death-1 and Programmed Death Ligand-1 Blockade Therapy', Frontiers in Immunology, http://dx.doi.org/10.3389/fimmu.2018.00374
2018
Ma R; Liu F; Yap SF; Lee H; Leong RW; Riordan SM; Grimm MC; Zhang L, 2018, 'The growth and protein expression of Inflammatory Bowel disease-associated Campylobacter concisus is affected by the derivatives of the food additive fumaric acid', Frontiers in Microbiology, vol. 9, http://dx.doi.org/10.3389/fmicb.2018.00896
2018
Rahman MM; Goff B; Zhang L; Roujeinikova A, 2018, 'Refolding, characterization, and preliminary X-ray crystallographic studies on the campylobacter concisus plasmid-encoded secreted protein Csep1p associated with Crohn’s disease', Crystals, vol. 8, http://dx.doi.org/10.3390/cryst8100391
2018
Diezmos EF; Markus I; Perera DS; Gan S; Zhang L; Sandow SL; Bertrand PP; Liu L, 2018, 'Blockade of pannexin-1 channels and purinergic P2X7 receptors shows protective effects against cytokines-induced colitis of human colonic mucosa', Frontiers in Pharmacology, vol. 9, http://dx.doi.org/10.3389/fphar.2018.00865
2018
Chung HKL; Tay A; Octavia S; Chen J; Liu F; Ma R; Lan R; Riordan SM; Grimm MC; Zhang L, 2017, 'Erratum: Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity', Scientific reports, vol. 7, pp. 41113, http://dx.doi.org/10.1038/srep41113
2017
Liu F; Ma R; Riordan SM; Grimm MC; Liu L; Wang Y; Zhang L, 2017, 'Azathioprine, mercaptopurine, and 5-aminosalicylic acid affect the growth of IBD-associated Campylobacter species and other enteric microbes', Frontiers in Microbiology, vol. 8, http://dx.doi.org/10.3389/fmicb.2017.00527
2017
Wang Y; Liu F; Zhang X; Chung HKL; Riordan SM; Grimm MC; Zhang S; Ma R; Lee SA; Zhang L, 2017, 'Campylobacter concisus genomospecies 2 is better adapted to the human gastrointestinal tract as compared with Campylobacter concisus genomospecies 1', Frontiers in Physiology, vol. 8, http://dx.doi.org/10.3389/fphys.2017.00543
2017
Chung HKL; Tay A; Octavia S; Chen J; Liu F; Ma R; Lan R; Riordan SM; Grimm MC; Zhang L, 2016, 'Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep38442
2016
Liu F; Lee H; Lan R; Zhang L, 2016, 'Zonula occludens toxins and their prophages in Campylobacter species', Gut Pathogens, vol. 8, http://dx.doi.org/10.1186/s13099-016-0125-1
2016
Mahendran V; Liu F; Riordan SM; Grimm MC; Tanaka MM; Zhang L, 2016, 'Examination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages', Gut Pathogens, vol. 8, http://dx.doi.org/10.1186/s13099-016-0101-9
2016
Ma R; Sapwell N; Chung HKL; Lee H; Mahendran V; Leong RW; Riordan SM; Grimm MC; Zhang L, 2015, 'Investigation of the effects of ph and bile on the growth of oral campylobacter concisus strains isolated from patients with inflammatory bowel disease and controls', Journal of Medical Microbiology, vol. 64, pp. 438 - 445, http://dx.doi.org/10.1099/jmm.0.000013
2015
Zhang L, 2015, 'Oral Campylobacter species: Initiators of a subgroup of inflammatory bowel disease?', World Journal of Gastroenterology, vol. 21, pp. 9239 - 9244, http://dx.doi.org/10.3748/wjg.v21.i31.9239
2015
Mahendran V; Octavia S; Demirbas OF; Sabrina S; Ma R; Lan R; Riordan SM; Grimm MC; Zhang L, 2015, 'Delineation of genetic relatedness and population structure of oral and enteric Campylobacter concisus strains by analysis of housekeeping genes', Microbiology (United Kingdom), vol. 161, pp. 1600 - 1612, http://dx.doi.org/10.1099/mic.0.000112
2015
Lee H; Ma R; Grimm MC; Riordan SM; Lan R; Zhong L; Raftery M; Zhang L, 2014, 'Examination of the anaerobic growth of Campylobacter concisus strains', International Journal of Microbiology, vol. 2014, http://dx.doi.org/10.1155/2014/476047
