Influence of Diet on Parkinsonism

While drugs to treat the symptoms of Parkinsonism have been prescribed for decades, an unmet need remains for innovative strategies that either halt or reverse progression. Indeed, the management of Parkinsonism lags behind other major diseases of our society, such as cardiovascular disease. We employ parkin mutant Drosophila and human fibroblast cells to test the influence of the protein:carbohydrate ratio on mitochondrial functions, as we have shown this ratio influences mitochondrial functions in Drosophila and mice.

We target mitochondrial function because there is strong corroborative evidence that the disease is linked to organelle dysfunction.

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