Nieng Yan

Professor

Biography

Dr Nieng Yan received her B.S. degree from the Department of Biological Sciences & Biotechnology, Tsinghua University, Beijing, China, in 2000. She then pursued her PhD in the Department of Molecular Biology at Princeton University under the supervision of Prof. Yigong Shi between 2000 and 2004. She was the regional winner of the Young Scientist Award (North America) co-sponsored by Science/AAAS and GE Healthcare in 2005 for her thesis on the structural and mechanistic study of programmed cell death.

Dr Yan continued her postdoctoral training at Princeton University, focusing on the structural characterization of intramembrane proteases. In 2007, she joined the faculty of School of Medicine, Tsinghua University. Her lab has been mainly focusing on the structural and functional study of membrane transport proteins exemplified by the glucose transporters and Nav/Cavchannels. In 2012 and 2013, she was promoted to tenured professor and Bayer Endowed Chair Professor, respectively.

Dr Yan returned to Princeton University as the founding Shirley M. Tilghman Professor of Molecular Biology in 2017. Dr. Yan was an HHMI international early career scientist in 2012-2017, the recipient of the 2015 Protein Society Young Investigator Award, the 2015 Beverley & Raymond Sackler International Prize in Biophysics, the Alexander M. Cruickshank Award at the GRC on membrane transport proteins in 2016, the 2018 FAOBMB Award for Research Excellence, and the 2019 Weizmann Women & Science Award. She was elected as a Foreign Associate of the US National Academy of Sciences in 2019.

Professor Yan joined the School for Biotechnology and Biomolecular Sciences in the Faculty of Science as a Visiting Professorship under the UNSW SHARP Program in 2019.

PUBLICATIONS

Journal articles
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Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, vol. 581, pp. 333 - 338, http://dx.doi.org/10.1038/s41586-020-2290-0
2020
Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell
2020
Gao S; Valinsky WC; On NC; Houlihan PR; Qu Q; Liu L; Pan X; Clapham DE; Yan N, 2020, 'Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc', Proc. Natl. Acad. Sci. U.S.A.
2020
Wang L; Qian H; Nian Y; Han Y; Ren Z; Zhang H; Hu L; Prasad BVV; Laganowsky A; Yan N; Zhou M, 2020, 'Structure and mechanism of human diacylglycerol O-acyltransferase 1', Nature, vol. 581, pp. 329 - 332
2020
Jiang X; Wu J; Ke M; Zhang S; Yuan Y; Lin JY; Yan N, 2019, 'Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs', Cell Discov, vol. 5, pp. 14 - 14, http://dx.doi.org/10.1038/s41421-019-0082-1
2019
Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, vol. 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y
2019
Shen H; Liu D; Wu K; Lei J; Yan N, 2019, 'Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins', Science, vol. 363, pp. 1303 - 1308
2019
Shen H; Li Z; Jiang Y; Pan X; Wu J; Cristofori-Armstrong B; Smith JJ; Chin YKY; Lei J; Zhou Q; King GF; Yan N, 2018, 'Structural basis for the modulation of voltage-gated sodium channels by animal toxins', Science, vol. 362, http://dx.doi.org/10.1126/science.aau2596
2018
Deng D; Yan N, 2018, 'Crystallization and Structural Determination of the Human Glucose Transporters GLUT1 and GLUT3', Methods Mol. Biol., vol. 1713, pp. 15 - 29
2018
Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 2018, 'Human SEIPIN Binds Anionic Phospholipids', Dev. Cell, vol. 47, pp. 248 - 256, http://dx.doi.org/10.1016/j.devcel.2018.09.010
2018
