Virus Projects: Examining Cellular Changes; Transfer of Virus Material to Neighbouring Cells

Our lab has demonstrated the presence of three viruses, HPV, MMTV and EBV, in Australian breast and prostate cancer specimens, suggesting a causal role in initiating carcinogenesis in these tissues. We are now focusing on identifying the mechanisms by which viruses transform cells into cancer cells.

For these projects, we will use basic molecular and cell biology techniques, exosome isolation and transfer, Immunohistochemistry, microarrays, and methyl arrays.

Project 1:  Examining cellular changes induced by viruses

 

Project 2:  Transfer of virus material to neighbouring cells via co-culture and by exosomes

References

  • Chris Hewson, David Capraro, Jon Burdach, Noel Whitaker and Kevin Morris (2016) Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability. Non-coding RNA Research. Xxx. 1-9 (In Press).
  • Lawson JS, Glenn WK, Salyakina D, Clay R, Delprado W, Cheerala B, Tran DD, Ngan CC, Miyauchi S, Karim M, Antonsson A, and Whitaker N J. Human papilloma virus identification in breast cancer patients with previous cervical neoplasia. Front Oncol, 5: 01 Jan 2016. doi.org/10.3389/fonc.2015.00298.
  • James Sutherland Lawson, Wendy K Glenn and Noel James Whitaker. Human Papilloma Viruses and Breast Cancer – Assessment of Causality. Front Oncol, 29, 29 September 2016. Doi.org/10.3389/fonc.2016.00207.

BABS personnel responsible for these projects:

Currently Active: 
Yes