Vincent Murray

Associate Professor

Research Contribution: Vincent Murray obtained his PhD from the National Institute for Medical Research in London. After post-doctoral fellowships at Princeton University and the Cancer Institute, Melbourne, Australia, in 1990 he was appointed as an academic at the University of NSW, Sydney, Australia.

His lab has concentrated on several areas including:- Next-generation DNA sequencing techniques; the DNA sequence specificity of drugs used as cancer chemotherapeutic agents; the development of more efficient anti-tumour agents based on cisplatin and bleomycin; and the interaction of UV light and ionising radiation with DNA.

His lab has made significant research contributions as shown by publication of over 100 papers in high profile international refereed journals. His H-index is 27.


1) The use of Next-generation DNA sequencing techniques to examine the cellular effects of anti-cancer drugs.

2) The DNA sequence specificity of drugs used as cancer chemotherapeutic agents;

3) The development of more efficient anti-tumour agents based on cisplatin and bleomycin;

4) The interaction of UV light and ionising radiation with DNA;

5) The influence of chromatin structure on the control of gene expression;

 

Professional Experience

  • Cancer Institute, Melbourne 1982-1990
  • Princeton University 1980-1982
1) the DNA sequence specificity of drugs used as cancer chemotherapeutic agents;

2) the development of more efficient anti-tumour agents based on cisplatin;

3) the use of gene chip microarrays to examine the effects of anti-tumours agents on gene expression;

4) the influence of chromatin structure on the control of gene expression;

5) The use of the human papillomavirus promoter to preferentially target gene therapy to cervical cancer cells.

 

My lab has made significant research contributions as shown by publication of over 75 papers in high profile international refereed journals. One of my Nucleic Acids Research articles has been cited over 400 times. In addition, 13 of my papers have been cited more than 30 times. I have published 3 papers in the Journal of Biological Chemistry (impact factor - 5.8) and 8 in Nucleic Acids Research (impact factor - 6.3).

 

