Marcel Dinger

Head of School

Marcel Dinger is Professor and Head of School for Biotechnology and Biomedical Sciences at UNSW Sydney.

Professor Dinger has more than 20 years experience in genomics as both an academic and entrepreneur. He was the founding CEO of Genome.One, one of the first companies in the world to provide clinical whole genome sequencing services. He is also founder of two successful IT companies and is the recent co-founder of a precision healthcare start-up, Pryzm Health. Marcel was the inaugural Head of the Kinghorn Centre for Clinical Genomics (KCCG) at the Garvan Institute of Medical Research from 2012-2018. 

Professor Dinger’s research laboratory seeks to establish new links between phenotype and genotype, particularly between rare and complex disease and underexplored regions of the genome, such as pseudogenes, repetitive elements, and those folding into non-canonical DNA structures or are transcribed into noncoding RNAs. Harnessing the potential of population scale genomic datasets, and sophisticated data science methods, the laboratory aims to bring an objective perspective to better understand how the genome stores information and how it is transacted in biology.

Professor Dinger graduated with a PhD in Biochemistry and Molecular Biology from the University of Waikato, New Zealand in 2003. Attracting more than 17,000 citations, he has (co)-authored more than 125 papers, many of which appear in the most high profile journals in the life sciences. In 2016, Marcel was admitted as a Fellow into the Faculty of Sciences of the Royal College of Pathologists of Australasia and is a Graduate of the Australian Institute of Company Directors. In 2019, Marcel was named in the Clarivate Analytics Highly Cited Researchers list from the Web of Science Group, which recognises scientists who have published a high number of papers that rank in the top 1% most-cited in their respective fields.

 

Highlighted publications

  1. Zeraati M, Langley DB, Schofield P, Moye AL, Rouet R, Hughes WE, Bryan TM, Dinger ME*, Christ D* (2018). I-motif DNA structures are formed in the nuclei of human cells. Nature Chemistry 10:631-637.
  2. Gloss BS, Dinger ME (2018). Realising the significance of noncoding functionality in clinical genomics. Experimental & Molecular Medicine 50:97.
  3. Bartonicek N, Clark MB, Quek XC, Torpy J, Pritchard AL, Maag JL, Gloss BS, Crawford J, Taft RJ, Hayward NK, Montgomery GW, Mattick JS, Mercer TR, Dinger ME (2017). Intergenic disease-associated regions are abundant in novel transcripts. Genome Biology 18:241.
  4. Signal B, Gloss BS, Dinger ME*, Mercer TR* (2017). Machine learning annotation of human branchpoints. Bioinformatics 34:920-927.
  5. Gloss BS, Signal B, Cheetham SW, Gruhl F, Kaczorowski D, Perkins AC, Dinger ME (2017). High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci. Scientific Reports 7:6731
  6. Zeraati M, Moye AL, Wong JW, Perera D, Cowley MJ, Christ DU, Bryan TM, Dinger ME (2017). Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression. Scientific Reports 7:708.
  7. Signal B, Gloss BS, Dinger ME (2016). Computational approaches for functional prediction and characterisation of long noncoding RNAs. Trends in Genetics 32:620-37.
  8. Bartonicek N, Maag JLV, Dinger ME (2016). Long noncoding RNAs in cancer: mechanisms of action and technological advancements. Molecular Cancer 15:43.
  9. Thomson DW, Dinger ME (2016). Endogenous microRNA sponges: evidence and controversy. Nature Reviews Genetics 17: 272–283.
  10. Gloss BS, Dinger ME (2015). The specificity of long noncoding RNA expression. Biochimica et Biophysica Acta 1859:16-22.
  11. Clark MB, Mercer TR, Bussotti G, Leonardi T, Haynes KR, Crawford J, Lê Cao K, Brunck ME, Thomas GP, Taft RJ, Nielsen LK, Enright AJ, Mattick JS and Dinger ME (2015). Quantitative profiling of long noncoding RNAs with targeted RNA sequencing. Nature Methods 12:392-395.
  12. Mercer TR, Clark MB, Anderson S, Brunck ME, Crawford J, Taft RJ, Nielsen LK, Dinger ME*, Mattick JS* (2015). Genome-wide discovery of human splicing branchpoints.Genome Research 25:290-303.
  13. Quek XC, Thomson, DW, Maag, JL, Bartonicek N, Signal B, Clark MB, Gloss BS and Dinger ME (2015). lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs. Nucleic Acids Research 43:D168-D173
  14. Cheetham S, Gruhl F, Mattick JS, Dinger ME. Long noncoding RNAs and the genetics of cancer (2013). Long noncoding RNAs and the genetics of cancer. British Journal of Cancer 108: 2419-25.
  15. Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME*, Mattick JS* (2012). Genome-wide analysis of long noncoding RNA stability. Genome Research 22: 885-898.

* authors contributed equally