Michael Janitz

Senior Lecturer

SCIENTIFIC INTEREST

Michael has is an internationally recognised expert in the field of transcriptomics, next-generation sequencing technologies and bioinformatics. His current scientific interest focuses on investigations of gene expression and alternative splicing patterns in distinct structures and cell types of the healthy human brain and perturbation of transcriptome profiles during the onset and progression of neurological disorders including multiple system atrophy, epilepsy, amyotrophic lateral sclerosis and chronic fatigue syndrome. Michael is also interested in exploration of cancer-specific alterations in transcriptome profiles towards identification of novel biomarkers such as circular and non-protein coding RNAs.

Professional Experience

  • 2009 - current, Senior Lecturer, School of BABS, UNSW
  • 2000 - 2008 Group Leader, Max Planck Institute for Molecular Genetics, Berlin
  • 1998 -1999 Postdoctoral Fellow, German Centre for Rheumatism Research, Berlin

 

Research contributions

During his PhD studies and subsequently as a postdoc at the German Centre for Rheumatism Research, Michael specialised in investigating the influence of the sequence polymorphism within the promoter regions of MHC class II genes in several inbred mice strains (Janitz et al. 1997; Janitz et al. 1998; Cowell et al. 1998).

Joining the Max Planck Institute for Molecular Genetics (MPIMG) converged with Michael’s growing interest in studying transcription at the genome-wide level. Amongst others, he was involved in collaborative projects to characterise cDNA sequences on the level of the whole transcriptome in mice T helper cells and bovine brain (Gutjahr et al. 2005; Jann et al. 2006), respectively.

While at the MPIMG, Michael and his research group focused on developing a transfected-cell array as a high-throughput genomic tool for functional analysis of genes and their products (Vanhecke and Janitz 2004). This resulted in application of the cell arrays for subcellular protein localisation studies (Hu et al. 2006; Hu et al. 2009; Hu et al. 2010), protein-protein interaction screens (Fiebitz et al. 2008), and functional promoter analysis (Cheng et al. 2010). In addition, with collaborative partners in national and European Community research programs, he applied gene expression profiling studies to identify the genes involved in T helper lymphocytes type 1 immune response (Niesner et al. 2008) and differentiation of murine palatal development (Nogai et al. 2008). His research group also developed miniaturised microarray platforms for DNA hybridization studies using PNA- (Bauer et al. 2004) and LNA-modified oligonucleotide probes (Guerasimova et al. 2006; Liu et al. 2006 and 2007), thus contributing to more efficient exploration of the genome structure and function.

CURRENT RESEARCH

Since his appointment at UNSW Michael has been focused on exploration of different segments of human and mouse transcriptome using combination of Illumina and nanopore DNA and RNA sequencing as well as unique analytical pipeline combining in-house and publicly available bioinformatics tools. He and his team provided first insights into non-protein coding transcriptome of different regions of the human cortex, both in health (Mills et al. 2013; Mills et al. 2015a; Mills et al. 2015b; Bliim et al. 2019) and neurological diseases such as Alzheimer’s disease (Twine et al. 2011; Mills et al. 2013; Mills et al. 2014), multiple system atrophy (MSA)(Mills et al. 2015c; Mills et al. 2016) and epilepsy (Mills et al. 2020) as well as cancer (Takenaka et al. 2016; Chen et al. 2017a). His recent research has been concentrated on circular RNAs (circRNAs) genome-wide expression patterns in the normal human (Chen et al. 2019) and mouse brain (Chen et al. 2018) as well as MSA (Chen et al. 2016) and endometrial cancer (Chen et al. 2017b).

Current research projects aim at understanding of circRNA-miRNA-mRNA networks in epilepsy and amyotrophic lateral sclerosis as well as gynaecological malignancies. Another emerging avenue of Michael’s research is exploration of RNA post-transcriptional modifications in healthy human tissues and cancer using nanopore direct RNA sequencing. Michael’s quest for the discovery of circRNAs, which might serve as molecular biomarker for MSA and endometrial cancer, constitutes another important element of his research program.

