Professor Nieng Yan

Biography

Dr Nieng Yan received her B.S. degree from the Department of Biological Sciences & Biotechnology, Tsinghua University, Beijing, China, in 2000. She then pursued her PhD in the Department of Molecular Biology at Princeton University under the supervision of Prof. Yigong Shi between 2000 and 2004. She was the regional winner of the Young Scientist Award (North America) co-sponsored by Science/AAAS and GE Healthcare in 2005 for her thesis on the structural and mechanistic study of programmed cell death.

Dr Yan continued her postdoctoral training at Princeton University, focusing on the structural characterization of intramembrane proteases. In 2007, she joined the faculty of School of Medicine, Tsinghua University. Her lab has been mainly focusing on the structural and functional study of membrane transport proteins exemplified by the glucose transporters and Na_v/Ca_vchannels. In 2012 and 2013, she was promoted to tenured professor and Bayer Endowed Chair Professor, respectively.

Dr Yan returned to Princeton University as the founding Shirley M. Tilghman Professor of Molecular Biology in 2017. Dr. Yan was an HHMI international early career scientist in 2012-2017, the recipient of the 2015 Protein Society Young Investigator Award, the 2015 Beverley & Raymond Sackler International Prize in Biophysics, the Alexander M. Cruickshank Award at the GRC on membrane transport proteins in 2016, the 2018 FAOBMB Award for Research Excellence, and the 2019 Weizmann Women & Science Award. She was elected as a Foreign Associate of the US National Academy of Sciences in 2019.

Professor Yan joined the School for Biotechnology and Biomolecular Sciences in the Faculty of Science as a Visiting Professorship under the UNSW SHARP Program in 2019.

Journal articles | 2022

Jiang X; Yan N; Deng D; Yan C, 2022, 'Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect', IUBMB Life, 74, pp. 1180 - 1199, http://dx.doi.org/10.1002/iub.2668

Journal articles | 2022

Wang N; Zhang S; Yuan Y; Xu H; Defossa E; Matter H; Besenius M; Derdau V; Dreyer M; Halland N; He KH; Petry S; Podeschwa M; Tennagels N; Jiang X; Yan N, 2022, 'Molecular basis for inhibiting human glucose transporters by exofacial inhibitors', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-30326-3

Journal articles | 2021

Gao S; Yan N, 2021, 'Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Cav1.1 by Dihydropyridine Compounds**', Angewandte Chemie - International Edition, 60, pp. 3131 - 3137, http://dx.doi.org/10.1002/anie.202011793

Journal articles | 2021

Gong D; Yan N; Ledford HA, 2021, 'Structural Basis for the Modulation of Ryanodine Receptors', Trends in Biochemical Sciences, 46, pp. 489 - 501, http://dx.doi.org/10.1016/j.tibs.2020.11.009

Journal articles | 2021

Huang J; Yuan Y; Zhao N; Pu D; Tang Q; Zhang S; Luo S; Yang X; Wang N; Xiao Y; Zhang T; Liu Z; Sakata-Kato T; Jiang X; Kato N; Yan N; Yin H, 2021, 'Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2017749118

Journal articles | 2021

Li Z; Jin X; Wu T; Huang G; Wu K; Lei J; Pan X; Yan N, 2021, 'Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine**', Angewandte Chemie - International Edition, 60, pp. 11474 - 11480, http://dx.doi.org/10.1002/anie.202102196

Journal articles | 2021

Li Z; Jin X; Wu T; Zhao X; Wang W; Lei J; Pan X; Yan N, 2021, 'Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/PNAS.2100069118

Journal articles | 2021

Pan X; Li Z; Jin X; Zhao Y; Huang G; Huang X; Shen Z; Cao Y; Dong M; Lei J; Yan N, 2021, 'Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/PNAS.2100066118

Journal articles | 2021

Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, 371, http://dx.doi.org/10.1126/science.abb2224

Journal articles | 2020

Gao S; Valinsky WC; On NC; Houlihan PR; Qu Q; Liu L; Pan X; Clapham DE; Yan N, 2020, 'Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc', Proc. Natl. Acad. Sci. U.S.A.

