Matthew Baker

Senior Lecturer

Dr Matt Baker is a Scientia Research Fellow in the School of Biotechnology and Biomolecular Sciences at the University of New South Wales.

Matt completed his DPhil in Physics at Oxford University as a John Monash Scholar studying the bacterial flagellar motor that makes nearly all bacteria swim. Subsequently Matt investigated protein transport in Oxford's Department of Biochemistry, in particular the bacterial twin arginine transporter (TAT) using cell imaging and artificial bilayer systems. Upon his return to Australia in 2013, Matt focussed primarily on how simple subunit interactions govern assembly of complex architectures, including the rotor (NSMB 2016) and filament (eLife 2017). The next question is how this complexity emerged. To begin addressing this, Matt's nascent group at UNSW looks at how ion selectivity changes using directed evolution (Mol Micro 2019) to examine the evolutionary landscape that constrains the adaptation of the motor.

Matt also investigates force sensitive proteins that change confirmation to activate ion channels (Channels 2019). These are essential at all scales of life, in bacteria to respond to osmotic shock and in mammals in the sense of touch and hearing and are involved in cancer progression and arthritis. This is in collaboration with Prof Boris Martinac of the Victor Chang Cardiac Research Institute and Dr Kate Poole within the School of Medicine at UNSW, and A/Prof Bailong Xiao at Tsinghua University. Matt has been an active delegate and panel chair at the Australia-China Youth Dialogue since 2015, and has active collaborations at Tsinghua, Beida, and SUSTech in Beijing and Shenzhen. In collaboration with Dr Shelley Wickham, we probe membrane dynamics and interactions using novel DNA nanotechnology (Nanoscale 2019), with the ultimate goal to control membrane communication using de novo DNA nanotechnology.

Matt also has a love of radio: he was a Top 5 Under 40 Scientist in Residence at the ABC in 2015 and has continued since then as the regular science presenter on Nightlife, broadcast on ABC Local across Australia, and by producing content for the Health Report, Science Show, Saturday Extra and Earshot on ABC's Radio National. He also has applied his data skills to journalism; he was Australia's inaugural Google Newslab Fellow in 2016 when he was embedded at the Sydney Morning Herald.

 

