Mechanisms of the Neuronal Network Development

During formation of neuronal networks, neurons must grow long axons to make synapses on other neurons. Neurons must also develop extensively branched dendrites to receive synapses from other neurons. Neural cell adhesion molecules are found at the growing tips of axons and dendrites (the image on the right), and regulate the speed and direction of their growth. The project will analyse how growth and recognition between neurons are affected by altered levels of the cell adhesion molecule NCAM2. Neurons and model cells will be used to analyse biochemical pathways regulated by NCAM2 during neuronal development.

The results of this work will help to understand why deficiency or increased levels of NCAM2 cause neurodevelopmental disorders.

References:

  • Chernyshova Y, Leshchyns'ka I, Hsu SC, Schachner M & Sytnyk V, 2011, ‘The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones’, Journal of Neuroscience, 31:3522-35.
  • Sheng L, Leshchyns'ka I, & Sytnyk V, 2015, ’Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels’, Journal of Neuroscience, 35:1739-52.
  • Puchkov D, Leshchyns'ka I, Nikonenko AG, Schachner M & Sytnyk V, 2011, ‘NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation’, Cerebral Cortex, 21:2217-32.
  • Sytnyk V, Leshchyns'ka I & Schachner M., 2017, ‘Neural cell adhesion molecules of the Immunoglobulin superfamily regulate synapse formation, maintenance, and function’, Trends in Neuroscience, 40:295-308.
  • Sheng L, Leshchyns'ka I, & Sytnyk V, 2015, ’Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels’, Journal of Neuroscience, 35:1739-52.

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