Journal articles | 2020

Jiang X; Yuan Y; Huang J; Zhang S; Luo S; Wang N; Pu D; Zhao N; Tang Q; Hirata K; Yang X; Jiao Y; Sakata-Kato T; Wu JW; Yan C; Kato N; Yin H; Yan N, 2020, 'Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum', Cell, 183, pp. 258 - 268.e12, http://dx.doi.org/10.1016/j.cell.2020.08.015

Journal articles | 2020

Pan Y; Ren Z; Gao S; Shen J; Wang L; Xu Z; Yu Y; Bachina P; Zhang H; Fan X; Laganowsky A; Yan N; Zhou M, 2020, 'Structural basis of ion transport and inhibition in ferroportin', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-19458-6

Journal articles | 2020

Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell

Journal articles | 2020

Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, 581, pp. 333 - 338, http://dx.doi.org/10.1038/s41586-020-2290-0

Journal articles | 2020

Thomas C; Aller SG; Beis K; Carpenter EP; Chang G; Chen L; Dassa E; Dean M; Duong Van Hoa F; Ekiert D; Ford R; Gaudet R; Gong X; Holland IB; Huang Y; Kahne DK; Kato H; Koronakis V; Koth CM; Lee Y; Lewinson O; Lill R; Martinoia E; Murakami S; Pinkett HW; Poolman B; Rosenbaum D; Sarkadi B; Schmitt L; Schneider E; Shi Y; Shyng SL; Slotboom DJ; Tajkhorshid E; Tieleman DP; Ueda K; Váradi A; Wen PC; Yan N; Zhang P; Zheng H; Zimmer J; Tampé R, 2020, 'Structural and functional diversity calls for a new classification of ABC transporters', FEBS Letters, 594, pp. 3767 - 3775, http://dx.doi.org/10.1002/1873-3468.13935

Journal articles | 2020

Wang L; Qian H; Nian Y; Han Y; Ren Z; Zhang H; Hu L; Prasad BVV; Laganowsky A; Yan N; Zhou M, 2020, 'Structure and mechanism of human diacylglycerol O-acyltransferase 1', Nature, 581, pp. 329 - 332

Journal articles | 2020

Yao X; Fan X; Yan N, 2020, 'Cryo-EM analysis of a membrane protein embedded in the liposome', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 18497 - 18503, http://dx.doi.org/10.1073/pnas.2009385117

Journal articles | 2019

Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y

Journal articles | 2019

Jiang X; Wu J; Ke M; Zhang S; Yuan Y; Lin JY; Yan N, 2019, 'Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs', Cell Discov, 5, pp. 14 - 14, http://dx.doi.org/10.1038/s41421-019-0082-1

Journal articles | 2019

Shen H; Liu D; Wu K; Lei J; Yan N, 2019, 'Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins', Science, 363, pp. 1303 - 1308

Journal articles | 2018

Deng D; Yan N, 2018, 'Crystallization and Structural Determination of the Human Glucose Transporters GLUT1 and GLUT3', Methods Mol. Biol., 1713, pp. 15 - 29

Journal articles | 2018

Shen H; Li Z; Jiang Y; Pan X; Wu J; Cristofori-Armstrong B; Smith JJ; Chin YKY; Lei J; Zhou Q; King GF; Yan N, 2018, 'Structural basis for the modulation of voltage-gated sodium channels by animal toxins', Science, 362, http://dx.doi.org/10.1126/science.aau2596

Journal articles | 2018

Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 2018, 'Human SEIPIN Binds Anionic Phospholipids', Dev. Cell, 47, pp. 248 - 256, http://dx.doi.org/10.1016/j.devcel.2018.09.010

Journal articles | 2017

Ke M; Yuan Y; Jiang X; Yan N; Gong H, 2017, 'Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE', PLoS Comput. Biol., 13, pp. e1005603 - e1005603, http://dx.doi.org/10.1371/journal.pcbi.1005603