Professional Experience

  • Cancer Institute, Melbourne 1982-1990
  • Princeton University 1980-1982
Journal articles
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Nguyen GTH; Leung WY; Tran TN; Wang H; Murray V; Donald WA, 2020, 'Mechanism for the Binding of Netropsin to Hairpin DNA Revealed Using Nanoscale Ion Emitters in Native Mass Spectrometry', Analytical Chemistry, vol. 92, pp. 1130 - 1137, http://dx.doi.org/10.1021/acs.analchem.9b04209
2020
Murray V; Hardie ME; Gautam SD, 2020, 'Comparison of different methods to determine the DNA sequence preference of ionising radiation-induced DNA damage', Genes, vol. 11, http://dx.doi.org/10.3390/genes11010008
2020
Hardie ME; Murray V, 2019, 'The sequence preference of gamma radiation-induced DNA damage as determined by a polymerase stop assay', International Journal of Radiation Biology, vol. 95, pp. 1613 - 1626, http://dx.doi.org/10.1080/09553002.2019.1665216
2019
Hardie ME; Gautam SD; Murray V, 2019, 'The genome-wide sequence preference of ionising radiation-induced cleavage in human DNA', Molecular Biology Reports, vol. 46, pp. 3731 - 3745, http://dx.doi.org/10.1007/s11033-019-04815-6
2019
Murray V; Chen JK; Yang D; Shen B, 2018, 'The genome-wide sequence specificity of DNA cleavage by bleomycin analogues in human cells', Bioorganic and Medicinal Chemistry, vol. 26, pp. 4168 - 4178, http://dx.doi.org/10.1016/j.bmc.2018.07.006
2018
Leung WY; Chung LH; Kava HW; Murray V, 2018, 'RecBCD (Exonuclease V) is inhibited by DNA adducts produced by cisplatin and ultraviolet light', Biochemical and Biophysical Research Communications, vol. 495, pp. 666 - 671, http://dx.doi.org/10.1016/j.bbrc.2017.11.060
2018
Khoe CV; Chung LH; Murray V, 2018, 'The sequence specificity of UV-induced DNA damage in a systematically altered DNA sequence', Journal of Photochemistry and Photobiology B: Biology, vol. 183, pp. 88 - 100, http://dx.doi.org/10.1016/j.jphotobiol.2018.04.023
2018
Johnson BW; Burgess MW; Murray V; Aldrich-Wright JR; Temple MD, 2018, 'The interactions of novel mononuclear platinum-based complexes with DNA', BMC Cancer, vol. 18, pp. 1284, http://dx.doi.org/10.1186/s12885-018-5194-8
2018
Murray V; Chen JK; Chung LH, 2018, 'The interaction of the metallo-glycopeptide anti-tumour drug bleomycin with DNA', International Journal of Molecular Sciences, vol. 19, http://dx.doi.org/10.3390/ijms19051372
2018
Gautam SD; Hardie ME; Murray V, 2018, 'The Sequence Preference of Gamma-Radiation-Induced Damage in End-Labeled DNA after Heat Treatment', Radiation Research, vol. 189, pp. 238 - 250, http://dx.doi.org/10.1667/RR14886.1
2018
Hardie ME; Murray V, 2018, 'The sequence preference of DNA cleavage by T4 endonuclease VII', Biochimie, vol. 146, pp. 1 - 13, http://dx.doi.org/10.1016/j.biochi.2017.11.002
2018
Chung LH; Murray V, 2018, 'An extended sequence specificity for UV-induced DNA damage', Journal of Photochemistry and Photobiology B: Biology, vol. 178, pp. 133 - 142, http://dx.doi.org/10.1016/j.jphotobiol.2017.10.034
2018
Chen JK; Yang D; Shen B; Murray V, 2017, 'Bleomycin analogues preferentially cleave at the transcription start sites of actively transcribed genes in human cells', International Journal of Biochemistry and Cell Biology, vol. 85, pp. 56 - 65, http://dx.doi.org/10.1016/j.biocel.2017.02.001
2017
Gautam SD; Chen JK; Murray V, 2017, 'The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence', Journal of Biological Inorganic Chemistry, vol. 22, pp. 881 - 892, http://dx.doi.org/10.1007/s00775-017-1466-z
2017
Johnson BW; Murray V; Temple MD, 2016, 'Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes', BMC Cancer, vol. 16, http://dx.doi.org/10.1186/s12885-016-2368-0
2016
Chung LH; Murray V, 2016, 'The mitochondrial DNA sequence specificity of the anti-tumour drug bleomycin using end-labeled DNA and capillary electrophoresis and a comparison with genome-wide DNA sequencing', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1008, pp. 87 - 97, http://dx.doi.org/10.1016/j.jchromb.2015.11.029
2016
Murray V; Chen JK; Tanaka MM, 2016, 'The genome-wide DNA sequence specificity of the anti-tumour drug bleomycin in human cells', Molecular Biology Reports, vol. 43, pp. 639 - 651, http://dx.doi.org/10.1007/s11033-016-3998-7
2016
