Tailorable Protein Scaffolds for Nanomedicine

The folding and assembly of proteins into intricate supramolecular architectures is critical to many biological functions, ranging from cellular scaffolding provided by cytoskeletal proteins to the encapsulation of nucleic acids in viral capsids. Improvements in our understanding of protein assembly is enabling the creation of biomaterials that mimic and complement biological systems. The research projects in my laboratory use synthetic biology to build functional nanoscale materials and devices from self-assembling proteins.

Biomaterials play a central role in regenerative medicine and tissue engineering strategies, where they serve as tuneable biophysical and biochemical environments that direct cellular behaviour and function to replace and regenerate missing or injured tissue. Improvements in our understanding of protein assembly is enabling the creation of protein-based biomaterials that can interface and control biological systems. This project will combine the fields of biology and engineering to fabricate novel protein scaffolds with tuneable biophysical and biochemical features. This will permit scaffolds to be created with desirable properties to direct cell adhesion, proliferation, infiltration and scaffold remodelling.

BABS academic responsible for this project:

Currently Active: 
Yes