Journal articles | 2017

Qian H; Zhao X; Cao P; Lei J; Yan N; Gong X, 2017, 'Structure of the Human Lipid Exporter ABCA1', Cell, 169, pp. 1228 - 1239

Journal articles | 2017

Wu J; Yan N; Yan Z, 2017, 'Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex', Adv. Exp. Med. Biol., 981, pp. 23 - 39

Journal articles | 2017

Yan Z; Zhou Q; Wang L; Wu J; Zhao Y; Huang G; Peng W; Shen H; Lei J; Yan N, 2017, 'Structure of the Nav1.4-Î²1 Complex from Electric Eel', Cell, 170, pp. 470 - 482

Journal articles | 2017

Yu X; Yang G; Yan C; Baylon JL; Jiang J; Fan H; Lu G; Hasegawa K; Okumura H; Wang T; Tajkhorshid E; Li S; Yan N, 2017, 'Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters', Cell Res., 27, pp. 1020 - 1033

Journal articles | 2016

Deng D; Yan N, 2016, 'GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters', Protein Sci., 25, pp. 546 - 558

Journal articles | 2016

Gong X; Qian H; Shao W; Li J; Wu J; Liu JJ; Li W; Wang HW; Espenshade P; Yan N, 2016, 'Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization', Cell Res., 26, pp. 1197 - 1211

Journal articles | 2016

Gong X; Qian H; Zhou X; Wu J; Wan T; Cao P; Huang W; Zhao X; Wang X; Wang P; Shi Y; Gao GF; Zhou Q; Yan N, 2016, 'Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection', Cell, 165, pp. 1467 - 1478

Journal articles | 2016

Jiang X; Smirnova I; Kasho V; Wu J; Hirata K; Ke M; Pardon E; Steyaert J; Yan N; Kaback HR, 2016, 'Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation', Proc. Natl. Acad. Sci. U.S.A., 113, pp. 12420 - 12425, http://dx.doi.org/10.1073/pnas.1615414113

Journal articles | 2015

Deng D; Sun P; Yan C; Ke M; Jiang X; Xiong L; Ren W; Hirata K; Yamamoto M; Fan S; Yan N, 2015, 'Molecular basis of ligand recognition and transport by glucose transporters', Nature, 526, pp. 391 - 396, http://dx.doi.org/10.1038/nature14655

Journal articles | 2015

Fern N-C; Yan N; Dionne J; Bassett D; Sebastian S; Hendon C; Schlichting H; Baker M, 2015, 'Hopes for the year ahead', Nature, 517, pp. 111 - 113

Journal articles | 2015

Gong X; Li J; Shao W; Wu J; Qian H; Ren R; Espenshade P; Yan N, 2015, 'Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition', Cell Res., 25, pp. 401 - 411

Journal articles | 2015

Ren R; Zhou X; He Y; Ke M; Wu J; Liu X; Yan C; Wu Y; Gong X; Lei X; Yan SF; Radhakrishnan A; Yan N, 2015, 'Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels', Science, 349, pp. 187 - 191, http://dx.doi.org/10.1126/science.aab1091

Journal articles | 2015

Ren R; Zhou X; He Y; Ke M; Wu J; Liu X; Yan C; Wu Y; Gong X; Lei X; Yan SF; Radhakrishnan A; Yan N, 2015, 'PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels', Science, 349, pp. 187 - 191

Journal articles | 2015

Shen C; Wang X; Liu Y; Li Q; Yang Z; Yan N; Zou T; Yin P, 2015, 'Specific RNA recognition by designer pentatricopeptide repeat protein', Mol Plant, 8, pp. 667 - 670

Journal articles | 2015

Wu J; Yan Z; Li Z; Yan C; Lu S; Dong M; Yan N, 2015, 'Structure of the voltage-gated calcium channel Cav1.1 complex', Science, 350, pp. aad2395 - aad2395

Journal articles | 2015

Yan N, 2015, 'Structural Biology of the Major Facilitator Superfamily Transporters', Annu Rev Biophys, 44, pp. 257 - 283

