Evolution of Antibiotic Resistance in S. Typhimurium

Project on Salmonella enterica serovar Typhimurium
Salmonella enterica is a zoonotic pathogen causing a variety of diseases in humans and animals. S. Typhimurium represents up to 50% of human and 20-25% of bovine and chicken isolates in Australia, posing a major public health threat.

Multidrug-resistant (MDR) Salmonella has been reported in human infections and food animals in many countries. Recent studies showed that although the majority of the isolates from Australia remain susceptible to all antimicrobials, MDR S. Typhimurium isolates have been detected in food animals. Our analysis of a set of S. Typhimurium isolates identified that 6 lineages gained multidrug resistance to 4 to 13 antibiotics. This project will elucidate the genetic basis of the resistance of these isolates. The project involves genome sequencing, molecular biology techniques and bioinformatics analysis.

Recent publications

  • Lam C et al, 2014, ‘Rapid increase in pertactin-deficient Bordetella pertussis isolates, Australia’, Emerg Infect Dis. 20:626.
  • Bart M et al, 2014, ‘Global population structure and evolution of Bordetella pertussis and their relationship with vaccination’, MBio, 5: e01074.
  • Octavia S, 2015, Delineating community outbreaks of Salmonella enterica serovar Typhimurium by use of whole-genome sequencing: insights into genomic variability within an outbreak’, J Clin Microbiol, 53:1063.
  • Fu S et al, 2015, ‘Defining the core genome of Salmonella enterica serovar typhimurium for genomic surveillance and epidemiological typing’, J Clin Microbiol, 53:2530. 

BABS academic responsible for this project:

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