COLLABORATIVE PROJECTS

  • Investigation of circular expression patterns in mesial temporal lobe epilepsy; in collaboration with Dr James Mills and Prof. Eleonora Aronica form University of Amsterdam, The Netherland and Prof Orrin Devinsky from New York University Langone Medical Center, U.S.A. 
  • Determination of the transcriptome perturbation in endometrial cancer; in collaboration with A/Prof Kyle Hoehn from School of BABS, UNSW Australia and A/Prof Rhonda Farrell from Prince of Wales Private Hospital Sydney.
  • Investigation of changes in circular transcriptome patterns in amyotrophic lateral sclerosis; in collaboration with Dr Sam Brennan and Dr Matt Keon from GenieUs Genomics Pty Ltd, Sydney, Australia.
  • Investigation of the transcriptome specific for the mouse synaptosome and aging-related alterations in lncRNAs profiles; in collaboration with Prof. Thomas Arendt and Dr. Uwe Ueberham from Paul Flechsig Institute for Brain Research, University of Leipzig, Germany.

 

LABORATORY MEMBERS

  • Ashton Curry-Hyde, PhD candidate
  • Nicola Bliim, PhD candidate
  • Lachlan Gray, MSc candidate
  • Konii Takenaka, MSc candidate
  • Chiara Aquilina-Reid, Industry thesis student
  • Victoria Lin, Honours student
  • Henry Lin, Honours student
  • Celine Tye, Biomolecular Science Laboratory Project (BABS3301) student
  • Si-Mei Xu, Biomolecular Science Laboratory Project (BABS3301) student

 

HONOURS & AWARDS

  • Member of Editorial Board, Genomics (since 2020)
  • Member of Editorial Board, Non-coding RNA (since 2020)
  • Guest Editor, Special Issue Neuroscience Letters (2020)
  • Guest Scientist at Paul Flechsig Institute for Brain Research, University of Leipzig (since 2017)
  • NSW Brain Banks Scientific Review Committee member (since 2017)
  • Member of Editorial Board, Gene (since 2014)
  • Member of Editorial Board - Frontiers in Epigenomics (2011 - 17)
  • Consultant to German Federal Institute for Risk Assessment regarding application of genomic methods as an alternative to animal experiments (2009)
  • Consultant to Gerson Lehrman Group concerning next-generation sequencing technologies and future development perspectives (2007 – 09)
  • Consultant to the German Federal Ministry of Education and Research concerning development of funding schemes in the field of genomic technologies (2007)

 

SELECTED PUBLICATIONS

Mills JD, van Vliet EA, Chen BJ, Janitz M., Anink JJ, Baayen JC, Idema S, Devore S, Friedman D, Diehl B, Thom M, Scott C, Thijs R, Aronica E, Devinsky O (2019) Coding and non-coding transcriptome of mesial temporal lobe epilepsy: Critical role of small non-coding RNAs. Neurobiol Dis 134:104612. Advance online publication.

Chen, Byrne FL, Takenaka K, Modesitt SC, Olzomer EM, Mills JD, Farrell R, Hoehn KL, Janitz, M. (2017) Analysis of the circular RNA transcriptome in endometrial cancer. Oncotarget 9:5786–5796.

Chen BJ, Byrne FL, Takenaka K, Modesitt SC, Olzomer EM, Mills JD, Farrell R, Hoehn KL, Janitz M (2017) Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer. Gynecol Oncol 47:654-662.

Chen BJ, Mills JD, Takenaka K, Bliim N, Halliday GM, Janitz M (2016) Characterization of circular RNAs landscape in multiple system atrophy brain. J Neurochem 139:485-496.

Mills JD, Kavanagh T, Kim WS, Chen BJ, Waters PD, Halliday GM, Janitz M (2015) High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation. Mol Brain 8:2.

Mills JD, Kim WS, Halliday GM, Janitz M (2015) Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy. Neurogenetics 16:107-122.

Twine NA, Janitz K, Wilkins MR, Janitz M (2011) Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease. PLoS One 6:e16266.

