Megan Lenardon

Senior Lecturer

Dr Lenardon obtained a BSc (Hons) in Microbiology from UNSW in 2000, before going on to complete a PhD in Molecular Genetics in 2005 under the supervision of Prof. Ian Dawes. Megan then moved to the world-renowned Aberdeen Fungal Group (AFG) at the University of Aberdeen in Scotland where she worked as a postdoctoral research fellow with Profs. Neil Gow and Al Brown. During her postdoctoral years, her research focussed on fungal call wall structure and biosynthesis, with a particular interest in the regulation of chitin synthesis during the growth of Candida albicans, as well as the immune recognition of fungal cell wall components, and C. albicans stress responses. She set up her own group in the AFG in 2012 upon the receipt of a New Investigator award from the Medical Research Council (UK), and in 2017, returned to UNSW as a Senior Lecturer in the School of Biotechnology and Biomolecular Sciences.

Dr Lenardon has four research areas in her group - Candida albicans colonisation of the colon, cell wall structure and biosynthesis, cell division and septation in fungi, and antibody-based therapies and diagnostics for fungal infections (see Research Activities). She is the convenor of the Eukaryotic Microbes Special Interest Group of the Australian Society for Microbiology, an editorial board member of The Cell Surface, an Academic Editor for PLoS ONE, and a grant reviewer for the National Health and Medical Research Council (AU), Australian Research Council, Wellcome Trust (UK) and Biotechnology and Biological Sciences Research Council (UK). 