Ke M; Yuan Y; Jiang X; Yan N; Gong H, 2017, 'Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE', PLoS Comput. Biol., vol. 13, pp. e1005603 - e1005603, http://dx.doi.org/10.1371/journal.pcbi.1005603
2017
Yan Z; Zhou Q; Wang L; Wu J; Zhao Y; Huang G; Peng W; Shen H; Lei J; Yan N, 2017, 'Structure of the Nav1.4-β1 Complex from Electric Eel', Cell, vol. 170, pp. 470 - 482
2017
Yu X; Yang G; Yan C; Baylon JL; Jiang J; Fan H; Lu G; Hasegawa K; Okumura H; Wang T; Tajkhorshid E; Li S; Yan N, 2017, 'Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters', Cell Res., vol. 27, pp. 1020 - 1033
2017
Qian H; Zhao X; Cao P; Lei J; Yan N; Gong X, 2017, 'Structure of the Human Lipid Exporter ABCA1', Cell, vol. 169, pp. 1228 - 1239
2017
Wu J; Yan N; Yan Z, 2017, 'Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex', Adv. Exp. Med. Biol., vol. 981, pp. 23 - 39
2017
Gong X; Qian H; Zhou X; Wu J; Wan T; Cao P; Huang W; Zhao X; Wang X; Wang P; Shi Y; Gao GF; Zhou Q; Yan N, 2016, 'Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection', Cell, vol. 165, pp. 1467 - 1478
2016
Jiang X; Smirnova I; Kasho V; Wu J; Hirata K; Ke M; Pardon E; Steyaert J; Yan N; Kaback HR, 2016, 'Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation', Proc. Natl. Acad. Sci. U.S.A., vol. 113, pp. 12420 - 12425, http://dx.doi.org/10.1073/pnas.1615414113
2016
Deng D; Yan N, 2016, 'GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters', Protein Sci., vol. 25, pp. 546 - 558
2016
Gong X; Qian H; Shao W; Li J; Wu J; Liu JJ; Li W; Wang HW; Espenshade P; Yan N, 2016, 'Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization', Cell Res., vol. 26, pp. 1197 - 1211
2016
Wu J; Yan Z; Li Z; Yan C; Lu S; Dong M; Yan N, 2015, 'Structure of the voltage-gated calcium channel Cav1.1 complex', Science, vol. 350, pp. aad2395 - aad2395
2015
Ren R; Zhou X; He Y; Ke M; Wu J; Liu X; Yan C; Wu Y; Gong X; Lei X; Yan SF; Radhakrishnan A; Yan N, 2015, 'PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels', Science, vol. 349, pp. 187 - 191
2015
Yan N, 2015, 'Structural Biology of the Major Facilitator Superfamily Transporters', Annu Rev Biophys, vol. 44, pp. 257 - 283
2015
Gong X; Li J; Shao W; Wu J; Qian H; Ren R; Espenshade P; Yan N, 2015, 'Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition', Cell Res., vol. 25, pp. 401 - 411
2015
Shen C; Wang X; Liu Y; Li Q; Yang Z; Yan N; Zou T; Yin P, 2015, 'Specific RNA recognition by designer pentatricopeptide repeat protein', Mol Plant, vol. 8, pp. 667 - 670
2015
Fern N-C; Yan N; Dionne J; Bassett D; Sebastian S; Hendon C; Schlichting H; Baker M, 2015, 'Hopes for the year ahead', Nature, vol. 517, pp. 111 - 113
2015
Yan Z; Bai X; Yan C; Wu J; Li Z; Xie T; Peng W; Yin C; Li X; Scheres SHW; Shi Y; Yan N, 2015, 'Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution', Nature, vol. 517, pp. 50 - 55
2015
Deng D; Sun P; Yan C; Ke M; Jiang X; Xiong L; Ren W; Hirata K; Yamamoto M; Fan S; Yan N, 2015, 'Molecular basis of ligand recognition and transport by glucose transporters', Nature, vol. 526, pp. 391 - 396, http://dx.doi.org/10.1038/nature14655
2015
He Y; Hao Q; Li W; Yan C; Yan N; Yin P, 2014, 'Identification and characterization of ABA receptors in Oryza sativa', PLoS ONE, vol. 9, pp. e95246 - e95246
2014
Deng D; Yan C; Wu J; Pan X; Yan N, 2014, 'Revisiting the TALE repeat', Protein Cell, vol. 5, pp. 297 - 306
2014
Madej MG; Sun L; Yan N; Kaback HR, 2014, 'Functional architecture of MFS D-glucose transporters', Proc. Natl. Acad. Sci. U.S.A., vol. 111, pp. E719 - 727
2014