2014
Zhang L; Lee H; Grimm MC; Riordan SM; Day AS; Lemberg DA, 2014, 'Campylobacter concisus and inflammatory bowel disease', World Journal of Gastroenterology, vol. 20, pp. 1259 - 1267, http://dx.doi.org/10.3748/wjg.v20.i5.1259
2014
Mahendran V; Tan YS; Riordan SM; Grimm MC; Day AS; Lemberg DA; Octavia S; Lan R; Zhang L, 2013, 'The Prevalence and Polymorphisms of Zonula Occluden Toxin Gene in Multiple Campylobacter concisus Strains Isolated from Saliva of Patients with Inflammatory Bowel Disease and Controls', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0075525
2013
Ismail Y; Lee H; Riordan S; Grimm M; Zhang L, 2013, 'The effects of oral and enteric campylobacter concisus strains on expression of TLR4, MD-2, TLR2, TLR5 and COX-2 in HT-29 cells', PLoS ONE, vol. 8, pp. Article number e56888, http://dx.doi.org/10.1371/journal.pone.0056888
2013
Hallab JC; Leach ST; Zhang L; Mitchell HM; Oei J; Lui K; Day AS; Hallab J, 2013, 'Molecular characterization of bacterial colonization in the preterm and term infant's intestine', Indian Journal of Pediatrics, vol. 80, pp. 1 - 5, http://dx.doi.org/10.1007/s12098-012-0753-5
2013
Ismail Y; Mahendran V; Octavia S; Day AS; Riordan S; Grimm M; Lan R; Lemberg DA; Tran TAT; Zhang L, 2012, 'Investigation of the enteric pathogenic potential of oral campylobacter concisus strains isolated from patients with inflammatory bowel disease', PLoS One, vol. 7(5), pp. 1 - 11, http://dx.doi.org/10.1371/journal.pone.0038217
2012
Kovach Z; Kaakoush NO; Lamb S; Zhang L; Raftery MJ; Mitchell HM; Lamb S, 2011, 'Immunoreactive proteins of Campylobacter concisus, an emergent intestinal pathogen.', FEMS Immunology and Medical Microbiology, vol. 63, pp. 387 - 396, http://dx.doi.org/10.1111/j.1574-695X.2011.00864.x
2011
Mahendran V; Riordan S; Grimm M; Tran TAT; Major J; Kaakoush NO; Mitchell HM; Zhang L, 2011, 'Prevalence of Campylobacter species in adult Crohn's disease and the preferential colonization sites of Campylobacter species in the human intestine', PLoS ONE, vol. 6, pp. 1 - 7, http://dx.doi.org/10.1371/journal.pone.0025417
2011
Man S; Kaakoush NO; Leach ST; Nahidi L; Lu HK; Norman J; Day AS; Zhang L; Mitchell HM, 2010, 'Host attachment, invasion and stimulation of proinflammatory cytokines by Campylobacter concisus and other non-Campylobacter jejuni Campylobacter species', Journal of Infectious Diseases, vol. 202, pp. 1855 - 1865, http://dx.doi.org/10.1086/657316
2010
Kaakoush NO; Holmes J; Octavia S; Man S; Zhang L; Castano-Rodriguez N; Day AS; Leach ST; Lemberg DA; Dutt S; Stormon M; O'Loughlin EV; Magoffin A; Mitchell HM, 2010, 'Detection of Helicobacteraceae in intestinal biopsies of children with Crohn's disease', Helicobacter, vol. 15, pp. 549 - 557, http://dx.doi.org/10.1111/j.1523-5378.2010.00792.x
2010
Zhang L; Budman V; Day AS; Mitchell HM; Lemberg DA; Riordan SM; Grimm M; Leach ST; Ismail Y, 2010, 'Isolation and detection of Campylobacter concisus from saliva of healthy individuals and patients with inflammatory bowel disease', Journal of Clinical Microbiology, vol. 48, pp. 2965 - 2967, http://dx.doi.org/10.1128/JCM.02391-09
2010
Man S; Zhang L; Day AS; Leach ST; Lemberg DA; Mitchell HM, 2010, 'Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn’s disease', Inflammatory Bowel Diseases, vol. 16, pp. 1008 - 1016, http://dx.doi.org/10.1002/ibd.21157
2010
