Synaptic Mechanisms of Memory Formation and Maintenance in Health and Disease

Synapses (image on the left) are formed during development and their numbers and function are regulated during learning. This project will investigate molecular mechanisms of synapse remodelling and the role the neural cell adhesion molecules (NCAM2, L1, or NEGR1) play in formation, maintenance and regulation of numbers of synapses and neurotransmission efficiency. Cellular and animal models of learning and brain disorders associated with synapse loss, e.g. Alzheimer’s disease, will be used.

This analysis will help to understand why abnormal function of these molecules causes intellectual disability.

References:

  • Chernyshova Y, Leshchyns'ka I, Hsu SC, Schachner M & Sytnyk V, 2011, ‘The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones’, Journal of Neuroscience, 31:3522-35.
  • Sheng L, Leshchyns'ka I, & Sytnyk V, 2015, ’Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels’, Journal of Neuroscience, 35:1739-52.
  • Puchkov D, Leshchyns'ka I, Nikonenko AG, Schachner M & Sytnyk V, 2011, ‘NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation’, Cerebral Cortex, 21:2217-32.
  • Sytnyk V, Leshchyns'ka I & Schachner M., 2017, ‘Neural cell adhesion molecules of the Immunoglobulin superfamily regulate synapse formation, maintenance, and function’, Trends in Neuroscience, 40:295-308.
  • Sheng L, Leshchyns'ka I, & Sytnyk V, 2015, ’Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels’, Journal of Neuroscience, 35:1739-52

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