Evolution Across Interfaces

In this project we explore the directed evolution of the flagellar motor in the lab by evolving it to swim under different energy sources and selecting for motility. Recent work in antibiotic resistance by Michael Baym has shown that the resistance of antibiotics occurs in lockstep when progressing through 10-fold increases in antibiotics.

We aim to explore how motility can evolve across interfaces, when a bacterium faces a change in environment between, for example, H+ and Na+ environments, and how the bacteria adapts to dwindling nutrient across this interface.

This project has scope for designing and building custom tanks to optimise bacterial evolution using 3D printing and prototyping, as well as investigating microbiology and bacterial motility in multiple dimensions using layered swim devices.

We are recruiting for Honours and PhD students commencing in 2018.

BABS academic responsible for this project:

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