Endogenous and Artificial Modulators of Cell Adhesion

Cell adhesion molecules are cell surface glycoproteins, the function of which is regulated by neurons at different stages of brain development and in response to a variety of external stimuli, for example during learning.

This project will aim to identify and characterise new endogenous regulators of cell adhesion molecules and test artificial regulators of cell adhesion molecules to analyse their pharmacological potential in various disease models.Recombinant protein production, mass spectrometry, protein-protein interaction assays, various protein analysis tools, and cellular models will be used.

References:

  • Chernyshova Y, Leshchyns'ka I, Hsu SC, Schachner M & Sytnyk V, 2011, ‘The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones’, Journal of Neuroscience, 31:3522-35.
  • Sheng L, Leshchyns'ka I, & Sytnyk V, 2015, ’Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels’, Journal of Neuroscience, 35:1739-52.
  • Puchkov D, Leshchyns'ka I, Nikonenko AG, Schachner M & Sytnyk V, 2011, ‘NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation’, Cerebral Cortex, 21:2217-32.
  • Sytnyk V, Leshchyns'ka I & Schachner M., 2017, ‘Neural cell adhesion molecules of the Immunoglobulin superfamily regulate synapse formation, maintenance, and function’, Trends in Neuroscience, 40:295-308.
  • Sheng L, Leshchyns'ka I, & Sytnyk V, 2015, ’Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels’, Journal of Neuroscience, 35:1739-52

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