Evolution of Mammal Sex Chromosomes

In order to understand the intricacies of X and Y chromosome evolution, we investigate Y chromosome gene content and structure in our model marsupial, the tammar wallaby (Macropus eugenii ). Using gene-specific and whole Y chromosome probes to screen BAC libraries, we have identified novel genes on the wallaby Y.

Many of these genes are also conserved on the Y in other Australian (Tasmanian devil) and American (opossum) marsupials, but lost from the Y in placental mammals.

This project will focus on characterising genes on the Tasmanian Devil Y chromosome, not only helping to understand mammal Y chromosomes, but also the X.

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