Projects on Inflammatory Bowel Disease

IBD is a chronic relapsing idiopathic inflammatory disease of the gastrointestinal tract, whose cause remains unclear. It is hypothesised that an initiator, believed to be either gastrointestinal microorganisms or their by-products in association with a disruption of the gastrointestinal epithelium, stimulates and subsequently drives a dysregulated immune response in genetically predisposed individuals. We have recently investigated the effect of FMT in patients with UC and have identified a number of bacterial species that are significantly associated with either clinical remission or lack of remission.

Projects involve a range of cutting-edge technologies, including high-throughput sequencing, genome editing, bacterial community analyses, real-time PCR, mass spectrometry, electron microscopy, confocal microscopy as well as more basic techniques such as cell culture, ELISA, Western blotting, PCR and 2D gel electrophoresis are employed in the projects. 

  • Project 1:  To quantitate the abundance of specific bacterial species that have been significantly associated with either clinical remission or lack of remission in faecal and biopsy samples of UC patients who underwent FMT.
  • Project 2: To investigate in children and young adults presenting with IBD the influence of H. pylori infection on the gastrointestinal microbiota.
    

BABS academic responsible for this project:

Currently Active: 
Yes