Chen JK; Murray V, 2016, 'The determination of the DNA sequence specificity of bleomycin-induced abasic sites', Journal of Biological Inorganic Chemistry, vol. 21, pp. 395 - 406, http://dx.doi.org/10.1007/s00775-016-1349-8
2016
Chen JK; Yang D; Shen B; Neilan BA; Murray V, 2016, 'Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues', Bioorganic and Medicinal Chemistry, vol. 24, pp. 6094 - 6101, http://dx.doi.org/10.1016/j.bmc.2016.09.072
2016
Kava HW; Murray V, 2016, 'CpG methylation increases the DNA binding of 9-aminoacridine carboxamide Pt analogues', Bioorganic and Medicinal Chemistry, vol. 24, pp. 4701 - 4710, http://dx.doi.org/10.1016/j.bmc.2016.08.011
2016
Hardie ME; Kava HW; Murray V, 2016, 'Cisplatin Analogues with an Increased Interaction with DNA: Prospects for Therapy.', Curr Pharm Des, vol. 22, pp. 6645 - 6664, http://dx.doi.org/10.2174/1381612822666160831101529
2016
Murray V, 2015, 'The frequency of poly(G) tracts in the human genome and their use as a sensor of DNA damage', Computational Biology and Chemistry, vol. 54, pp. 13 - 17, http://dx.doi.org/10.1016/j.compbiolchem.2014.11.006
2015
Murray V; Taylor CB; Gero AM; Lutze-Mann LH, 2015, 'The influence of p53 status on the cytotoxicity of fluorinated pyrimidine L-nucleosides', Chemico-Biological Interactions, vol. 240, pp. 102 - 109, http://dx.doi.org/10.1016/j.cbi.2015.08.010
2015
Murray V; Chen JK; Galea AM, 2014, 'The anti-tumor drug bleomycin preferentially cleaves at the transcription start sites of actively transcribed genes in human cells', Cellular and Molecular Life Sciences, vol. 71, pp. 1505 - 1512, http://dx.doi.org/10.1007/s00018-013-1456-4
2014
Murray V; Chen JK; Galea AM, 2014, 'The potential of acridine carboxamide Pt complexes as anti-cancer agents: A review', Anti-Cancer Agents in Medicinal Chemistry, vol. 14, pp. 695 - 705, http://dx.doi.org/10.2174/18715206113136660361
2014
Kava HW; Galea AM; Md. Jamil F; Feng Y; Murray V, 2014, 'Characterising the atypical 5′-CG DNA sequence specificity of 9-aminoacridine carboxamide Pt complexes', Journal of Biological Inorganic Chemistry, vol. 19, pp. 997 - 1007, http://dx.doi.org/10.1007/s00775-014-1144-3
2014
Murray V; Chen JK; Galea AM, 2014, 'Enhanced DNA repair of bleomycin-induced 3'-phosphoglycolate termini at the transcription start sites of actively transcribed genes in human cells', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 769, pp. 93 - 99, http://dx.doi.org/10.1016/j.mrfmmm.2014.06.006
2014
Nguyen TVT; Chen JK; Murray V, 2013, 'Bleomycin DNA damage: Anomalous mobility of 3'-phosphoglycolate termini in an automated capillary DNA sequencer', Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, vol. 913-914, pp. 113 - 122, http://dx.doi.org/10.1016/j.jchromb.2012.11.029
2013
Nguyen HT; Galea AM; Murray V, 2013, 'The interaction of cisplatin with a human telomeric DNA sequence containing seventeen tandem repeats', Bioorganic and Medicinal Chemistry Letters, vol. 23, pp. 1041 - 1045, http://dx.doi.org/10.1016/j.bmcl.2012.12.021
2013
Nguyen TVT; Murray V, 2013, 'The electrophoretic mobility of DNA fragments differing by a single 3'-terminal nucleotide in an automated capillary DNA sequencer', Biomedical Chromatography, vol. 27, pp. 390 - 395, http://dx.doi.org/10.1002/bmc.2804
2013
Murray V; Kandasamy N, 2012, 'The sequence specificity of the anti-tumour drug, Cisplatin, in telomeric DNA sequences compared with consecutive guanine DNA sequences', Anti-Cancer Agents in Medicinal Chemistry, vol. 12, pp. 177 - 181, http://dx.doi.org/10.2174/187152012800228742
2012
Nguyen H; Murray V, 2012, 'The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells.', Journal of Biological Inorganic Chemistry, vol. 17, pp. 1209 - 1215, http://dx.doi.org/10.1007/s00775-012-0934-8
2012
Murray V; Galea AM, 2012, 'Gene expression profiling of the cancer chemotherapeutic agent, Cisplatin, compared with its ineffective isomer, Transplatin.', Journal of Computer Science and Systems Biology, vol. 5, pp. 37, http://dx.doi.org/10.4172/0974-7230.S1.02
2012
Murray V; Nguyen TVT; Chen JK, 2012, 'The use of automated sequencing techniques to investigate the sequence selectivity of DNA-damaging agents.', Chemical Biology and Drug Design, vol. 80, pp. 1 - 8, http://dx.doi.org/10.1111/j.1747-0285.2012.01379.x
2012