Wang J; Yan C; Li Y; Hirata K; Yamamoto M; Yan N; Hu Q, 2014, 'Crystal structure of a bacterial homologue of SWEET transporters', Cell Res., vol. 24, pp. 1486 - 1489
2014
Li Q; Yan C; Xu H; Wang Z; Long J; Li W; Wu J; Yin P; Yan N, 2014, 'Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10)', J. Biol. Chem., vol. 289, pp. 31503 - 31512
2014
He Y; Wang K; Yan N, 2014, 'The recombinant expression systems for structure determination of eukaryotic membrane proteins', Protein Cell, vol. 5, pp. 658 - 672
2014
Deng D; Xu C; Sun P; Wu J; Yan C; Hu M; Yan N, 2014, 'Crystal structure of the human glucose transporter GLUT1', Nature, vol. 510, pp. 121 - 125
2014
Li W; Wang L; Sheng X; Yan C; Zhou R; Hang J; Yin P; Yan N, 2013, 'Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13', Cell Res., vol. 23, pp. 1369 - 1379
2013
Yin P; Li Q; Yan C; Liu Y; Liu J; Yu F; Wang Z; Long J; He J; Wang HW; Wang J; Zhu JK; Shi Y; Yan N, 2013, 'Structural basis for the modular recognition of single-stranded RNA by PPR proteins', Nature, vol. 504, pp. 168 - 171
2013
Yan N, 2013, 'Structural investigation of the proton-coupled secondary transporters', Curr. Opin. Struct. Biol., vol. 23, pp. 483 - 491
2013
Xia M; Liu H; Li Y; Yan N; Gong H, 2013, 'The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation', Biophys. J., vol. 104, pp. 2401 - 2409
2013
Madej MG; Dang S; Yan N; Kaback HR, 2013, 'Evolutionary mix-and-match with MFS transporters', Proc. Natl. Acad. Sci. U.S.A., vol. 110, pp. 5870 - 5874
2013
Yan N, 2013, 'Structural advances for the major facilitator superfamily (MFS) transporters', Trends Biochem. Sci., vol. 38, pp. 151 - 159
2013
Zhang X; Yan N, 2013, 'The conformational shifts of the voltage sensing domains between Na(v)Rh and Na(v)Ab', Cell Res., vol. 23, pp. 444 - 447
2013
Zhang X; Xia M; Li Y; Liu H; Jiang X; Ren W; Wu J; DeCaen P; Yu F; Huang S; He J; Clapham DE; Yan N; Gong H, 2013, 'Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh', Cell Res., vol. 23, pp. 409 - 422, http://dx.doi.org/10.1038/cr.2012.173
2013
Xie T; Ren R; Zhang YY; Pang Y; Yan C; Gong X; He Y; Li W; Miao D; Hao Q; Deng H; Wang Z; Wu JW; Yan N, 2012, 'Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1', J. Biol. Chem., vol. 287, pp. 794 - 802
2012
Sun L; Zeng X; Yan C; Sun X; Gong X; Rao Y; Yan N, 2012, 'Crystal structure of a bacterial homologue of glucose transporters GLUT1-4', Nature, vol. 490, pp. 361 - 366
2012
Yin P; Deng D; Yan C; Pan X; Xi JJ; Yan N; Shi Y, 2012, 'Specific DNA-RNA hybrid recognition by TAL effectors', Cell Rep, vol. 2, pp. 707 - 713
2012
Deng D; Yin P; Yan C; Pan X; Gong X; Qi S; Xie T; Mahfouz M; Zhu JK; Yan N; Shi Y, 2012, 'Recognition of methylated DNA by TAL effectors', Cell Res., vol. 22, pp. 1502 - 1504
2012
Sugihara J; Sun L; Yan N; Kaback HR, 2012, 'Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy', Proc. Natl. Acad. Sci. U.S.A., vol. 109, pp. 14847 - 14851
2012
Zhang X; Ren W; DeCaen P; Yan C; Tao X; Tang L; Wang J; Hasegawa K; Kumasaka T; He J; Wang J; Clapham DE; Yan N, 2012, 'Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel', Nature, vol. 486, pp. 130 - 134
2012
Deng D; Yan C; Pan X; Mahfouz M; Wang J; Zhu JK; Shi Y; Yan N, 2012, 'Structural basis for sequence-specific recognition of DNA by TAL effectors', Science, vol. 335, pp. 720 - 723
2012
He W; Brumos J; Li H; Ji Y; Ke M; Gong X; Zeng Q; Li W; Zhang X; An F; Wen X; Li P; Chu J; Sun X; Yan C; Yan N; Xie DY; Raikhel N; Yang Z; Stepanova AN; Alonso JM; Guo H, 2011, 'A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis', Plant Cell, vol. 23, pp. 3944 - 3960
2011
