Projects on Helicobacter pylori

H. pylori has been causally linked to the development of gastritis, peptic ulcer disease (PUD) and gastric cancer (GC). Although 50% of the world’s population is infected with H. pylori, only a small percentage develops PUD (10-15%), GC (1-3%) and B cell MALT lymphoma (<1%). These outcomes suggest that factors other than bacterial infection (environmental risk and host genetic susceptibility) may contribute to more serious disease outcomes. We are interested in the role of host genetic polymorphisms in genes involved in innate immunity.

  • Project: To investigate the role of autophagy in H. pylori related gastric cancer.

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