Paul M; Murray V, 2012, 'Use of an automated capillary DNA sequencer to investigate the interaction of cisplatin with telomeric DNA sequences', Biomedical Chromatography, vol. 26, pp. 350 - 354, http://dx.doi.org/10.1002/bmc.1664
2012
Nguyen TVT; Murray V, 2012, 'Human telomeric DNA sequences are a major target for the anti-tumour drug, Bleomycin.', Journal of Biological Inorganic Chemistry, vol. 17, pp. 1 - 9, http://dx.doi.org/10.1007/s00775-011-0818-3
2012
Lung MS; Zhang N; Murray V, 2012, 'Site-directed mutagenesis of human papillomavirus 18 promoter elements and tissue-specific expression in cervical carcinoma cells.', Virus Genes, vol. 44, pp. 395 - 402, http://dx.doi.org/10.1007/s11262-012-0723-z
2012
Murray V; Campbell HM; Gero AM, 2012, 'Plasmodium falciparum: The potential of the cancer chemotherapeutic agent cisplatin and its analogues as anti-malarials.', Experimental Parasitology, vol. 132, pp. 440 - 443, http://dx.doi.org/10.1016/j.exppara.2012.09.004
2012
Nguyen HTQ; Murray V, 2012, 'The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells', Journal of Biological Inorganic Chemistry, pp. 1 - 7, http://dx.doi.org/10.1007/s00775-012-0934-8
2012
Murray V; Campbell HM; Gero AM, 2011, 'Plasmodium falciparum: DNA sequence specificity of cisplatin and cisplatin analogues', Experimental Parasitology, vol. 128, pp. 396 - 400, http://dx.doi.org/10.1016/j.exppara.2011.05.002
2011
Lung ; Lung ; Murray V, 2011, 'The use of a human papillomavirus 18 promoter for tissue specific expression in cervical carcinoma cells.', Cellular and Molecular Biology Letters, vol. 16, pp. 477 - 492, http://dx.doi.org/10.2478/s11658-011-0018-8
2011
Paul M; Murray V, 2011, 'The sequence selectivity of DNA-targeted 9-aminoacridine cisplatin analogues in a telomere-containing DNA sequence.', Journal of Biological Inorganic Chemistry, vol. 16, pp. 735 - 743, http://dx.doi.org/10.1007/s00775-011-0774-y
2011
Murray V, 2010, 'Nucleosomes and Cisplatin.', Chemistry and biology, vol. 17, pp. 1271 - 1272, http://dx.doi.org/10.1016/j.chembiol.2010.12.002
2010
Holmes RJ; Abrahams B; Murray V; Denny WA; David McFadyen W, 2010, 'A 2D hydrogen-bonded network constructed from large organic dications.', Journal of Molecular Structure, vol. 975, pp. 186 - 189, http://dx.doi.org/10.1016/j.molstruc.2010.04.020
2010
Carland M; Grannas MJ; Cairns MJ; Roknic VJ; Denny WA; David McFadyen W; Murray V, 2010, 'Substituted 9-aminoacridine-4-carboxamides tethered to platinum(II)diamine complexes: Chemistry, cytotoxicity and DNA sequence selectivity.', Journal of Inorganic Biochemistry, vol. 104, pp. 815 - 819, http://dx.doi.org/10.1016/j.jinorgbio.2010.03.011
2010
Galea AM; Murray V, 2010, 'The influence of chromatin structure on DNA damage induced by nitrogen mustards and cisplatin analogues.', Chemical Biology and Drug Design, vol. 75, pp. 578 - 589, http://dx.doi.org/10.1111/j.1747-0285.2010.00969.x
2010
Cairns MJ; Carland M; David McFadyen W; Denny WA; Murray VM, 2009, 'The DNA sequence selectivity of maltolato-containing cisplatin analogues in purified plasmid DNA and in intact human cells', Journal of Inorganic Biochemistry, vol. 103, pp. 1151 - 1155, http://dx.doi.org/10.1016/j.jinorgbio.2009.06.001
2009
Galea AM; Murray VM, 2008, 'The anti-tumour agent, Cisplatin, and its clinically ineffective isomer, Transplatin, produce unique gene expression profiles in human cells', Cancer Informatics, vol. 6, pp. 315 - 355
2008
White JM; Mcfadyen WD; Carland M; Denny WA; Murray VM, 2006, '9,9a-diphenyl-1,3,4,6,7,9a-hexahydro-2H-pyrazino[1,2-a]pyrimidine at 130 K', ACTA Crystallographica Section E - Structure Reports Online, vol. 62, pp. O1846 - O1848, http://dx.doi.org/10.1107/S1600536806012463
2006
Carland M; Abrahams B; Rede T; Stephenson J; Murray VM; Denny WA; Mcfadyen WD, 2006, 'Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands', Inorganica Chimica Acta, vol. 359, pp. 3252 - 3256, http://dx.doi.org/10.1016/j.ica.2006.03.008
2006
Temple MD; Murray VM, 2005, 'Footprinting the `essential regulatory region` of the retinoblastoma gene promoter in intact human cells', International Journal of Biochemistry and Cell Biology, vol. 37, pp. 665 - 678, http://dx.doi.org/10.1016/j.biocel.2004.09.005
2005
Carland M; Tan KJ; White JM; Stephenson J; Murray VM; Denny WA; Mcfadyen WD, 2005, 'Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol', Journal of Inorganic Biochemistry, vol. 99, pp. 1738 - 1743, http://dx.doi.org/10.1016/j.jinorgbio.2005.06.003