Hao Q; Yin P; Li W; Wang L; Yan C; Lin Z; Wu JZ; Wang J; Yan SF; Yan N, 2011, 'The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins', Mol. Cell, vol. 42, pp. 662 - 672
2011
Lu F; Li S; Jiang Y; Jiang J; Fan H; Lu G; Deng D; Dang S; Zhang X; Wang J; Yan N, 2011, 'Structure and mechanism of the uracil transporter UraA', Nature, vol. 472, pp. 243 - 246
2011
Dang S; Sun L; Huang Y; Lu F; Liu Y; Gong H; Wang J; Yan N, 2010, 'Structure of a fucose transporter in an outward-open conformation', Nature, vol. 467, pp. 734 - 738
2010
Yuan X; Yin P; Hao Q; Yan C; Wang J; Yan N, 2010, 'Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2', J. Biol. Chem., vol. 285, pp. 28953 - 28958
2010
Hao Q; Yin P; Yan C; Yuan X; Li W; Zhang Z; Liu L; Wang J; Yan N, 2010, 'Functional mechanism of the abscisic acid agonist pyrabactin', J. Biol. Chem., vol. 285, pp. 28946 - 28952
2010
Qi S; Pang Y; Hu Q; Liu Q; Li H; Zhou Y; He T; Liang Q; Liu Y; Yuan X; Luo G; Li H; Wang J; Yan N; Shi Y, 2010, 'Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4', Cell, vol. 141, pp. 446 - 457
2010
Wang Y; Huang Y; Wang J; Cheng C; Huang W; Lu P; Xu YN; Wang P; Yan N; Shi Y, 2009, 'Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel', Nature, vol. 462, pp. 467 - 472
2009
Yin P; Fan H; Hao Q; Yuan X; Wu D; Pang Y; Yan C; Li W; Wang J; Yan N, 2009, 'Structural insights into the mechanism of abscisic acid signaling by PYL proteins', Nat. Struct. Mol. Biol., vol. 16, pp. 1230 - 1236
2009
Feng L; Yan H; Wu Z; Yan N; Wang Z; Jeffrey PD; Shi Y, 2007, 'Structure of a site-2 protease family intramembrane metalloprotease', Science, vol. 318, pp. 1608 - 1612
2007
Yan N; Shi Y, 2007, 'Allosteric activation of a bacterial stress sensor', Cell, vol. 131, pp. 441 - 443
2007
Wu Z; Yan N; Feng L; Oberstein A; Yan H; Baker RP; Gu L; Jeffrey PD; Urban S; Shi Y, 2006, 'Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry', Nat. Struct. Mol. Biol., vol. 13, pp. 1084 - 1091
2006
Yang C; Yan N; Parish J; Wang X; Shi Y; Xue D, 2006, 'RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans', J. Biol. Chem., vol. 281, pp. 9137 - 9144
2006
Yan N; Huh JR; Schirf V; Demeler B; Hay BA; Shi Y, 2006, 'Structure and activation mechanism of the Drosophila initiator caspase Dronc', J. Biol. Chem., vol. 281, pp. 8667 - 8674
2006
Yan N; Xu Y; Shi Y, 2006, '2:1 Stoichiometry of the CED-4-CED-9 complex and the tetrameric CED-4: insights into the regulation of CED-3 activation', Cell Cycle, vol. 5, pp. 31 - 34
2006
Yan N; Shi Y, 2005, 'Mechanisms of apoptosis through structural biology', Annu. Rev. Cell Dev. Biol., vol. 21, pp. 35 - 56
2005
Yan N; Chai J; Lee ES; Gu L; Liu Q; He J; Wu JW; Kokel D; Li H; Hao Q; Xue D; Shi Y, 2005, 'Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans', Nature, vol. 437, pp. 831 - 837
2005
Yan N; Gu L; Kokel D; Chai J; Li W; Han A; Chen L; Xue D; Shi Y, 2004, 'Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4', Mol. Cell, vol. 15, pp. 999 - 1006
2004
La P; Silva AC; Hou Z; Wang H; Schnepp RW; Yan N; Shi Y; Hua X, 2004, 'Direct binding of DNA by tumor suppressor menin', J. Biol. Chem., vol. 279, pp. 49045 - 49054
2004
Shiozaki EN; Gu L; Yan N; Shi Y, 2004, 'Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling', Mol. Cell, vol. 14, pp. 405 - 412
2004
Yan N; Wu JW; Chai J; Li W; Shi Y, 2004, 'Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim', Nat. Struct. Mol. Biol., vol. 11, pp. 420 - 428
2004
Huh JR; Vernooy SY; Yu H; Yan N; Shi Y; Guo M; Hay BA, 2004, 'Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization', PLoS Biol., vol. 2, pp. E15 - E15