Warnatz HJ, Querfurth R, Guerasimova A, Cheng X, Haas SA, Hufton AL, Manke T, Vanhecke D, Nietfeld W, Vingron M, Janitz M, Lehrach H, Yaspo ML (2010) Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. Nucleic Acids Res 38:6112-6123.

Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Haeupl T , Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A (2008) Autoregulation of Th1-mediated inflammation by twist1. J Exp Med 205:1889-1901.

Cowell LG, Kepler TB, Janitz M, Lauster R, Mitchison NA (1998) The distribution of variation in regulatory gene segments, as present in MHC class II promoters. Genome Res 8:124-134.

Journal articles
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Curry-Hyde A; Ueberham U; Arendt T; Janitz M, 2020, 'Neural circular transcriptomes across mammalian species', Genomics, vol. 112, pp. 1162 - 1166, http://dx.doi.org/10.1016/j.ygeno.2019.06.030
2020
Curry-Hyde A; Ueberham U; Jun Chen B; Zipfel I; Mills JD; Bochmann J; Jendrek R; Takenaka K; Kirazov L; Kirazov E; Jünger J; Brückner MK; Arendt T; Janitz M, 2020, 'Analysis of the circular transcriptome in the synaptosomes of aged mice', Neuroscience, http://dx.doi.org/10.1016/j.neuroscience.2020.09.009
2020
Mills JD; van Vliet EA; Chen BJ; Janitz M; Anink JJ; Baayen JC; Idema S; Devore S; Friedman D; Diehl B; Thom M; Scott C; Thijs R; Aronica E; Devinsky O, 2020, 'Coding and non-coding transcriptome of mesial temporal lobe epilepsy: Critical role of small non-coding RNAs', Neurobiology of Disease, vol. 134, pp. 104612, http://dx.doi.org/10.1016/j.nbd.2019.104612
2020
Bliim N; Leshchyns'ka I; Keable R; Chen BJ; Curry-Hyde A; Gray L; Sytnyk V; Janitz M, 2019, 'Early transcriptome changes in response to chemical long-term potentiation induced via activation of synaptic NMDA receptors in mouse hippocampal neurons', Genomics, vol. 111, pp. 1676 - 1686, http://dx.doi.org/10.1016/j.ygeno.2018.11.019
2019
Chen BJ; Huang S; Janitz M, 2019, 'Changes in circular RNA expression patterns during human foetal brain development', Genomics, vol. 111, pp. 753 - 758, http://dx.doi.org/10.1016/j.ygeno.2018.04.015
2019
Stefen H; Suchowerska AK; Chen BJ; Brettle M; Kuschelewski J; Gunning PW; Janitz M; Fath T, 2018, 'Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells', FEBS Open Bio, vol. 8, pp. 570 - 583, http://dx.doi.org/10.1002/2211-5463.12386
2018
Curry-Hyde A; Chen BJ; Ueberham U; Arendt T; Janitz M, 2018, 'Multiple System Atrophy: Many Lessons from the Transcriptome', Neuroscientist, vol. 24, pp. 294 - 307, http://dx.doi.org/10.1177/1073858417723915
2018
Chen BJ; Yang B; Janitz M, 2018, 'Region-specific expression of circular RNAs in the mouse brain', Neuroscience Letters, vol. 666, pp. 44 - 47, http://dx.doi.org/10.1016/j.neulet.2017.12.022
2018
Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, vol. 9, pp. 5786 - 5796, http://dx.doi.org/10.18632/oncotarget.23534
2018
Curry-Hyde A; Chen BJ; Mills JD; Janitz M, 2018, 'Microexons: novel regulators of the transcriptome', Journal of Human Transcriptome, vol. 2, pp. 1 - 6, http://dx.doi.org/10.1080/23324015.2018.1491940
2018
Huang S; Yang B; Chen BJ; Bliim N; Ueberham U; Arendt T; Janitz M, 2017, 'The emerging role of circular RNAs in transcriptome regulation', Genomics, vol. 109, pp. 401 - 407, http://dx.doi.org/10.1016/j.ygeno.2017.06.005
