Recombinant reductive dehalogenases

Reductive dehalogenases are enzymes involved in the reductive dechlorination of polychlorinated hydrocarbons, such as hexachlorobenzene. Microbial processes to degrade hexachlorobenzene and other chlorinated hydrocarbons have been described, however, the anaerobic processes in particular are relatively slow, because of low cell densities, slow growth rates and low substrate concentrations.

This project will continue work on recombinant expression of TmrA; a reductive dehalogenase capable of dechlorinating chloroform. Experiments will include improving the current process and continuing work on refolding recombinant TmrA expressed in a variety of hosts.

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