Zhang L; Man S; Day AS; Leach ST; Lemberg DA; Dutt S; Stormon MO; Otley AR; O Loughlin E; Magoffin A; Ng P; Mitchell HM, 2009, 'Detection and isolation of Campylobacter species other than C. jejuni from children with Crohn`s disease', Journal of Clinical Microbiology, vol. 47, pp. 453 - 455, http://dx.doi.org/10.1128/JCM.01949-08
2009
Zhang L; Man S; Day AS; Leach ST; Lemberg DA; Dutt S; Stormon MO; Otley AR; O Loughlin E; Magoffin A; Ng P; Mitchell HM, 2009, 'Campylobacter concisus: a New Character in the Crohn`s Disease Story? Reply', Journal of Clinical Microbiology, vol. 47, pp. 1614 - 1615, http://dx.doi.org/10.1128/JCM.00310-09
2009
Leach ST; Mitchell HM; Eng W; Zhang L; Day AS, 2008, 'Sustained modulation of intestinal bacteria by exclusive enteral nutrition used to treat children with Crohn`s disease', Alimentary Pharmacology and Therapeutics, vol. 28, pp. 724 - 733, http://dx.doi.org/10.1111/j.1365-2036.2008.03796.x
2008
Zhang L; Su P; Henriksson A; O Rourke JL; Mitchell HM, 2008, 'Investigation of the immunomodulatory effects of Lactobacillus casei and Bifidobacterium lactis on Helicobacter pylori infection', Helicobacter, vol. 13, pp. 183 - 190, http://dx.doi.org/10.1111/j.1523-5378.2008.00595.x
2008
Man S; Zhang L; Day AS; Leach ST; Mitchell HM, 2008, 'Detection of enterohepatic and gastric Helicobacter species in fecal specimens of children with Crohn`s disease', Helicobacter, vol. 13, pp. 234 - 238, http://dx.doi.org/10.1111/j.1523-5378.2008.00607.x
2008
Dong Q; Zhang L; Goh K; Forman D; O Rourke JL; Harris A; Mitchell HM, 2007, 'Identification and characterisation of ssrA in members of the Helicobacter genus', Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, vol. 92, pp. 301 - 307, http://dx.doi.org/10.1007/s10482-007-9152-8
2007
Zhang L; Mitchell HM, 2006, 'The roles of mucus-associated bacteria in inflammatory bowel disease', Drugs of Today, vol. 42, pp. 605 - 616, http://dx.doi.org/10.1358/dot.2006.42.9.1025694
2006
Zhang L; Day AS; McKenzie GL; Mitchell HM, 2006, 'Nongastric Helicobacter species detected in the intestinal tract of children', Journal of Clinical Microbiology, vol. 44, pp. 2276 - 2279, http://dx.doi.org/10.1128/JCM.02017-05
2006
Zhang L; Day AS; Dong Q; Mitchell HM, 2006, 'Avoiding errors in the identification and 16S rRNA sequencing data of members of the Helicobacteriaceae family detected in clinical samples', Helicobacter, vol. 11, pp. 131 - 133, http://dx.doi.org/10.1111/j.1523-5378.2006.00387.x
2006
Zhang L; Danon SJ; Grehan MJ; Lee A; Mitchell HM, 2005, 'Template DNA ratio can affect detection by genus-specificPCR-Denaturing gradient gel electrophoresis of bacteria present at lowabundance in mixed populations', Helicobacter, vol. 10, pp. 80 - 82, http://dx.doi.org/10.1111/j.1523-5378.2005.00294.x
2005
Zhang L; Danon SJ; Grehan MJ; Chan V; Lee A; Mitchell HM, 2005, 'Natural colonization with Helicobacter species and the development of inflammatory bowel disease in interleukin-10-deficient mice', Helicobacter, vol. 10, pp. 223 - 230, http://dx.doi.org/10.1111/j.1523-5378.2005.00314.x
2005
Chan V; Crocetti GR; Grehan MJ; Zhang L; Danon SJ; Lee A; Mitchell HM, 2005, 'Visualization of Helicobacter species within the murine cecal mucosa using specific fluorescence in situ hybridization', Helicobacter, vol. 10, pp. 114 - 124, http://dx.doi.org/10.1111/j.1523-5378.2005.00298.x
2005
Chan SL; Tan KO; Zhang L; Yee KSY; Ronca F; Chan MY; Yu VC, 1999, 'F1Aα, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis', Journal of Biological Chemistry, vol. 274, pp. 32461 - 32468, http://dx.doi.org/10.1074/jbc.274.45.32461
1999