2017
Chen BJ; Ueberham U; Mills JD; Kirazov L; Kirazov E; Knobloch M; Bochmann J; Jendrek R; Takenaka K; Bliim N; Arendt T; Janitz M, 2017, 'RNA sequencing reveals pronounced changes in the noncoding transcriptome of aging synaptosomes', Neurobiology of Aging, vol. 56, pp. 67 - 77, http://dx.doi.org/10.1016/j.neurobiolaging.2017.04.005
2017
Arendt T; Ueberham U; Janitz M, 2017, 'Non-coding transcriptome in brain aging', Aging, vol. 9, pp. 1943 - 1944, http://dx.doi.org/10.18632/aging.101290
2017
Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer', Gynecologic Oncology, vol. 147, pp. 654 - 662, http://dx.doi.org/10.1016/j.ygyno.2017.10.006
2017
Mills JD; Ward M; Kim WS; Halliday GM; Janitz M, 2016, 'Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome', Neuroscience, vol. 322, pp. 234 - 250, http://dx.doi.org/10.1016/j.neuroscience.2016.02.042
2016
Bliim N; Leshchyns’ka I; Sytnyk V; Janitz M, 2016, 'Transcriptional regulation of long-term potentiation', Neurogenetics, vol. 17, pp. 201 - 210, http://dx.doi.org/10.1007/s10048-016-0489-x
2016
Chen BJ; Mills JD; Takenaka K; Bliim N; Halliday GM; Janitz M, 2016, 'Characterization of circular RNAs landscape in multiple system atrophy brain', Journal of Neurochemistry, vol. 139, pp. 485 - 496, http://dx.doi.org/10.1111/jnc.13752
2016
Mills JD; Ward M; Chen BJ; Iyer AM; Aronica E; Janitz M, 2016, 'LINC00507 Is Specifically Expressed in the Primate Cortex and Has Age-Dependent Expression Patterns', Journal of Molecular Neuroscience, vol. 59, pp. 431 - 439, http://dx.doi.org/10.1007/s12031-016-0745-4
2016
Mills JD; Chen BJ; Ueberham U; Arendt T; Janitz M, 2016, 'The Antisense Transcriptome and the Human Brain', Journal of Molecular Neuroscience, vol. 58, pp. 1 - 15, http://dx.doi.org/10.1007/s12031-015-0694-3
2016
Takenaka K; Chen BJ; Modesitt SC; Byrne FL; Hoehn KL; Janitz M, 2016, 'The emerging role of long non-coding RNAs in endometrial cancer', Cancer Genetics, vol. 209, pp. 445 - 455, http://dx.doi.org/10.1016/j.cancergen.2016.09.005
2016
Chen J; Mills JD; Halliday GM; Janitz M, 2015, 'The role of transcriptional control in multiple system atrophy', Neurobiology of Aging, vol. 36, pp. 394 - 400, http://dx.doi.org/10.1016/j.neurobiolaging.2014.08.015
2015
Mills JD; Chen BJ; Ueberham U; Arendt T; Janitz M, 2015, 'The Antisense Transcriptome and the Human Brain', Journal of Molecular Neuroscience, pp. 1 - 15, http://dx.doi.org/10.1007/s12031-015-0694-3
2015
Lourenco GF; Janitz M; Huang Y; Halliday GM, 2015, 'Long noncoding RNAs in TDP-43 and FUS/TLS-related frontotemporal lobar degeneration (FTLD)', Neurobiology of Disease, vol. 82, pp. 445 - 454, http://dx.doi.org/10.1016/j.nbd.2015.07.011
2015
Ward M; McEwan C; Mills JD; Janitz M, 2015, 'Conservation and tissue-specific transcription patterns of long noncoding RNAs.', J Hum Transcr, vol. 1, pp. 2 - 9, http://dx.doi.org/10.3109/23324015.2015.1077591
2015
Mills JD; Kim WS; Halliday GM; Janitz M, 2015, 'Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy', Neurogenetics, vol. 16, pp. 107 - 122, http://dx.doi.org/10.1007/s10048-014-0430-0
2015
