Inheritance of Mitochondrial DNA

The central role of animal mtDNA in molecular ecology, and in medicine, has highlighted its critical importance in life sciences. Mutations in mtDNA are often used to infer genetic relationships and have been associated with the expression of human diseases. A surprising gap in our knowledge base is a mechanistic understanding of the processes involved in mtDNA inheritance.

We aim to put currently accepted models of mtDNA inheritance to stringent tests. This project examines the exact mechanism of inheritance of mitochondrial genes to enhance biological interpretations and our understanding of the heritability of specific diseases.

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