Searching for the Protein Interaction Code

We have recently developed a new system (the conditional two-hybrid system) to test whether interactions of proteins are modulated by modifications such as methylation and phosphorylation (Erce et al. 2013). We are now starting to look at ‘hub proteins’, those with many interaction partners but only 1 or 2 interaction interfaces, to see whether the cell uses combinations of protein modifications to control the specificity of interactions. This project will investigate one or more hub proteins for the presence of an interaction code. This will be a lot of fun.

Reference: Erce MA, Abeygunawardena D, Low JK, Hart-Smith G & Wilkins MR, 2013, ‘Interactions affected by arginine methylation in the yeast protein-protein interaction network’, Molecular & Cellular Proteomics, 12(11): 3184-98.

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