Mills JD; Chen J; Kim WS; Waters PD; Prabowo AS; Aronica E; Halliday GM; Janitz M, 2015, 'Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter', Neurogenetics, vol. 16, pp. 201 - 213, http://dx.doi.org/10.1007/s10048-015-0445-1
2015
Mills JD; Kavanagh T; Kim WS; Chen BJ; Waters PD; Halliday GM; Janitz M, 2015, 'High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation', Molecular brain, vol. 8, pp. 2, http://dx.doi.org/10.1186/s13041-014-0091-9
2015
Mills JD; Sheahan PJ; Lai D; Kril JJ; Janitz M; Sutherland GT, 2014, 'The alternative splicing of the apolipoprotein E gene is unperturbed in the brains of Alzheimer’s disease patients', Molecular Biology Reports, vol. 41, pp. 6365 - 6376, http://dx.doi.org/10.1007/s11033-014-3516-8
2014
Mills JD; Kawahara Y; Janitz M, 2013, 'Strand-specific RNA-Seq provides greater resolution of transcriptome profiling', Current Genomics, vol. 14, pp. 173 - 181, http://dx.doi.org/10.2174/1389202911314030003
2013
Mills JD; Kavanagh T; Kim WS; Chen BJ; Kawahara Y; Halliday GM; Janitz M, 2013, 'Unique Transcriptome Patterns of the White and Grey Matter Corroborate Structural and Functional Heterogeneity in the Human Frontal Lobe', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0078480
2013
Mills JD; Nalpathamkalam T; Jacobs HIL; Janitz C; Merico D; Hu P; Janitz M, 2013, 'RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism', Neuroscience Letters, vol. 536, pp. 90 - 95, http://dx.doi.org/10.1016/j.neulet.2012.12.042
2013
Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2013
Twine NA; Janitz C; Wilkins MR; Janitz M, 2013, 'Sequencing of hippocampal and cerebellar transcriptomes provides new insights into the complexity of gene regulation in the human brain.', Neuroscience Letters, vol. 541, pp. 263 - 268, http://dx.doi.org/10.1016/j.neulet.2013.02.034
2013
Kwong R; Lupton M; Janitz M, 2012, 'Single-cell and regional gene expression analysis in Alzheimer's disease.', Cellular and Molecular Neurobiology, vol. 32, pp. 477 - 489, http://dx.doi.org/10.1007/s10571-012-9797-3
2012
Jacobs E; Mills JD; Janitz M, 2012, 'The role of RNA structure in posttranscriptional regulation of gene expression', Journal of Genetics and Genomics, vol. 39, pp. 535 - 543, http://dx.doi.org/10.1016/j.jgg.2012.08.002Document
2012
Janitz K; Janitz M, 2012, 'Moving Towards Third-Generation Sequencing Technologies', Tag-Based Next Generation Sequencing, pp. 323 - 336, http://dx.doi.org/10.1002/9783527644582.ch20
2012
Kavanagh T; Mills JD; Kim WS; Halliday GM; Janitz M, 2012, 'Pathway analysis of the human brain transcriptome in disease', Journal of Molecular Neuroscience, vol. Published online, pp. 28 - 36, http://dx.doi.org/10.1007/s12031-012-9940-0
2012
Mills JD; Janitz M, 2012, 'Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases.', Neurobiology of Aging, vol. 33, pp. 1012.e11 - 1012.e24, http://dx.doi.org/10.1016/j.neurobiolaging.2011.10.030
2012
Twine NA; Janitz K; Wilkins MR; Janitz M, 2011, 'Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease', PLoS One, vol. 6, pp. e16266, http://dx.doi.org/10.1371/journal.pone.0016266
2011
Hu Y; Janitz M, 2011, 'High-throughput subcellular protein localization using transfected-cell arrays', Methods in Molecular Biology, vol. 706, pp. 53 - 72, http://dx.doi.org/10.1007/978-1-61737-970-3_5