2005
Carland M; Abrahams B; Denny WA; Murray VM; Mcfadyen WD, 2005, 'Hydrogen-bonded networks from novel platinum(II) dimers', CrystEngComm, vol. 7, pp. 701 - 705, http://dx.doi.org/10.1039/b511536a
2005
Temple MD; Freebody J; Murray VM, 2004, 'Genomic and phylogenetic footprinting at the epsilon-globin silencer region in intact human cells', Biochimica et Biophysica ACTA, vol. 1678, pp. 126 - 134, http://dx.doi.org/10.1016/j.bbaexp.2004.03.003
2004
Davies NP; Freebody J; Murray VM, 2004, 'Chromatin structure at the flanking regions of the human beta-globin locus control region DNase I hypersensitive site-2: proposed nucleosome positioning by DNA-binding proteins including GATA-1', Biochimica et Biophysica ACTA, vol. 1679, pp. 201 - 213, http://dx.doi.org/10.1016/j.bbaexp.2004.04.002
2004
Robillard MS; Davies NP; van der Marel GA; van Boom JH; Reedijk J; Murray VM, 2003, 'The interaction of peptide-tethered platinum(II) complexes with DNA', Journal of Inorganic Biochemistry, vol. 96, pp. 331 - 338, http://dx.doi.org/10.1016/S0162-0134(03)00180-6
2003
Attema JL; Reeves R; Murray V; Levichkin I; Temple MD; Tremethick DJ; Shannon AF, 2002, 'The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation', JOURNAL OF IMMUNOLOGY, vol. 169, pp. 2466 - 2476, http://dx.doi.org/10.4049/jimmunol.169.5.2466
2002
Galea AM; Murray V, 2002, 'The interaction of cisplatin and analogues with DNA in reconstituted chromatin', Biochimica et Biophysica Acta - Gene Structure and Expression, vol. 1579, pp. 142 - 152, http://dx.doi.org/10.1016/S0167-4781(02)00535-3
2002
Temple MD; Mcfadyen WD; Holmes RJ; Denny WA; Murray VM, 2002, 'The interaction of DNA-targeted 9-aminoacridine-4-carboxamide platinum complexes with DNA in intact human cells', Biochim Biophys ACTA, vol. 1574, pp. 223 - 230, http://dx.doi.org/10.1016/S0167-4781(01)00365-7
2002
Galea AM; Murray VM, 2002, 'Cisplatin preferentially targets the linker region of the nucleosome', Biochim Biophys ACTA, vol. 1579, pp. 142 - 152
2002
Murray VM; Tremethick D; Temple MD, 2002, 'The proximal promoter of the human interleukin-2 gene is occupied by a positional nucleosome that becomes remodelled upon T-cell activation', Journal of Immunology, vol. 169, pp. 2466 - 2476
2002
Holmes RJ; Mckeage M; Murray VM; Denny WA; Mcfadyen DW, 2001, 'cis-Dichloroplatinum(II) complexes tethered to 9-aminoacridine-4-carboxamides: synthesis and action in resistant cell lines in vitro', Journal of Inorganic Biochemistry, vol. 85, pp. 209 - 217, http://dx.doi.org/10.1016/S0162-0134(01)00188-X
2001
Kim A; Murray VM, 2001, 'Chromatin structure at the 3`-boundary of the human B-globin locus control region hypersensitive site-2', International Journal of Biochemistry and Cell Biology, vol. 33, pp. 1183 - 1192, http://dx.doi.org/10.1016/S1357-2725(01)00087-5
2001
Whittaker J; McFadyen WD; Baguley BC; Murray V, 2001, 'The interaction of DNA-targeted platinum phenanthridinium complexes with DNA in human cells', Anti-Cancer Drug Design, vol. 16, pp. 81 - 89
2001
Whittaker JK; Mcfadyen DW; Baguley BC; Murray VM, 2001, 'The interaction of DNA-targeted platinum phenanthridinium complexes with DNA in human cells', Anti-Cancer Drug Design, vol. 16, pp. 1 - 9
2001
Davies NP; Hardman LC; Murray VM, 2000, 'The effect of chromatin structure on cisplatin damage in intact human cells', Nucleic Acids Research, vol. 28, pp. 2954 - 2958
2000
Temple MD; Mcfadyen DW; Holmes RJ; Denny WA; Murray VM, 2000, 'Interaction of cisplatin and DNA-targeted 9-aminoacridine platinum complexes with DNA', Biochemistry, vol. 39, pp. 5593 - 5599, http://dx.doi.org/10.1021/bi9922143
2000
Murray VM, 2000, 'A survey of the sequence-specific interaction of damaging agents with DNA: emphasis on antitumor agents', Progress in Nucleic Acid Research and Molecular Biology, vol. 63, pp. 367 - 415
2000
Kim A; Murray VM, 2000, 'A large `footprint` at the boundary of the human beta-globin locus control region hypersensitive site-2', International Journal of Biochemistry and Cell Biology, vol. 32, pp. 695 - 702, http://dx.doi.org/10.1016/S1357-2725(00)00023-6
2000
Davies NP; Murray VM, 2000, 'Shortened protocol for terminal deoxynucleotidyl transferase-dependent PCR', BioTechniques, vol. 29, pp. 1168 - 1172
