The role of PI(4,5)P2 in lysosomal homeostasis during autophagy

Professor Christina Mitchell
Department of Biochemistry and Molecular Biology, Monash University
18 May 2018 - 3:00pm - 4:00pm
Rountree Room 356, Level 3, Biological Sciences Building D26

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) regulates intracellular ion channel activity, actin cytoskeletal rearrangements, including cilia tip shedding, endocytosis, and other vesicular trafficking events. Recently PI(4,5)P2 has been shown to localise to autolysosomes and play a regulatory role in autophagy, the process by which destruction of damaged proteins or cellular components occurs within the cell in response to starvation or stress. This seminar will further explore the molecular events that regulate PI(4,5)P2 on autolysosomes during autophagy and identify how this may impact on tissue homeostasis and potentially human disease.

Speaker Biography: Professor Christina Mitchell is a physician scientist whose contributions have been in the field of molecular cell biology and intracellular signaling. The major research direction of her group has been the characterization of the metabolic pathways that regulate phosphoinositide signaling. Her group has investigated the functional role of inositol polyphosphate 3- and 4- and 5- phosphatases in various human diseases. She is currently also the Executive Dean of Medicine Nursing and Health Sciences at Monash University.