2011
Hu Y; Janitz M, 2011, 'High-throughput subcellular protein localization using transfected-cell arrays.', Methods in Molecular Biology, vol. 706, pp. 53 - 72, http://www.ncbi.nlm.nih.gov/pubmed/21104054
2011
Sutherland GT; Janitz M; Kril JJ, 2011, 'Understanding the pathogenesis of Alzheimer's disease: will RNA-Seq realize the promise of transcriptomics?', Journal of Neurochemistry, vol. 116, pp. 937 - 946, http://dx.doi.org/10.1111/j.1471-4159.2010.07157.x
2011
Cheng X; Guerasimova A; Manke T; Rosenstiel P; Haas S; Warnatz HJ; Querfurth R; Nietfeld W; Vanhecke D; Hans L; Yaspo ML; Janitz M, 2010, 'Screening of human gene promoter activities using transfected-cell arrays.', Gene, vol. 450, pp. 48 - 54, http://dx.doi.org/10.1016/j.gene.2009.10.003
2010
Courtney E; Kornfeld S; Janitz K; Janitz M, 2010, 'Transcriptome profiling in neurodegenerative disease', Journal of Neuroscience Methods, vol. 193, pp. 189 - 202, http://dx.doi.org/10.1016/j.jneumeth.2010.08.018
2010
Warnatz HJ; Querfurth R; Guerasimova A; Cheng X; Haas S; Hufton AL; Manke T; Vanhecke D; Nietfeld W; Vingron M; Janitz M; Hans L; Yaspo ML, 2010, 'Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.', Nucleic Acids Research, vol. 38, pp. 6112 - 6123, http://dx.doi.org/10.1093/nar/gkq402
2010
Hu Y; Hans L; Janitz M, 2010, 'Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators.', Molecular Biology Reports, vol. 37, pp. 3381 - 3387, http://dx.doi.org/10.1007/s11033-009-9926-3
2010
Hu Y; Hans L; Janitz M, 2009, 'Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods', Journal of Molecular Histology, vol. 40, pp. 343 - 352, http://dx.doi.org/10.1007/s10735-009-9247-9
2009
Janitz M; Niesner U; Albrecht I; Janke M; Doebis C; Loddenkemper C; Lexberg MH; Eulenburg K; Kreher S; Koeck J; Baumgrass R; Enghard P; Humrich JY; Rutz S; Bonhagen K; Kamradt T, 2008, 'Autoregulation of Th1-mediated inflammation by twist1.', Journal of Experimental Medicine, vol. 205, pp. 1889 - 1901, http://dx.doi.org/10.1084/jem.20072468
2008
Janitz M, 2008, 'Preface', Next Generation Genome Sequencing: Towards Personalized Medicine, http://dx.doi.org/10.1002/9783527625130
2008
Liu JP; Guerasimova A; Schwartz R; Lange M; Lehrach H; Nyársik L; Janitz M, 2006, 'LNA-modified oligodeoxynucleotide hybridization with DNA microarrays printed on nanoporous membrane slides', Combinatorial Chemistry and High Throughput Screening, vol. 9, pp. 591 - 597, http://dx.doi.org/10.2174/138620706778249730
2006
Janitz M; Vanhecke D; Lehrach H, 2006, 'High-throughput RNA interference in functional genomics', Handbook of Experimental Pharmacology, vol. 173, pp. 97 - 104, http://dx.doi.org/10.1007/3-540-27262-3-5
2006
Jann OC; Aerts J; Jones M; Hastings N; Law A; McKay S; Marques E; Prasad A; Yu J; Moore S; Floriot S; Mahé MF; Eggen A; Silveri L; Negrini R; Milanesi E; Ajmone-Marsan P; Valentini A; Marchitelli C; Savarese MC; Janitz M; Herwig R; Hennig S; Gorni C; Connor EE; Sonstegard TS; Smith T; Drögemüller C; Williams JL, 2006, 'A second generation radiation hybrid map to aid the assembly of the bovine genome sequence', BMC Genomics, vol. 7, http://dx.doi.org/10.1186/1471-2164-7-283
2006