2000
Temple MD; Cairns MJ; Kim A; Murray VM, 1999, 'Protein-DNA footprinting of the human epsilon-globin promoter in human intact cells using nitrogen mustard analogues and other DNA-damaging agents', Biochimica et Biophysica ACTA - Bioenergetics, vol. 1445, pp. 245 - 256, http://dx.doi.org/10.1016/S0167-4781(99)00057-3
1999
Murray VM; Whittaker JK; Mcfadyen DW, 1998, 'DNA sequence selectivity of cisplatin analogues in intact human cells', Chemico - Biological Interactions, vol. 110, pp. 27 - 37, http://dx.doi.org/10.1016/S0009-2797(97)00110-5
1998
Whittaker JK; Mcfadyen DW; Wickham G; Wakelin L; Murray VM, 1998, 'The interaction of DNA-targeted platinum phenanthridinium complexes with DNA', Nucleic Acids Research, vol. 26, pp. 3933 - 3939
1998
Cairns MJ; Murray VM, 1998, 'Detection of protein-DNA interactions at beta-globin gene cluster in intact human cells utilizing hedamycin as DNA-damaging agent', DNA and Cell Biology, vol. 17, pp. 325 - 333, http://dx.doi.org/10.1089/dna.1998.17.325
1998
Cairns MJ; Murray VM, 1998, 'The DNA sequence specificity of hedamycin damage determined by ligation-mediated PCR and linear amplification', Biochemistry and Molecular Biology International, vol. 46, pp. 267 - 275
1998
Hardman LC; Murray VM, 1997, 'Use of an automated sequencer to determine the sequence specificity of DNA damage', Biochemistry and Molecular Biology International, vol. 42, pp. 349 - 359
1997
Murray VM; Whittaker JK; Temple MD; Mcfadyen DW, 1997, 'Interaction of 11 cisplatin analogues with DNA: characteristic pattern of damage with monofunctional analogues', Biochimica et Biophysica ACTA - Gene Structure and Expression, vol. 1354, pp. 261 - 271, http://dx.doi.org/10.1016/S0167-4781(97)00087-0
1997
Temple MD; Cairns MJ; Denny WA; Murray VM, 1997, 'Protein-DNA interactions in the human beta-globin locus control region hypersensitive site-2 as revealed by four nitrogen mustards', Nucleic Acids Research, vol. 25, pp. 3255 - 3260, http://dx.doi.org/10.1093/nar/25.16.3255
1997
Cairns MJ; Murray V, 1996, 'Influence of chromatin structure on bleomycin-DNA interactions at base pair resolution in the human β-globin gene cluster', Biochemistry, vol. 35, pp. 8753 - 8760, http://dx.doi.org/10.1021/bi9600207
1996
Murray VM; Matias C; Mcfadyen WD; Wickham G, 1996, 'The influence of linker chain length on the sequence specificity of DNA damage by n-bromoalkylphenenthridinium bromides in plasmid DNA and in intact human cells', Biochimica et Biophysica ACTA, vol. 1305, pp. 79 - 86, http://dx.doi.org/10.1016/0167-4781(95)00211-1
1996
Murray V; Moore AG; Matias C; Wickham G, 1995, 'The interaction of hedamycin and DC92-B in a sequence selective manner with DNA in intact human cells', BBA - Gene Structure and Expression, vol. 1261, pp. 195 - 200, http://dx.doi.org/10.1016/0167-4781(94)00236-V
1995
Prakash AS; Moore A; Murray VM; Matias C; Mcfadyen WD; Wickham G, 1995, 'Comparison of the sequence selectivity of the DNA-alkylating pluramycin antitumour antibiotics DC92-B and hedamycin', Chemico - Biological Interactions, vol. 95, pp. 17 - 28, http://dx.doi.org/10.1016/0009-2797(94)03341-2
1995
Murray VM; Moore A; Matias C; Wickham G, 1995, 'The influence of chromatin structure on the sequence specific interaction of hedamycin and DC92-B with DNA in intact human cells', Biochimica et Biophysica ACTA - Bioenergetics, vol. 1261, pp. 195 - 200
1995
Murray V; Martin RF, 1994, 'Ultraviolet light-induced cleavage of DNA in presence of iodoHoechst 33258: The sequence specificity of the reaction', Nucleic Acids Research, vol. 22, pp. 506 - 513, http://dx.doi.org/10.1093/nar/22.3.506
1994
Cairns MJ; Murray V, 1994, 'Comparison of the sequence specificity of cis-diamminedichloroplatinum (II) damage in guanine- and 7-deazaguanine-containing DNA', BBA - Gene Structure and Expression, vol. 1218, pp. 315 - 321, http://dx.doi.org/10.1016/0167-4781(94)90183-X
1994
Cairns MJ; Murray V, 1994, 'Dideoxy genomic sequencing of a single-copy mammalian gene using more than two hundred cycles of linear amplification', BioTechniques, vol. 17, pp. 910 - 913+914
1994
Holliday R; Murray V, 1994, 'Specificity in splicing', BioEssays, vol. 16, pp. 771 - 774, http://dx.doi.org/10.1002/bies.950161013
1994