2004
Feng L; Gell DA; Zhou S; Gu L; Kong Y; Li J; Hu M; Yan N; Lee C; Rich AM; Armstrong RS; Lay PA; Gow AJ; Weiss MJ; Mackay JP; Shi Y, 2004, 'Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin', Cell, vol. 119, pp. 629 - 640, http://dx.doi.org/10.1016/j.cell.2004.11.025
2004
Yan N; Shi Y, 2003, 'Histone H1.2 as a trigger for apoptosis', Nat. Struct. Biol., vol. 10, pp. 983 - 985
2003
Chai J; Yan N; Huh JR; Wu JW; Li W; Hay BA; Shi Y, 2003, 'Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination', Nat. Struct. Biol., vol. 10, pp. 892 - 898
2003
Chai J; Wu JW; Yan N; Massagu? J; Pavletich NP; Shi Y, 2003, 'Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding', J. Biol. Chem., vol. 278, pp. 20327 - 20331
2003
Gong D; Chi X; Ren K; Huang G; Zhou G; Yan N; Lei J; Zhou Q, 'Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin', Nat Commun, vol. 9, pp. 3623 - 3623
Pan X; Li Z; Zhou Q; Shen H; Wu K; Huang X; Chen J; Zhang J; Zhu X; Lei J; Xiong W; Gong H; Xiao B; Yan N, 'Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1', Science, vol. 362
Gong X; Qian H; Cao P; Zhao X; Zhou Q; Lei J; Yan N, 'Structural basis for the recognition of Sonic Hedgehog by human Patched1', Science, vol. 361
Zhang J; Mao W; Ren Y; Sun RN; Yan N; Gong H, 'Simulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NaVPaS', Protein Cell, vol. 9, pp. 580 - 585
Yan N, 'A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose Transporters', J. Mol. Biol., vol. 429, pp. 2710 - 2725
Han Y; Fan X; Wang H; Zhao F; Tully CG; Kong J; Yao N; Yan N, 'High-yield monolayer graphene grids for near-atomic resolution cryoelectron microscopy', Proc. Natl. Acad. Sci. U.S.A., vol. 117, pp. 1009 - 1014
Chi X; Gong D; Ren K; Zhou G; Huang G; Lei J; Zhou Q; Yan N, 'Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators', Proc. Natl. Acad. Sci. U.S.A., vol. 116, pp. 25575 - 25582
Shen H; Zhou Q; Pan X; Li Z; Wu J; Yan N, 'Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution', Science, vol. 355
Zhao Y; Huang G; Wu Q; Wu K; Li R; Lei J; Pan X; Yan N, 'Cryo-EM structures of apo and antagonist-bound human Cav3.1', Nature, vol. 576, pp. 492 - 497
Huang W; Liu M; Yan SF; Yan N, 'Structure-based assessment of disease-related mutations in human voltage-gated sodium channels', Protein Cell, vol. 8, pp. 401 - 438
Gong D; Chi X; Wei J; Zhou G; Huang G; Zhang L; Wang R; Lei J; Chen SRW; Yan N, 'Modulation of cardiac ryanodine receptor 2 by calmodulin', Nature, vol. 572, pp. 347 - 351
Zhao Y; Huang G; Wu J; Wu Q; Gao S; Yan Z; Lei J; Yan N, 'Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel', Cell, vol. 177, pp. 1495 - 1506
Qian H; Cao P; Hu M; Gao S; Yan N; Gong X, 'Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm', Nat Commun, vol. 10, pp. 2320 - 2320
Peng W; Shen H; Wu J; Guo W; Pan X; Wang R; Chen SR; Yan N, 'Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2', Science, vol. 354
Wu J; Yan Z; Li Z; Qian X; Lu S; Dong M; Zhou Q; Yan N, 'Structure of the voltage-gated calcium channel Ca(v)1.1 at 3.6 Ã… resolution', Nature, vol. 537, pp. 191 - 196
Pan X; Li Z; Huang X; Huang G; Gao S; Shen H; Liu L; Lei J; Yan N, 'Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA', Science, vol. 363, pp. 1309 - 1313
Liu Y; Hu H; Wang J; Zhou Q; Wu P; Yan N; Wang HW; Wu JW; Sun L, 'Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis', Protein Cell, vol. 10, pp. 365 - 369
Bai XC; Yan Z; Wu J; Li Z; Yan N, 'The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening', Cell Res., vol. 26, pp. 995 - 1006