Hu YH; Warnatz HJ; Vanhecke D; Wagner F; Fiebitz A; Thamm S; Kahlem P; Lehrach H; Yaspo ML; Janitz M, 2006, 'Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins', BMC Genomics, vol. 7, http://dx.doi.org/10.1186/1471-2164-7-155
2006
Guerasimova A; Nyarsik L; Liu JP; Schwartz R; Lange M; Lehrach H; Janitz M, 2006, 'Liquid-based hybridization assay with real-time detection in miniaturized array platforms', Biomolecular Engineering, vol. 23, pp. 35 - 40, http://dx.doi.org/10.1016/j.bioeng.2005.09.005
2006
Gutjahr C; Murphy D; Lueking A; Koenig A; Janitz M; O'Brien J; Korn B; Horn S; Lehrach H; Cahill DJ, 2005, 'Mouse protein arrays from a TH1 cell cDNA library for antibody screening and serum profiling', Genomics, vol. 85, pp. 285 - 296, http://dx.doi.org/10.1016/j.ygeno.2004.11.005
2005
Vanhecke D; Janitz M; Falter C; Nietfeld W; Lehrach H, 2005, 'Cell arrays - A toll for high-throughput RNA interference studies', BioSpektrum, Supplement, vol. 11, pp. 500 - 502
2005
Vanhecke D; Janitz M, 2005, 'Functional genomics using high-throughput RNA interference', Drug Discovery Today, vol. 10, pp. 205 - 212, http://dx.doi.org/10.1016/S1359-6446(04)03352-5
2005
Hu YH; Vanhecke D; Lehrach H; Janitz M, 2005, 'High-throughput subcellular protein localization using cell arrays', Biochemical Society Transactions, vol. 33, pp. 1407 - 1408, http://dx.doi.org/10.1042/BST20051407
2005
Illiger J; Herwig R; Steinfath M; Przewieslik T; Elge T; Bull C; Radelof U; Lehrach H; Janitz M, 2004, 'Establishment of T cell-specific and natural killer cell-specific unigene sets: Towards high-throughput genomics of leukaemia', European Journal of Immunogenetics, vol. 31, pp. 253 - 257, http://dx.doi.org/10.1111/j.1365-2370.2004.00483.x
2004
Vanhecke D; Janitz M, 2004, 'High-throughput gene silencing using cell arrays', Oncogene, vol. 23, pp. 8353 - 8358, http://dx.doi.org/10.1038/sj.onc.1208027
2004
Bauer O; Guerasimova A; Sauer S; Thamm S; Steinfath M; Herwig R; Janitz M; Lehrach H; Radelof U, 2004, 'Multiplexed hybridizations of positively charge-tagged peptide nucleic acids detected by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry', Rapid Communications in Mass Spectrometry, vol. 18, pp. 1821 - 1829, http://dx.doi.org/10.1002/rcm.1554
2004
Malecová B; Ramser J; O'Brien JK; Janitz M; Júdová J; Lehrach H; Šimúth J, 2003, 'Honeybee (Apis mellifera L.) mrjp gene family: Computational analysis of putative promoters and genomic structure of mrjp1, the gene coding for the most abundant protein of larval food', Gene, vol. 303, pp. 165 - 175, http://dx.doi.org/10.1016/S0378-1119(02)01174-5
2003
Janitz M; Reiners-Schramm L; Muhlethaler-Mottet A; Rosowski M; Lauster R, 2001, 'Analysis of the sequence polymorphism within class II transactivator gene promoters', Experimental and Clinical Immunogenetics, vol. 18, pp. 199 - 205, http://dx.doi.org/10.1159/000049198
2001
Janitz M; Reiners-Schramm L; Lauster R, 1998, 'Expression of the H2-Ea gene is modulated by a polymorphic transcriptional enhancer', Immunogenetics, vol. 48, pp. 266 - 272, http://dx.doi.org/10.1007/s002510050431
1998
Janitz M; Heiser V; Böttcher U; Landt O; Lauster R, 1998, 'Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1', Journal of Molecular Medicine, vol. 76, pp. 141 - 146, http://dx.doi.org/10.1007/s001090050202