Journal articles | 2015

Yan Z; Bai X; Yan C; Wu J; Li Z; Xie T; Peng W; Yin C; Li X; Scheres SHW; Shi Y; Yan N, 2015, 'Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution', Nature, 517, pp. 50 - 55

Journal articles | 2014

Deng D; Xu C; Sun P; Wu J; Yan C; Hu M; Yan N, 2014, 'Crystal structure of the human glucose transporter GLUT1', Nature, 510, pp. 121 - 125

Journal articles | 2014

Deng D; Yan C; Wu J; Pan X; Yan N, 2014, 'Revisiting the TALE repeat', Protein Cell, 5, pp. 297 - 306

Journal articles | 2014

He Y; Hao Q; Li W; Yan C; Yan N; Yin P, 2014, 'Identification and characterization of ABA receptors in Oryza sativa', PLoS ONE, 9, pp. e95246 - e95246

Journal articles | 2014

He Y; Wang K; Yan N, 2014, 'The recombinant expression systems for structure determination of eukaryotic membrane proteins', Protein Cell, 5, pp. 658 - 672

Journal articles | 2014

Li Q; Yan C; Xu H; Wang Z; Long J; Li W; Wu J; Yin P; Yan N, 2014, 'Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10)', J. Biol. Chem., 289, pp. 31503 - 31512

Journal articles | 2014

Madej MG; Sun L; Yan N; Kaback HR, 2014, 'Functional architecture of MFS D-glucose transporters', Proc. Natl. Acad. Sci. U.S.A., 111, pp. E719 - 727

Journal articles | 2014

Wang J; Yan C; Li Y; Hirata K; Yamamoto M; Yan N; Hu Q, 2014, 'Crystal structure of a bacterial homologue of SWEET transporters', Cell Res., 24, pp. 1486 - 1489

Journal articles | 2013

Li W; Wang L; Sheng X; Yan C; Zhou R; Hang J; Yin P; Yan N, 2013, 'Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13', Cell Res., 23, pp. 1369 - 1379

Journal articles | 2013

Madej MG; Dang S; Yan N; Kaback HR, 2013, 'Evolutionary mix-and-match with MFS transporters', Proc. Natl. Acad. Sci. U.S.A., 110, pp. 5870 - 5874

Journal articles | 2013

Xia M; Liu H; Li Y; Yan N; Gong H, 2013, 'The mechanism of Naâº/Kâº selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation', Biophys. J., 104, pp. 2401 - 2409

Journal articles | 2013

Yan N, 2013, 'Structural advances for the major facilitator superfamily (MFS) transporters', Trends Biochem. Sci., 38, pp. 151 - 159

Journal articles | 2013

Yan N, 2013, 'Structural investigation of the proton-coupled secondary transporters', Curr. Opin. Struct. Biol., 23, pp. 483 - 491

Journal articles | 2013

Yin P; Li Q; Yan C; Liu Y; Liu J; Yu F; Wang Z; Long J; He J; Wang HW; Wang J; Zhu JK; Shi Y; Yan N, 2013, 'Structural basis for the modular recognition of single-stranded RNA by PPR proteins', Nature, 504, pp. 168 - 171

Journal articles | 2013

Zhang X; Xia M; Li Y; Liu H; Jiang X; Ren W; Wu J; DeCaen P; Yu F; Huang S; He J; Clapham DE; Yan N; Gong H, 2013, 'Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh', Cell Res., 23, pp. 409 - 422, http://dx.doi.org/10.1038/cr.2012.173

Journal articles | 2013

Zhang X; Yan N, 2013, 'The conformational shifts of the voltage sensing domains between Na(v)Rh and Na(v)Ab', Cell Res., 23, pp. 444 - 447

Journal articles | 2012

Deng D; Yan C; Pan X; Mahfouz M; Wang J; Zhu JK; Shi Y; Yan N, 2012, 'Structural basis for sequence-specific recognition of DNA by TAL effectors', Science, 335, pp. 720 - 723