Journal articles
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Lai YW; Ridone P; Peralta G; Tanaka MM; Baker MAB, 2020, 'Evolution of the stator elements of rotary prokaryote motors', Journal of Bacteriology, vol. 202, http://dx.doi.org/10.1128/JB.00557-19
2020
Baker MAB, 2019, 'ABA/ASB biophysics and medicine session 2018', Biophysical Reviews, vol. 11, pp. 273 - 274, http://dx.doi.org/10.1007/s12551-019-00529-y
2019
Nieves D; Hilzenrat G; Tran J; Yang Z; MacRae H; Baker M; Gooding J; Gaus K, 2019, 'tagPAINT: covalent labelling of genetically encoded protein tags for DNA-PAINT imaging', , http://dx.doi.org/10.1101/604462
2019
Ishida T; Ito R; Clark J; Matzke NJ; Sowa Y; Baker MAB, 2019, 'Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region', Molecular Microbiology, vol. 111, pp. 1689 - 1699, http://dx.doi.org/10.1111/mmi.14246
2019
Baker M; Nieves DJ; Hilzenrat G; Berengut JF; Gaus K; Lee LK, 2019, 'Stoichiometric quantification of spatially dense assemblies with qPAINT', , http://dx.doi.org/10.1101/525345
2019
Baker MAB; Brown AJ, 2019, 'A detour to sterol synthesis', Nature Microbiology, vol. 4, pp. 214 - 215, http://dx.doi.org/10.1038/s41564-018-0347-8
2019
Nieves DJ; Hilzenrat G; Tran J; Yang Z; MacRae HH; Baker MAB; Justin Gooding J; Gaus K, 2019, 'TagPaint: Covalent labelling of genetically encoded protein tags for DNA-PAINT imaging', Royal Society Open Science, vol. 6, pp. 191268, http://dx.doi.org/10.1098/rsos.191268
2019
Jaggers OB; Ridone P; Martinac B; Baker MAB, 2019, 'Fluorescence microscopy of piezo1 in droplet hydrogel bilayers', Channels, vol. 13, pp. 102 - 109, http://dx.doi.org/10.1080/19336950.2019.1586046
2019
Baker MAB; Nieves DJ; Hilzenrat G; Berengut JF; Gaus K; Lee LK, 2019, 'Stoichiometric quantification of spatially dense assemblies with qPAINT', Nanoscale, vol. 11, pp. 12460 - 12464, http://dx.doi.org/10.1039/c9nr00472f
2019
Nichols JA; Herbert Chan HW; Baker MAB, 2018, 'Machine learning: applications of artificial intelligence to imaging and diagnosis.', Biophys Rev, vol. 11, pp. 111 - 118, http://dx.doi.org/10.1007/s12551-018-0449-9
2018
Nieves DJ; Gaus K; Baker MAB, 2018, 'DNA-based super-resolution microscopy: DNA-PAINT', Genes, vol. 9, http://dx.doi.org/10.3390/genes9120621
2018
Ishida T; Ito R; Clark J; Matzke N; Sowa Y; Baker MAB, 2018, 'Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region', , http://dx.doi.org/10.1101/507533
2018
Zhao Z; Zhao Y; Zhuang XY; Lo WC; Baker MAB; Lo CJ; Bai F, 2018, 'Frequent pauses in Escherichia coli flagella elongation revealed by single cell real-Time fluorescence imaging', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-04288-4
2018
Lin G; Baker MAB; Hong M; Jin D, 2018, 'The Quest for Optical Multiplexing in Bio-discoveries', Chem, vol. 4, pp. 997 - 1021, http://dx.doi.org/10.1016/j.chempr.2018.01.009
2018
Jaggers O; Ridone P; Martinac B; Baker M, 2018, 'Fluorescence Microscopy of Piezo1 in Droplet Hydrogel Bilayers', , http://dx.doi.org/10.1101/508176
2018
Baker MAB; Tuckwell AJ; Berengut JF; Bath J; Benn F; Duff AP; Whitten AE; Dunn KE; Hynson RM; Turberfield AJ; Lee LK, 2018, 'Dimensions and Global Twist of Single-Layer DNA Origami Measured by Small-Angle X-ray Scattering', ACS Nano, vol. 12, pp. 5791 - 5799, http://dx.doi.org/10.1021/acsnano.8b01669
2018
Rosholm KR; Baker MAB; Ridone P; Nakayama Y; Rohde PR; Cuello LG; Lee LK; Martinac B, 2017, 'Activation of the mechanosensitive ion channel MscL by mechanical stimulation of supported Droplet-Hydrogel bilayers', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep45180
2017