Murray V; Monchawin C, 1994, 'A polymerase chain reaction on human alphoid DNA produces a characteristic ladder of bands', Biochemistry and Molecular Biology International, vol. 34, pp. 323 - 327
1994
Murray V; Monchawin C; England PR, 1993, 'The determination of the sequences present in the shadow bands of a dinucleotide repeat PCR', Nucleic Acids Research, vol. 21, pp. 2395 - 2398, http://dx.doi.org/10.1093/nar/21.10.2395
1993
Murray V; Monchawin C; Cairns MJ; England PR; Leigh D; McDonald BL, 1993, 'Detection of polymorphisms using thermal cycling with a single oligonucleotide on a DNA sequencing gel', Human Mutation, vol. 2, pp. 118 - 122, http://dx.doi.org/10.1002/humu.1380020210
1993
England PR; Murray V, 1993, 'Sequence-Specific DNA Damage Using Iodine-125-Labeled Antisense Oligonucleotides', Antisense Research and Development, vol. 3, pp. 219 - 224, http://dx.doi.org/10.1089/ard.1993.3.219
1993
Murray V; Motyka H; England PR; Wickham G; Lee HH; Denny WA; McFadyen WD, 1992, 'The use of Taq DNA polymerase to determine the sequence specificity of DNA damage caused by cis-diamminedichloroplatinum(II), acridine-tethered platinum(II) diammine complexes or two analogues', Journal of Biological Chemistry, vol. 267, pp. 18805 - 18809
1992
Murray V; Motyka H; England PR; Wickham G; Lee HH; Denny WA; McFadyen WD, 1992, 'An Investigation of the Sequence-Specific Interaction of Cis-Diamminedichloroplatinum(Ii) and Four Analogs, Including two Acridine-Tethered Complexes with DNA Inside Human Cells', Biochemistry, vol. 31, pp. 11812 - 11817, http://dx.doi.org/10.1021/bi00162a020
1992
Murray V; Monchawin C; England PR; Neilan BA; Leigh D; Mcdonald BL, 1992, 'Direct PCR Sequencing of Dystrophin Polymorphic CACA Alleles after Purification to Remove Shadow Bands', DNA and Cell Biology, vol. 11, pp. 637 - 640, http://dx.doi.org/10.1089/dna.1992.11.637
1992
Murray V, 1990, 'Are transposons a cause of ageing?', Mutation Research DNAging, vol. 237, pp. 59 - 63, http://dx.doi.org/10.1016/0921-8734(90)90011-F
1990
Murray V; Martin RF, 1989, 'The degree of ultraviolet light damage to DNA containing iododeoxyuridine or bromodeoxyuridine is dependent on the DNA sequence', Nucleic Acids Research, vol. 17, pp. 2675 - 2691, http://dx.doi.org/10.1093/nar/17.7.2675
1989
Murray V, 1989, 'Improved double-stranded DNA sequencing using the linear polymerase chain reaction', Nucleic Acids Research, vol. 17, pp. 8889, http://dx.doi.org/10.1093/nar/17.21.8889
1989
Murray V; Tan L; Matthews J; Martin RF, 1988, 'The sequence specificity of bleomycin damage in three cloned DNA sequences that differ by a small number of base substitutions', Journal of Biological Chemistry, vol. 263, pp. 12854 - 12859
1988
Murray V, 1987, 'Transversion-specific purine analogue mutagens and the mechanism of hydroxylaminopurine mutagenesis', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 177, pp. 189 - 199, http://dx.doi.org/10.1016/0027-5107(87)90002-9
1987
Murray V, 1987, 'O6-Methylguanine specifically induces AT→GC transition mutations', Mutation Research Letters, vol. 190, pp. 267 - 270, http://dx.doi.org/10.1016/0165-7992(87)90007-8
1987
Murray V, 1987, '5-Amino-4-imidazolecarboxamide is a mutagen in E. coli', Mutation Research Letters, vol. 190, pp. 89 - 94, http://dx.doi.org/10.1016/0165-7992(87)90037-6
1987
Murray V; Martin RF, 1987, 'Nucleotide sequences of human α-DNA repeats', Gene, vol. 57, pp. 255 - 259, http://dx.doi.org/10.1016/0378-1119(87)90129-6
1987
Murray V; Martin RF, 1985, 'A novel method for the purification of DNA single strands suitable for DNA sequencing', Gene Analysis Techniques, vol. 2, pp. 95 - 99, http://dx.doi.org/10.1016/0735-0651(85)90004-4
1985
Murray V; Martin RF, 1985, 'The sequence specificity of bleomycin-induced DNA damage in intact cells', Journal of Biological Chemistry, vol. 260, pp. 10389 - 10391
1985
Murray V; Holliday R, 1981, 'Increased error frequency of DNA polymerases from senescent human fibroblasts', Journal of Molecular Biology, vol. 146, pp. 55 - 76, http://dx.doi.org/10.1016/0022-2836(81)90366-1
1981
Murray V, 1981, 'Properties of DNA polymerases from young and ageing human fibroblasts', Mechanisms of Ageing and Development, vol. 16, pp. 327 - 343, http://dx.doi.org/10.1016/0047-6374(81)90017-8
1981