Journal articles | 2012

Deng D; Yin P; Yan C; Pan X; Gong X; Qi S; Xie T; Mahfouz M; Zhu JK; Yan N; Shi Y, 2012, 'Recognition of methylated DNA by TAL effectors', Cell Res., 22, pp. 1502 - 1504

Journal articles | 2012

Sugihara J; Sun L; Yan N; Kaback HR, 2012, 'Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy', Proc. Natl. Acad. Sci. U.S.A., 109, pp. 14847 - 14851

Journal articles | 2012

Sun L; Zeng X; Yan C; Sun X; Gong X; Rao Y; Yan N, 2012, 'Crystal structure of a bacterial homologue of glucose transporters GLUT1-4', Nature, 490, pp. 361 - 366

Journal articles | 2012

Xie T; Ren R; Zhang YY; Pang Y; Yan C; Gong X; He Y; Li W; Miao D; Hao Q; Deng H; Wang Z; Wu JW; Yan N, 2012, 'Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1', J. Biol. Chem., 287, pp. 794 - 802

Journal articles | 2012

Yin P; Deng D; Yan C; Pan X; Xi JJ; Yan N; Shi Y, 2012, 'Specific DNA-RNA hybrid recognition by TAL effectors', Cell Rep, 2, pp. 707 - 713

Journal articles | 2012

Zhang X; Ren W; DeCaen P; Yan C; Tao X; Tang L; Wang J; Hasegawa K; Kumasaka T; He J; Wang J; Clapham DE; Yan N, 2012, 'Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel', Nature, 486, pp. 130 - 134

Journal articles | 2011

Hao Q; Yin P; Li W; Wang L; Yan C; Lin Z; Wu JZ; Wang J; Yan SF; Yan N, 2011, 'The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins', Mol. Cell, 42, pp. 662 - 672

Journal articles | 2011

He W; Brumos J; Li H; Ji Y; Ke M; Gong X; Zeng Q; Li W; Zhang X; An F; Wen X; Li P; Chu J; Sun X; Yan C; Yan N; Xie DY; Raikhel N; Yang Z; Stepanova AN; Alonso JM; Guo H, 2011, 'A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis', Plant Cell, 23, pp. 3944 - 3960

Journal articles | 2011

Lu F; Li S; Jiang Y; Jiang J; Fan H; Lu G; Deng D; Dang S; Zhang X; Wang J; Yan N, 2011, 'Structure and mechanism of the uracil transporter UraA', Nature, 472, pp. 243 - 246

Journal articles | 2010

Dang S; Sun L; Huang Y; Lu F; Liu Y; Gong H; Wang J; Yan N, 2010, 'Structure of a fucose transporter in an outward-open conformation', Nature, 467, pp. 734 - 738

Journal articles | 2010

Hao Q; Yin P; Yan C; Yuan X; Li W; Zhang Z; Liu L; Wang J; Yan N, 2010, 'Functional mechanism of the abscisic acid agonist pyrabactin', J. Biol. Chem., 285, pp. 28946 - 28952

Journal articles | 2010

Qi S; Pang Y; Hu Q; Liu Q; Li H; Zhou Y; He T; Liang Q; Liu Y; Yuan X; Luo G; Li H; Wang J; Yan N; Shi Y, 2010, 'Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4', Cell, 141, pp. 446 - 457

Journal articles | 2010

Yuan X; Yin P; Hao Q; Yan C; Wang J; Yan N, 2010, 'Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2', J. Biol. Chem., 285, pp. 28953 - 28958

Journal articles | 2009

Geng X; Zhou QH; Kage-Nakadai E; Shi Y; Yan N; Mitani S; Xue D, 2009, 'Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells', Cell Death and Differentiation, 16, pp. 1385 - 1394, http://dx.doi.org/10.1038/cdd.2009.88

Journal articles | 2009

Wang Y; Huang Y; Wang J; Cheng C; Huang W; Lu P; Xu YN; Wang P; Yan N; Shi Y, 2009, 'Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel', Nature, 462, pp. 467 - 472

