The Impact of Toxins Encoded by Campylobacter Concisus Mobile Elements on the Intestinal Barrier and the Gut Mucosal Immune System

Campylobacter concisus is an oral bacterium that is associated with IBD. We have found that IBD associated C. concisus strains have acquired virulence genes from mobile elements such as plasmids and prophages. We are currently examining the effects of the toxins encoded by C. concisus mobile elements on the gut immune system and intestinal epithelial barrier function.

Two Honours projects are available under this research topic. Techniques used in these projects include cell culture, confocal microscopy, flow cytometry, Western-blot, protein sequencing, ELISA, small animal handling, bacterial gene knockout and bacterial cultivation.

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