Chen M; Zhao Z; Yang J; Peng K; Baker MAB; Bai F; Lo CJ, 2017, 'Length-dependent flagellar growth of vibrio alginolyticus revealed by real time fluorescent imaging', eLife, vol. 6, http://dx.doi.org/10.7554/eLife.22140
2017
Alcock F; Stansfeld PJ; Basit H; Habersetzer J; Baker MAB; Palmer T; Wallace MI; Berks BC, 2016, 'Assembling the tat protein translocase', eLife, vol. 5, http://dx.doi.org/10.7554/eLife.20718.001
2016
Pu Y; Zhao Z; Li Y; Zou J; Ma Q; Zhao Y; Ke Y; Zhu Y; Chen H; Baker MAB; Ge H; Sun Y; Xie XS; Bai F, 2016, 'Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells', Molecular Cell, vol. 62, pp. 284 - 294, http://dx.doi.org/10.1016/j.molcel.2016.03.035
2016
Baker MAB; Hynson RMG; Ganuelas LA; Mohammadi NS; Liew CW; Rey AA; Duff AP; Whitten AE; Jeffries CM; Delalez NJ; Morimoto YV; Stock D; Armitage JP; Turberfield AJ; Namba K; Berry RM; Lee LK, 2016, 'Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor', Nature Structural and Molecular Biology, vol. 23, pp. 197 - 203, http://dx.doi.org/10.1038/nsmb.3172
2016
Alcock F; Stansfeld PJ; Basit H; Habersetzer J; Baker MA; Palmer T; Wallace MI; Berks BC, 2016, 'Assembling the Tat protein translocase', eLife, vol. 5, http://dx.doi.org/10.7554/eLife.20718
2016
Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K; Liu D; Lee LK; Böcking T, 2016, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site', Nucleic Acids Research, vol. 44, pp. 1411 - 1420, http://dx.doi.org/10.1093/nar/gkv1466
2016
Ma Q; Sowa Y; Baker MAB; Bai F, 2016, 'Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations', Biophysical Journal, vol. 110, pp. 1411 - 1420, http://dx.doi.org/10.1016/j.bpj.2016.02.023
2016
Xue R; Ma Q; Baker MAB; Bai F, 2015, 'A Delicate Nanoscale Motor Made by Nature—The Bacterial Flagellar Motor', Advanced Science, vol. 2, http://dx.doi.org/10.1002/advs.201500129
2015
Rojko N; Cronin B; Danial JSH; Baker MAB; Anderluh G; Wallace MI, 2014, 'Imaging the lipid-phase-dependent pore formation of equinatoxin II in droplet interface bilayers', Biophysical Journal, vol. 106, pp. 1630 - 1637, http://dx.doi.org/10.1016/j.bpj.2013.11.4507
2014
Baker MAB; Rojko N; Cronin B; Anderluh G; Wallace MI, 2014, 'Photobleaching reveals heterogeneous stoichiometry for equinatoxin II oligomers', ChemBioChem, vol. 16, pp. 2139 - 2145, http://dx.doi.org/10.1002/cbic.201300799
2014
Inoue Y; Baker MAB; Fukuoka H; Takahashi H; Berry RM; Ishijima A, 2013, 'Temperature Dependences of Torque Generation and Membrane Voltage in the Bacterial Flagellar Motor', Biophysical Journal, vol. 105, pp. 2801 - 2810, http://dx.doi.org/10.1016/j.bpj.2013.09.061
2013
Alcock F; Baker MAB; Greene NP; Palmer T; Wallace MI; Berks BC, 2013, 'Live cell imaging shows reversible assembly of the TatA component of the twin-arginine protein transport system.', PNAS, vol. 110, pp. E3650 - E3659, http://dx.doi.org/10.1073/pnas.1306738110
2013
Panchompoo J; Aldous L; Baker M; Wallace MI; Compton RG, 2012, 'One-step synthesis of fluorescein modified nano-carbon for Pd(ii) detection via fluorescence quenching', Analyst, vol. 137, pp. 2054 - 2062, http://dx.doi.org/10.1039/c2an16261j
2012
Baker MAB; Inoue Y; Takeda K; Ishijima A; Berry RM, 2011, 'Two methods of temperature control for single-molecule measurements.', European biophysics journal : EBJ, vol. 40, pp. 651 - 660, http://dx.doi.org/10.1007/s00249-010-0667-y
2011
Baker MAB; Berry RM, 2009, 'An Introduction to the physics of the bacterial flagellar motor: a nanoscale rotary electric motor', Contemporary Physics, vol. 50, pp. 617 - 632, http://dx.doi.org/10.1080/00107510903090553
2009