Journal articles | 2009

Yin P; Fan H; Hao Q; Yuan X; Wu D; Pang Y; Yan C; Li W; Wang J; Yan N, 2009, 'Structural insights into the mechanism of abscisic acid signaling by PYL proteins', Nat. Struct. Mol. Biol., 16, pp. 1230 - 1236

Journal articles | 2007

Feng L; Yan H; Wu Z; Yan N; Wang Z; Jeffrey PD; Shi Y, 2007, 'Structure of a site-2 protease family intramembrane metalloprotease', Science, 318, pp. 1608 - 1612

Journal articles | 2007

Yan N; Shi Y, 2007, 'Allosteric activation of a bacterial stress sensor', Cell, 131, pp. 441 - 443

Journal articles | 2006

Wu Z; Yan N; Feng L; Oberstein A; Yan H; Baker RP; Gu L; Jeffrey PD; Urban S; Shi Y, 2006, 'Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry', Nat. Struct. Mol. Biol., 13, pp. 1084 - 1091

Journal articles | 2006

Yan N; Huh JR; Schirf V; Demeler B; Hay BA; Shi Y, 2006, 'Structure and activation mechanism of the Drosophila initiator caspase Dronc', J. Biol. Chem., 281, pp. 8667 - 8674

Journal articles | 2006

Yan N; Xu Y; Shi Y, 2006, '2:1 Stoichiometry of the CED-4-CED-9 complex and the tetrameric CED-4: insights into the regulation of CED-3 activation', Cell Cycle, 5, pp. 31 - 34

Journal articles | 2006

Yang C; Yan N; Parish J; Wang X; Shi Y; Xue D, 2006, 'RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans', J. Biol. Chem., 281, pp. 9137 - 9144

Journal articles | 2005

Yan N; Chai J; Lee ES; Gu L; Liu Q; He J; Wu JW; Kokel D; Li H; Hao Q; Xue D; Shi Y, 2005, 'Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans', Nature, 437, pp. 831 - 837

Journal articles | 2005

Yan N; Shi Y, 2005, 'Mechanisms of apoptosis through structural biology', Annu. Rev. Cell Dev. Biol., 21, pp. 35 - 56

Journal articles | 2004

Feng L; Gell DA; Zhou S; Gu L; Kong Y; Li J; Hu M; Yan N; Lee C; Rich AM; Armstrong RS; Lay PA; Gow AJ; Weiss MJ; Mackay JP; Shi Y, 2004, 'Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin', Cell, 119, pp. 629 - 640, http://dx.doi.org/10.1016/j.cell.2004.11.025

Journal articles | 2004

Huh JR; Vernooy SY; Yu H; Yan N; Shi Y; Guo M; Hay BA, 2004, 'Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization', PLoS Biol., 2, pp. E15 - E15

Journal articles | 2004

La P; Silva AC; Hou Z; Wang H; Schnepp RW; Yan N; Shi Y; Hua X, 2004, 'Direct binding of DNA by tumor suppressor menin', J. Biol. Chem., 279, pp. 49045 - 49054

Journal articles | 2004

Shiozaki EN; Gu L; Yan N; Shi Y, 2004, 'Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling', Mol. Cell, 14, pp. 405 - 412

Journal articles | 2004

Yan N; Gu L; Kokel D; Chai J; Li W; Han A; Chen L; Xue D; Shi Y, 2004, 'Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4', Mol. Cell, 15, pp. 999 - 1006

Journal articles | 2004

Yan N; Wu JW; Chai J; Li W; Shi Y, 2004, 'Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim', Nat. Struct. Mol. Biol., 11, pp. 420 - 428

Journal articles | 2003

Chai J; Wu JW; Yan N; Massagu? J; Pavletich NP; Shi Y, 2003, 'Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding', J. Biol. Chem., 278, pp. 20327 - 20331

Journal articles | 2003

Chai J; Yan N; Huh JR; Wu JW; Li W; Hay BA; Shi Y, 2003, 'Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination', Nat. Struct. Biol., 10, pp. 892 - 898