Zhang L; Jayne DRW; Zhao MH; Lockwood CM; Oliveira DBG, 1995, 'Distribution of MHC class II alleles in primary systemic vasculitis', Kidney International, vol. 47, pp. 294 - 298, http://dx.doi.org/10.1038/ki.1995.37
1995
Finn JE; Zhang L; Agrawal S; Jayne DRW; Oliveira DBG; Mathieson PW, 1994, 'Molecular analysis of C3 allotypes in patients with systemic vasculitis', Nephrology Dialysis Transplantation, vol. 9, pp. 1564 - 1567, http://dx.doi.org/10.1093/oxfordjournals.ndt.a092703
1994
ZHANG L; WEETMAN AP; BASSENDINE M; OLIVEIRA DBG, 1994, 'Major Histocompatibility Complex Class‐II Alleles in Primary Biliary Cirrhosis', Scandinavian Journal of Immunology, vol. 39, pp. 104 - 106, http://dx.doi.org/10.1111/j.1365-3083.1994.tb03346.x
1994
Zhang L; Jayne DRW; Oliveira DBG, 1993, 'Anti-idiotype Antibodies to Anti-mitochondrial Antibodies in the Sera of Patients with Primary Biliary Cirrhosis', Journal of Autoimmunity, vol. 6, pp. 93 - 105, http://dx.doi.org/10.1006/jaut.1993.1008
1993
ZHANG L; WEETMAN AP; JAYNE DRW; TURNER I; YEAMAN SJ; BASSENDINE MF; OLIVEIRA DBG, 1992, 'Anti‐mitochondrial antibody IgG subclass distribution and affinity in primary biliary cirrhosis', Clinical & Experimental Immunology, vol. 88, pp. 56 - 61, http://dx.doi.org/10.1111/j.1365-2249.1992.tb03039.x
1992
Zhang L; Weetman AP; Friedmann PS; Oliveira DBG, 1991, 'HLA associations with alopecia areata', Tissue Antigens, vol. 38, pp. 89 - 91, http://dx.doi.org/10.1111/j.1399-0039.1991.tb01885.x
1991
Weetman AP; Zhang L; Tandon N; Edwards OM, 1991, 'HLA associations with autoimmune Addison's disease', Tissue Antigens, vol. 38, pp. 31 - 33, http://dx.doi.org/10.1111/j.1399-0039.1991.tb02032.x
1991
Tendon N; Zhang L; Weetman AP, 1991, 'HLA Associations with Hashimoto's thyroiditis', Clinical Endocrinology, vol. 34, pp. 383 - 386, http://dx.doi.org/10.1111/j.1365-2265.1991.tb00309.x
1991
WEETMAN AP; ZHANG L; WEBB S; SHINE B, 1990, 'ANALYSIS OF HLA‐DQB AND HLA‐DPB ALLELES IN Graves'DISEASE BY OLIGONUCLEOTIDE PROBING OF ENZYMATICALLY AMPLIFIED DNA', Clinical Endocrinology, vol. 33, pp. 65 - 71, http://dx.doi.org/10.1111/j.1365-2265.1990.tb00466.x
1990
Book Chapters
add
Liu F; Ma R; Wang Y; Zhang L, 2020, 'The Clinical Importance of Campylobacter concisus and Other Human Hosted Campylobacter Species', in Interplay of infection and microbiome, http://dx.doi.org/10.3389/978-2-88963-926-7
2020
Ma R; Liu F; Yap SF; Lee H; Leong RW; Riordan SM; Grimm MC; Zhang L, 2019, 'The Growth and Protein Expression of Inflammatory Bowel Disease-Associated Campylobacter concisus Is Affected by the Derivatives of the Food Additive Fumaric Acid', in Pandol SJ; Li Z (ed.), Xenobiotics and the Gut Microbiome in Health and Disease, Frontiers Media SA, pp. 96 - 110, http://dx.doi.org/10.3389/978-2-88963-082-0
2019
Wang Y; Ma R; Liu F; Lee SA; Zhang L, 2019, 'Modulation of Gut Microbiota: A Novel Paradigm of Enhancing the Efficacy of Programmed Death-1 and Programmed Death Ligand-1 Blockade Therapy', in Bazhin AV; Amedai A; Karakhanova S (ed.), Immune Checkpoint Molecules and Cancer Immunotherapy, Frontiers Media SA, pp. 164 - 176, http://dx.doi.org/10.3389/978-2-88945-732-8
2019
Lastovica AJ; On SLW; Zhang L, 2014, 'The family Campylobacteraceae', in Moreira APB; Meirelles PM; Thompson F (ed.), The Prokaryotes, Springer Heidelberg, New York Dordrecht London, pp. 307 - 335, http://dx.doi.org/10.1007/978-3-642-39044-9
2014
Conference Papers
add