1998
Cowell LG; Kepler TB; Janitz M; Lauster R; Mitchison NA, 1998, 'The distribution of variation in regulatory gene segments, as present in MHC class II promoters', Genome Research, vol. 8, pp. 124 - 134, http://dx.doi.org/10.1101/gr.8.2.124
1998
Janitz M; Reiners-Schramm L; Lauster R, 1997, 'Enhancer activity in the 5' untranslated region of the H2-Eb gene', Immunogenetics, vol. 45, pp. 432 - 435, http://dx.doi.org/10.1007/s002510050226
1997
Janitz M; Mitchison A; Reiners-Schramm L; Lauster R, 1997, 'Polymorphic MHC class II promoters exhibit distinct expression pattern in various antigen-presenting cell lines', Tissue Antigens, vol. 49, pp. 99 - 106, http://dx.doi.org/10.1111/j.1399-0039.1997.tb02721.x
1997
Janitz M; Fiszer D; Łukaszyk A; Skorupski W; Kurpisz M, 1995, 'Analysis of mRNA expression for interleukin-1 genes on human testicular cells', Immunology Letters, vol. 48, pp. 139 - 143, http://dx.doi.org/10.1016/0165-2478(95)02458-1
1995
Janitz M; Fiszer D; Michalczak‐Janitz K; Lukaszyk A; Fernandez N; Skorupski W; Kurpisz M, 1994, 'Analysis of mRNA for class I HLA on human gametogenic cells', Molecular Reproduction and Development, vol. 38, pp. 231 - 237, http://dx.doi.org/10.1002/mrd.1080380215
1994
Janitz M; Fiszer D; Jaruzelska J; Simon AK; Biro A; Sachs JA; Kurpisz M, 1993, 'In situ localization of HLA class I mRNA in human testis', Experimental and Clinical Immunogenetics, vol. 10, pp. 202 - 207
1993
Book Chapters
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Grouse L; Curry-Hyde A; Chen BJ; Janitz M, 2019, 'Circular RNAs in Human Health and Disease', in Clinical Epigenetics
2019
Chen BJ; Mills JD; Janitz C; Janitz M, 2016, 'RNA-sequencing to elucidate early patterns of dysregulation underlying the onset of Alzheimer's disease', in Systems Biology of Alzheimer’s Disease, pp. 327 - 347, http://dx.doi.org/10.1007/978-1-4939-2627-5_20
2016
Mills J; Janitz M, 2015, 'Transcriptome profiling in neurodegenerative disorders', in Imaging in Neurodegenerative Disorders, pp. 35 - 41
2015
Janitz C; Janitz M, 2012, 'Moving towards third-generation sequencing technologies', in Handbook of Epigenetics: The new molecular and medical genetics, pp. 325 - 336
2012
Janitz K; Janitz M, 2011, 'Assessing Epigenetic Information', in Tollefsbol T (ed.), Handbook of Epigenetics, Academic Press, pp. 173 - 181, http://dx.doi.org/10.1016/B978-0-12-375709-8.00012-5
2011
Janitz M; Vanhecke D; Lehrach H, 2006, 'High-Throughput RNA Interference in Functional Genomics', in RNA Towards Medicine, pp. 97 - 104
2006
Bauer O; Guerasimova A; Lehrach H; Janitz M, 2003, 'High-Throughput and Industrial Methods for mRNA Expression Analysis', in Analysing Gene Expression: A Handbook of Methods: Possibilities and Pitfalls, pp. 409 - 622
2003
Janitz M; Kurpisz M, 1995, 'Antigens and immunomodulatory factors in spermatogenesis', in Immunology of Human Reproduction, pp. 33 - 52
1995

Research areas: molecular genetics, molecular medicine, genomics and proteomics, molecular biomarkers for neurological disorders and cancer. 

Expertise: Next-generation DNA sequencing technologies, functional genomics, non-coding RNAs, circular RNAs, nanopore sequencing