Engineering the Next Generation of Artificial Transcription Factors

In the Crossley lab, we study how transcription factors control cell fate and how the breakdown of this process leads to disease. We apply this knowledge with the ultimate aim of reprogramming cells to treat cancer, blood diseases and metabolic disorders. 

The ability to artificially regulate gene expression offers immense promise for the treatment of human diseases. In this project, we will apply knowledge of how natural transcription factors regulate their target genes to engineer a new generation of more potent artificial factors.

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