Liu F; Zhang L, 2016, 'The virulent fragments of Campylobacter concisus zonula occludens toxin', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, pp. 124 - 124, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000384664700221&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Conference Abstracts
add
Liu F; Ma R; Lee H; Riordan SM; Grimm MC; Leong RW; Zhang LI, 2015, 'Bile induces the release of zonula occludens toxin by Campylobacter concisus: a unique pathogenic mechanism by which oral Campylobacter species initiate a subgroup of human IBD', in Journal of Gastroenterology and Hepatology, Wiley: 12 months, Vol. 30, pp. 148 - 148, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900285&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2015
Lee H; Liu F; Mahendran V; Zhang L, 2014, 'Detection of the zonula occludens toxin expressed in Campylobacter concisus strains', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 29, pp. 10 - 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343863000019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Mahendran V; Lee H; Liu F; Zhang L, 2014, 'Detection of the zonula occludens toxin expressed in Campylobacter concisus strains (note this manual entry previously had incorrect article title, M Potter April 2015)', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 29 (Suppl. 2), pp. 10 - 26, http://onlinelibrary.wiley.com/doi/10.1111/jgh.12736_2/epdf
2014
Ma R; Sapwell N; Lee H; Mahendran V; Leong RW; Grimm MC; Riordan SM; Zhang L, 2014, 'The effects of gastrointestinal environmental factors on Campylobacter concisus growth', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 29, pp. 22 - 22, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343863000045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Mahendran V; Lee HY; Tan YS; Riordan SM; Grimm MC; Day AS; Lemberg DA; Octavia S; Lan R; Zhang L, 2013, 'The association between a tight junction toxin gene in Campylobacter concisus and inflammatory bowel disease', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, Vol. 28, pp. 14 - 14, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324106900026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2013
Wong SM; Day A; Lemberg D; Riordan S; Grimm MC; Budiman V; Mitchell H; Ismail Y; Zhang L, 2010, 'Antibiotic susceptibility of Campylobacter concisus isolated from patients with inflammatory bowel disease', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL PUBLISHING, INC, Vol. 25, pp. A80 - A80, http://dx.doi.org/10.1111/j.1440-1746.2010.06454.x
2010
Mitchell HM; Man SM; Leach S; Nahidi L; Norman J; Day AS; Zhang L; Tan S; Kaakoush NO, 2010, 'Campylobacter concisus: an emergent intestinal pathogen', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL PUBLISHING, INC, Vol. 25, pp. A82 - A82, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283321200223&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2010
Kaakoush NO; Holmes J; Octavia S; Man S; Zhang L; Castano-Rodriguez N; Day A; Leach ST; Lemberg DA; Dutt S; Storman M; O'Laughlin EV; Magoffin A; Mitchell HM, 2010, 'Do members of the Helicobacteraceae play a role in Crohn's disease?', in HELICOBACTER, WILEY-BLACKWELL PUBLISHING, INC, Rotterdam, NETHERLANDS, Vol. 15, pp. 315 - 315, presented at 23rd International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, Rotterdam, NETHERLANDS, 16 September 2010 - 18 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279986200015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2010