PUBLICATIONS

Journal articles
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Walker L; Sood P; Lenardon MD; Milne G; Olson J; Jensen G; Wolf J; Casadevall A; Adler-Moore J; Gow NAR, 2018, 'The viscoelastic properties of the fungal cell wall allow traffic of ambisome as intact liposome vesicles', mBio, vol. 9, http://dx.doi.org/10.1128/mBio.02383-17
2018
Sherrington SL; Sorsby E; Mahtey N; Kumwenda P; Lenardon MD; Brown I; Ballou ER; MacCallum DM; Hall RA, 2017, 'Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition', PLoS Pathogens, vol. 13, http://dx.doi.org/10.1371/journal.ppat.1006403
2017
Childers DS; Raziunaite I; Mol Avelar G; Mackie J; Budge S; Stead D; Gow NAR; Lenardon MD; Ballou ER; MacCallum DM; Brown AJP, 2016, 'The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence', PLoS Pathogens, vol. 12, http://dx.doi.org/10.1371/journal.ppat.1005566
2016
Preechasuth K; Anderson JC; Peck SC; Brown AJP; Gow NAR; Lenardon MD, 2015, 'Cell wall protection by the Candida albicans class I chitin synthases', Fungal Genetics and Biology, vol. 82, pp. 264 - 276, http://dx.doi.org/10.1016/j.fgb.2015.08.001
2015
Wagener J; Malireddi RKS; Lenardon MD; Köberle M; Vautier S; MacCallum DM; Biedermann T; Schaller M; Netea MG; Kanneganti TD; Brown GD; Brown AJP; Gow NAR, 2014, 'Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation', PLoS Pathogens, vol. 10, http://dx.doi.org/10.1371/journal.ppat.1004050
2014
Hall RA; Bates S; Lenardon MD; MacCallum DM; Wagener J; Lowman DW; Kruppa MD; Williams DL; Odds FC; Brown AJP; Gow NAR, 2013, 'The Mnn2 Mannosyltransferase Family Modulates Mannoprotein Fibril Length, Immune Recognition and Virulence of Candida albicans', PLoS Pathogens, vol. 9, http://dx.doi.org/10.1371/journal.ppat.1003276
2013
Walker LA; Lenardon MD; Preechasuth K; Munro CA; Gow NAR, 2013, 'Cell wall stress induces alternative fungal cytokinesis and septation strategies', Journal of Cell Science, vol. 126, pp. 2668 - 2677, http://dx.doi.org/10.1242/jcs.118885
2013
Lenardon MD; Nantel A, 2012, 'Rapid detection of aneuploidy following the generation of Mutants in Candida albicans', Methods in Molecular Biology, vol. 845, pp. 41 - 49, http://dx.doi.org/10.1007/978-1-61779-539-8_3
2012
You T; Ingram P; Jacobsen MD; Cook E; McDonagh A; Thorne T; Lenardon MD; De Moura AP; Romano MC; Thiel M; Stumpf M; Gow NAR; Haynes K; Grebogi C; Stark J; Brown AJP, 2012, 'A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi', BMC Research Notes, vol. 5, http://dx.doi.org/10.1186/1756-0500-5-258
2012
Kaloriti D; Tillmann A; Cook E; Jacobsen M; You T; Lenardon M; Ames L; Barahona M; Chandrasekaran K; Coghill G; Goodman D; Gow NAR; Grebogi C; Ho HL; Ingram P; McDonagh A; De Moura APS; Pang W; Puttnam M; Radmaneshfar E; Romano MC; Silk D; Stark J; Stumpf M; Thiel M; Thorne T; Usher J; Yin Z; Haynes K; Brown AJP, 2012, 'Combinatorial stresses kill pathogenic Candida species', Medical Mycology, vol. 50, pp. 699 - 709, http://dx.doi.org/10.3109/13693786.2012.672770
2012
Mora-Montes HM; Netea MG; Ferwerda G; Lenardon MD; Brown GD; Mistry AR; Kullberg BJ; O'Callaghan CA; Sheth CC; Odds FC; Brown AJP; Munro CA; Gow NAR, 2011, 'Recognition and blocking of innate immunity cells by Candida albicans chitin', Infection and Immunity, vol. 79, pp. 1961 - 1970, http://dx.doi.org/10.1128/IAI.01282-10
2011
Cheng SC; van de Veerdonk FL; Lenardon M; Stoffels M; Plantinga T; Smeekens S; Rizzetto L; Mukaremera L; Preechasuth K; Cavalieri D; Kanneganti TD; van der Meer JWM; Kullberg BJ; Joosten LAB; Gow NAR; Netea MG, 2011, 'The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans', Journal of Leukocyte Biology, vol. 90, pp. 357 - 366, http://dx.doi.org/10.1189/jlb.1210702
2011
Lenardon MD; Munro CA; Gow NAR, 2010, 'Chitin synthesis and fungal pathogenesis', Current Opinion in Microbiology, vol. 13, pp. 416 - 423, http://dx.doi.org/10.1016/j.mib.2010.05.002
2010
Lenardon MD; Milne SA; Mora-Montes HM; Kaffarnik FAR; Peck SC; Brown AJP; Munro CA; Gow NAR, 2010, 'Phosphorylation regulates polarisation of chitin synthesis in Candida albicans', Journal of Cell Science, vol. 123, pp. 2199 - 2206, http://dx.doi.org/10.1242/jcs.060210
2010
Lenardon MD; Lesiak I; Munro CA; Gow NAR, 2009, 'Dissection of the Candida albicans class i chitin synthase promoters', Molecular Genetics and Genomics, vol. 281, pp. 459 - 471, http://dx.doi.org/10.1007/s00438-009-0423-0
2009
Walker LA; Munro CA; De Bruijn I; Lenardon MD; McKinnon A; Gow NAR, 2008, 'Stimulation of chitin synthesis rescues Candida albicans from echinocandins', PLoS Pathogens, vol. 4, http://dx.doi.org/10.1371/journal.ppat.1000040
2008
Lenardon MD; Whitton RK; Munro CA; Marshall D; Gow NAR, 2007, 'Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall', Molecular Microbiology, vol. 66, pp. 1164 - 1173, http://dx.doi.org/10.1111/j.1365-2958.2007.05990.x
2007
Munro CA; Selvaggini S; De Bruijn I; Walker L; Lenardon MD; Gerssen B; Milne S; Brown AJP; Gow NAR, 2007, 'The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans', Molecular Microbiology, vol. 63, pp. 1399 - 1413, http://dx.doi.org/10.1111/j.1365-2958.2007.05588.x
2007
Conference Papers
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Spyrou M; Brown AJP; Gow NAR; Lenardon MD, 2018, 'Orchestration of chitin synthesis at the septation site of Candida albicans', in MEDICAL MYCOLOGY, OXFORD UNIV PRESS, pp. S157 - S157, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000434852700889&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2018
Wagener J; Malireddi RKS; Lenardon MD; Koberle M; Vautier S; MacCallum DM; Alvarez FJ; Biedermann T; Schaller M; Netea MG; Kanneganti TD; Brown GD; Brown AJP; Gow NAR, 2013, 'Chitin recognition in fungal infections and its impact on the immune response', in GLYCOBIOLOGY, OXFORD UNIV PRESS INC, St Petersburg, FL, pp. 1343 - 1343, presented at Annual Conference of the Society-for-Glycobiology, St Petersburg, FL, 17 November 2013 - 20 November 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326972400050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2013
Book Chapters
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Hall RA; Lenardon MD; Alverez FJ; Nogueira FM; Mukaremera L; Gow NAR, 2013, 'The Candida albicans cell wall: structure and role in morphogenesis and immune recognition', in Mora-Montes HM (ed.), The fungal cell wall, Nova Science Publishers, New York, pp. 1 - 26, https://www.novapublishers.com/catalog/product_info.php?products_id=40080
2013
Conference Abstracts
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Wagener J; Malireddi RKS; Lenardon MD; Koeberle M; Vautier S; MacCallum DM; Biedermann T; Schaller M; Netea MG; Kanneganti T-D; Brown GD; Brown AJP; Gow NAR, 2013, 'Chitin recognition in fungal infections and its impact on the immune response', in MYCOSES, WILEY-BLACKWELL, Vol. 56, pp. 7 - 7, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000322918300023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2013
Preechasuth K; Lenardon MD; Gow NA, 2012, 'Phosphorylation of Chs2 is required for its localization in Candida albicans', in MYCOSES, WILEY-BLACKWELL, Vol. 55, pp. 181 - 181, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305069800567&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2012
Theses / Dissertations
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Lenardon MD, 2006, The role of auxiliary transcription factors in the regulation of gene expression during sporulation in Saccharomyces cerevisiae.
2006