Journal articles | 2003

Yan N; Shi Y, 2003, 'Histone H1.2 as a trigger for apoptosis', Nat. Struct. Biol., 10, pp. 983 - 985

Journal articles |

Bai XC; Yan Z; Wu J; Li Z; Yan N, 'The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening', Cell Res., 26, pp. 995 - 1006

Journal articles |

Chi X; Gong D; Ren K; Zhou G; Huang G; Lei J; Zhou Q; Yan N, 'Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators', Proc. Natl. Acad. Sci. U.S.A., 116, pp. 25575 - 25582

Journal articles |

Gong D; Chi X; Ren K; Huang G; Zhou G; Yan N; Lei J; Zhou Q, 'Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin', Nat Commun, 9, pp. 3623 - 3623

Journal articles |

Gong D; Chi X; Wei J; Zhou G; Huang G; Zhang L; Wang R; Lei J; Chen SRW; Yan N, 'Modulation of cardiac ryanodine receptor 2 by calmodulin', Nature, 572, pp. 347 - 351

Journal articles |

Gong X; Qian H; Cao P; Zhao X; Zhou Q; Lei J; Yan N, 'Structural basis for the recognition of Sonic Hedgehog by human Patched1', Science, 361

Journal articles |

Han Y; Fan X; Wang H; Zhao F; Tully CG; Kong J; Yao N; Yan N, 'High-yield monolayer graphene grids for near-atomic resolution cryoelectron microscopy', Proc. Natl. Acad. Sci. U.S.A., 117, pp. 1009 - 1014

Journal articles |

Huang W; Liu M; Yan SF; Yan N, 'Structure-based assessment of disease-related mutations in human voltage-gated sodium channels', Protein Cell, 8, pp. 401 - 438

Journal articles |

Liu Y; Hu H; Wang J; Zhou Q; Wu P; Yan N; Wang HW; Wu JW; Sun L, 'Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis', Protein Cell, 10, pp. 365 - 369

Journal articles |

Pan X; Li Z; Huang X; Huang G; Gao S; Shen H; Liu L; Lei J; Yan N, 'Molecular basis for pore blockade of human Na+ channel Nav1.2 by the Î¼-conotoxin KIIIA', Science, 363, pp. 1309 - 1313

Journal articles |

Pan X; Li Z; Zhou Q; Shen H; Wu K; Huang X; Chen J; Zhang J; Zhu X; Lei J; Xiong W; Gong H; Xiao B; Yan N, 'Structure of the human voltage-gated sodium channel Nav1.4 in complex with Î²1', Science, 362

Journal articles |

Peng W; Shen H; Wu J; Guo W; Pan X; Wang R; Chen SR; Yan N, 'Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2', Science, 354

Journal articles |

Qian H; Cao P; Hu M; Gao S; Yan N; Gong X, 'Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm', Nat Commun, 10, pp. 2320 - 2320

Journal articles |

Shen H; Zhou Q; Pan X; Li Z; Wu J; Yan N, 'Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution', Science, 355

Journal articles |

Wu J; Yan Z; Li Z; Qian X; Lu S; Dong M; Zhou Q; Yan N, 'Structure of the voltage-gated calcium channel Ca(v)1.1 at 3.6 Ã… resolution', Nature, 537, pp. 191 - 196

Journal articles |

Yan N, 'A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose Transporters', J. Mol. Biol., 429, pp. 2710 - 2725

Journal articles |

Zhang J; Mao W; Ren Y; Sun RN; Yan N; Gong H, 'Simulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NaVPaS', Protein Cell, 9, pp. 580 - 585

Journal articles |

Zhao Y; Huang G; Wu J; Wu Q; Gao S; Yan Z; Lei J; Yan N, 'Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel', Cell, 177, pp. 1495 - 1506

Journal articles |

Zhao Y; Huang G; Wu Q; Wu K; Li R; Lei J; Pan X; Yan N, 'Cryo-EM structures of apo and antagonist-bound human Cav3.1', Nature, 576, pp. 492 - 497

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