Holliday R; Pukkila PJ; Dickson JM; Spanos A; Murray V, 1979, 'Relationships between the correction of mismatched bases in DNA and mutability', Cold Spring Harbor Symposia on Quantitative Biology, vol. 43, pp. 1317 - 1323, http://dx.doi.org/10.1101/sqb.1979.043.01.151
1979
Murray V; Holliday R, 1979, 'Mechanism for RNA splicing of gene transcripts', FEBS Letters, vol. 106, pp. 5 - 7, http://dx.doi.org/10.1016/0014-5793(79)80682-1
1979
Murray V; Holliday R, 1979, 'A mechanism for RNA–RNA splicing and a model for the control of gene expression', Genetical Research, vol. 34, pp. 173 - 188, http://dx.doi.org/10.1017/S0016672300019406
1979
Conference Papers
add
Murray V; Galea AM, 2009, 'The Unique Gene Expression Profile of the Anti-tumour Agent, Cisplatin, Compared with its Clinically Ineffective Isomer, Transplatin.', in Proceedings of the 2nd International Conference on Biomedical and Pharmaceutical Engineering, IEEE, Singapore, presented at 2nd International Conference on Biomedical and Pharmaceutical Engineering, Singapore, 02 December 2009 - 04 December 2009, http://dx.doi.org/10.1109/ICBPE.2009.5384103
2009
Galea AM; Murray VM, 2002, 'Investigating the effect of cisplatin on human gene expression using cDNA microarrays', in Takayama K (ed.), School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, Sydney, presented at School of Biotechnology and Biomolecular Sciences 1st Annual Symposium, Sydney, 08 November 2002
2002
Campbell HM; Katrib M; Murray VM; Gero AM, 2002, 'Potential of DNA damaging agents for antimalarial chemotherapy', in 51st ASTMH Meeting, 51st ASTMH Meeting, Denver, Colorado, presented at 51st ASTMH Meeting, Denver, Colorado, 01 January 2002
2002
Galea AM; Murray VM, 2002, 'The interaction of anti-tumour agents with nucleosomal core DNA in reconstituted chromatin', in ComBio Conference, ComBio Conference, Sydney, presented at ComBio Conference, Sydney, 01 January 2002
2002
Davies NP; Hardman LC; Murray VM, 2002, 'The influence of chromatin structure on cisplatin damage in intact human cells at the epsilon globin gene promoter', in ComBio Conference, ComBio Conference, Sydney, presented at ComBio Conference, Sydney, 01 January 2002
2002
Galea AM; Murray VM, 2002, 'Gene expression profiling of human tumour cells using cDNA microarrays: a model test system for anti-tumour drug development', in 2nd Australian Microarray Meeting, 2nd Australian Microarray Meeting, Sth Stradbroke Island, Australia, presented at 2nd Australian Microarray Meeting, Sth Stradbroke Island, Australia, 01 January 2002
2002
Temple MD; Murray VM, 2001, 'Footprinting of chromatin structure in the human beta globin gene cluster', in ComBio 2001, ComBio 2001, Canberra, pp. 43 - 43, presented at ComBio 2001, Canberra, 01 October 2001 - 04 October 2001
2001
Galea AM; Murray VM, 2001, 'The Interaction of cisplatin with DNA in reconstituted chromatin', in Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, pp. 44 - 44, presented at Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, 17 February 2002 - 21 February 2002
2001
Davies NP; Hardman LC; Murray VM, 2001, 'The influence of chromatin structure on cisplatin damage in intact human cells at the epsilon-globin gene promoter', in Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, pp. 33 - 33, presented at Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, 17 February 2002 - 21 February 2002
2001
Kim A; Davies NP; Murray VM, 2001, 'What is present at the boundary of a DNASE I hypersensitive site? Chromatin structure at the human beta globin locus control region hypersensitive site-2', in Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, pp. 11 - 11, presented at Genome Conference 2001: 22nd Annual Conference on the Organisation and Expression of the Genome, Lorne, Victoria, 17 February 2002 - 21 February 2002
2001
Kim A; Murray VM, 1999, 'Chromatin structure in locus control region hypersensitive site-2 of human beta -globin gene cluster', in World Congress of Korean Scientists and Engineers 1999, World Congress of Korean Scientists and Engineers 1999, Seoul, South Korea, presented at World Congress of Korean Scientists and Engineers 1999, Seoul, South Korea, 06 July 1999 - 16 July 1999
1999

The development of more effective anti-cancer drugs based on cisplatin and bleomycin.

The sequence specificity of DNA damaging agents.