Carberry DM; Baker MAB; Wang GM; Sevick EM; Evans DJ, 2007, 'An optical trap experiment to demonstrate fluctuation theorems in viscoelastic media', Journal of Optics A: Pure and Applied Optics, vol. 9, pp. 204 - 204
2007
Darley E; Ridone P; Daljit Singh JK; Wickham SFJ; Baker MAB, 'Optimised assembly of DNA-lipid nanostructures', , http://dx.doi.org/10.1101/2020.06.01.128686
Conference Papers
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Hertel S; Liew CW; Baker MA; Lee LK, 2017, 'Artificial assembly of the bacterial flagella motor protein FliG on DNA nanostructures', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, British Biophys Soc, Edinburgh, SCOTLAND, pp. S345 - S345, presented at 19th IUPAB Congress / 11th EBSA Congress, British Biophys Soc, Edinburgh, SCOTLAND, 16 July 2017 - 20 July 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416406202012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2017
Baker MA; Tuckwell AJ; Berengut JF; Bath J; Benn F; Duff AP; Whitten AE; Dunn KE; Hynson RM; Turberfield AJ; Lee LK, 2017, 'DNA origami dimensions and structure measured by solution X-ray scattering', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, British Biophys Soc, Edinburgh, SCOTLAND, pp. S137 - S137, presented at 19th IUPAB Congress / 11th EBSA Congress, British Biophys Soc, Edinburgh, SCOTLAND, 16 July 2017 - 20 July 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416406200296&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2017
Recorded / Rendered Creative Works
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Baker M, 2017, The Full Cost of Fraud, Radio National, ABC, Radio, Published: 04 September 2017, Duration: 00:26:30, Recorded / Rendered Creative Works, http://www.abc.net.au/radionational/programs/earshot/the-full-cost-of-fraud/8805412
2017
Baker MAB; Etherington B, 2016, Roast or Fry: Dancehall in the Yards of Kingston, Radio National, Earshot, Radio, Published: 07 June 2016, Duration: 00:26:30, Recorded / Rendered Creative Works, http://www.abc.net.au/radionational/programs/earshot/roast-or-fry:-dancehall-in-the-yards-of-kingston/7444230
2016
Book Chapters
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Booth TJ; Baker MAB, 2017, 'Nanotechnology: Building and Observing at the Nanometer Scale', in Pharmacognosy: Fundamentals, Applications and Strategy, pp. 633 - 643, http://dx.doi.org/10.1016/B978-0-12-802104-0.00032-9
2017
Baker MAB, 2016, 'How biophysics may help us understand the flagellar motor of bacteria which cause infections', in Biophysics of Infection, pp. 231 - 243, http://dx.doi.org/10.1007/978-3-319-32189-9_14
2016

2018  UNSW Faculty of Science – Dean’s Award for Excellence in Science Communication

2018  Scientia Research Fellowship – UNSW Fellowship

2017  Young 'Tall Poppy' Award, NSW – Australian Instute of Policy and Science

2016  Google News Lab Fellowship – Sole Australian Fellow.

2015  Australia-China Youth Dialogue Delegate

2015  Top 5 Under 40 Winner – ABC/UNSW fellowship to ‘discover Australia’s new generation of science thinkers’

2015  Robert M. Macnab Memorial Travel Award to speak at BLAST XIII in Tucson, Arizona

2009:           Nicholas Kurti Prize for Best 3rd Year DPhil Student Physics, University of Oxford.

2009:           Nesta Famelab UK Finalist (http://www.famelab.org).

2005-2009   John Monash Scholar (http://www.monashawards.org). PhD Fellowship

2001-2004   ANU National Undergraduate Scholarship.

The role of force-sensing ion channels in melanoma migration, NHMRC Project Grant 2017. CIA Poole, CIB Martinac, CIC Biro, CID Baker.

  • Biophysics
  • Bacterial Motility
  • Bacterial Evolution
  • Microscopy
  • Single Molecule
  • Medical Microbiology
  • Antibiotic Microbial Resistance