Mitchell HM; Zhang L; Man S; Day AS; Kaakoush NO, 2009, 'Members of the Helicobacteraceae Reside in Intestinal Tract of Children and may be Associated with Crohn`s Disease', in Helicobacter, Blackwell Publishing Inc, Malden, MA, USA, Vol. 14, pp. 323 - 324, presented at The European Helicobacter Study Group, Porto, Portugal, 17 September 2009 - 19 September 2009, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000268269300040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2009
Zhang L; Man S; Day S; Leach ST; Lemberg DA; Dutt S; Stormon MO; O Loughlin EV; Magoffin A; Mitchell HM, 2008, 'Investigation of the possible association between non-jejuni Campylobacter species and Crohn`s disease in Australian children', in Journal of Gastroenterology and Hepatology, Blackwell Publishing Asia, Carlton, Victoria, Australia, Vol. 23, pp. A220 - A220, presented at Journal of Gastroenterology and Hepatology, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000259960100091&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2008
Mitchell HM; Zhang L; Su P; Henriksson A; O Rourke JL, 2007, 'The immunomodulatory effect of probiotics, Lactobacillus casei, and Bifidobacterium lactis in Helicobacter pylori infection', in Helicobacter, Blackwell Publishing Inc, Malden, MA, USA, Vol. 12, pp. 406 - 406, presented at 20th International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation, Istanbul, TURKEY, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249017800091&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2007
Mitchell HM; Zhang L; Day AS; McKenzie GL, 2005, 'Detection of enterohepatic Helicobacter species and Wolinella succinogenes in biopsy specimens from children with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS)', in Helicobacter, Blackwell Publishing Inc, Copenhagen, DENMARK, Vol. 10, pp. 548 - 549, presented at 18th International Workshop on Gastrointestinal Pathology and Helicobactor, Copenhagen, DENMARK, 12 October 2005 - 14 October 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231951800280&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2005
Zhang L; Day A; McKenzie G; Mitchell HM, 2005, 'Detection of enterohepatic Helicobacter species and Wolinella succinogenes in biopsy specimens from children with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS)', in HELICOBACTER, BLACKWELL PUBLISHING, Copenhagen, DENMARK, Vol. 10, pp. 553 - 553, presented at 18th International Workshop on Gastrointestinal Pathology and Helicobactor, Copenhagen, DENMARK, 12 October 2005 - 14 October 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231951800295&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2005
Eng WR; Day AS; Leach S; Whitten K; Zhang L; Mitchell H, 2005, 'Exclusive enteral nutrition alters the intestinal microbiota of children with Crohn's disease', in GASTROENTEROLOGY, W B SAUNDERS CO, Chicago, IL, Vol. 128, pp. A511 - A511, presented at Annual Meeting of the American-Gastroenterological-Association/Digestive-Disease-Week, Chicago, IL, 14 May 2005 - 19 May 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000228619304141&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2005
Zhang L; Day AS; McKenzie G; Mitchell H, 2005, 'Detection of helicobacteraceae members in biopsy specimens from children with inflammatory bowel disease', in GASTROENTEROLOGY, W B SAUNDERS CO, Chicago, IL, Vol. 128, pp. A194 - A194, presented at Annual Meeting of the American-Gastroenterological-Association/Digestive-Disease-Week, Chicago, IL, 14 May 2005 - 19 May 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000228619301351&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2005