Dr Paul Waters

Position: 
Senior Lecturer
Room: 
3110, L3 East, Bioscience South E26
Telephone: 
(+612) 9385 1525
Fax: 
(+61 2) 9385 1483

Dr Waters is the BABS Postgraduate Academic Coordinator for 2017
 
Professional Experience
  • 2013-current: Senior Lecturer, School of BABS, UNSW
  • 2009-2012: ARC Fellow, Evolution Ecology & Genetics, Research School of Biology,
    The Australian National University
  • 2007-2009: Research Fellow, Comparative Genomics Group, Research School of Biological Sciences, The Australian National University
  • 2006-2007: Postdoctoral Fellow, ARC Centre for Kangaroo Genomics, Comparative Genomics Group, Research School of Biological Science, The Australian National University
  • 2003-2005: Postdoctoral Fellow, Evolutionary Genomics Group, Department of Zoology, Stellenbosch University, Private Bag X1, Matieland, South Africa

Research Contribution

My research centres on better understanding epigenetic regulation of transcription in diverse vertebrate representatives, specifically focussing on sex chromosomes dosage compensation. The ultimate goal is to understand how complex epigenetic silencing mechanisms evolved. During my PhD I focused on the gene content and evolution of marsupial Y chromosomes, and throughout my first postdoc in South Africa I focused on the genomics of Afrotheria (basal eutherian mammals; which include elephant, aardvarks, etc.).

I was awarded an ARC discovery project to further explore the epigenetics of vertebrate dosage compensation. The next stage of vertebrate genomics and epigenetics for my group involves much use of short read sequencing technologies.

I am currently using the Tasmanian devil to develop a technique for sequencing a whole mammal Y chromosome. For a study of dosage compensation in phylogenetically important vertebrate taxa, I have sequenced the transcriptomes from a male and female elephant, along with a male and female opossum. I use ChIP-Seq to examine the chromatin modifications associated with vertebrate dosage compensation. I have ChIP samples being sequenced from the same opossum cell lines that the transcriptomes were sequenced, which will allow me to directly correlate transcription levels with chromatin modifications on a genome wide scale, avoiding problems associated with variation between individuals and tissue type.

Honours & Awards

  • ARC Fellowship 2009-2014: Origin and Evolution of Mammalian Dosage Compensation
  • May 2007: Invited to present my work on platypus sex chromosomes at the invitation-only US/Australian Joint Workshop on Vertebrate Comparative Genomics
  • November 2008: Invited speaker at the Boden Research Conference, Beyond the Platypus Genome
  • Referee for international journals Heredity, Molecular Biology and Evolution, Genome Biology, PLoS Genetics, BMC Evolutionary Biology, BMC Molecular Biology, Chromosome Research and Mammalian Genome

Active Research Projects

Publications

Click here for Dr Waters's publications list