Identifying New Drug Targets for the Treatment of Obesity-related Cancers

Genetic analysis studies recently performed by our collaborators within BABS have identified several protein-coding and non-coding genes that are abnormally expressed in cancer tissue compared to non-cancer tissue. Some genes have been linked to other types of cancer, while others are completely new and we have no idea what they do or why they are alternately regulated in cancer.

Projects for Honours students will involve validating differentially expressed genes by qPCR and determining their functional significance in cell growth and survival by knocking down or over-expressing the genes in cancer cells and non-cancer cells. Genes that facilitate cancer cell growth or survival represent potential new drug targets for anti-cancer therapy.

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